G-Quartet hydrogels for effective cell growth applications

Abstract

Functional G-quartet hydrogels formed from natural guanosine cross linked with benzene-1,4-diboronic acid and Mg support cell growth with no visible signs of gel degradation.

Light induced modulation of charge transport phenomena across the bistability region in [Fe(Htrz)2(trz)](BF4) spin crossover micro-rods

“…1 µm length and ca. 200 nm width were obtained as previously reported 8 . It is worth to note that we did not use any surfactant for the synthesis of the particles in order to have access directly to the electrical properties of the pure SCO material.…”

“…[3][4][5] Investigating the electrical properties of spin crossover molecular materials is of outmost importance for the further development of these systems as bistable molecular micro/nanoelectronic devices. Indeed, since the first reports on the spin-state dependence of the dielectric permittivity 6 and DC electrical conductivity 7,8 of SCO compounds the interest in both theoretical and experimental studies of their electrical properties significantly increased [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][27][28][29] Since the optical properties (absorption and refractive index) are also strongly modified upon the spin transition one can anticipate also very interesting photocurrent phenomena in these materials. Here we report the observation of a photo-activated process in micrometric rods of [Fe(Htrz) 2 (trz)](BF 4 ) through the hysteresis region of the thermal spin transition.…”

Commercially Relevant Orthogonal Multi‐Component Supramolecular Hydrogels for Programmed Cell Growth

“…[13] Others have also made use of guanosine-derived gels for cell culture. [14] Surprisingly,g iven their biological importance,t here are very few exampleso fs ugar-basedL MWGs being used for tissue culture. Therea re limited examples of peptides modified with sugars, [15] and BarthØlØmy's nucleobase gelators contain sugar units, [12,13] buto ther sugar-containing gelators appliedint issue engineeringr emainvery rare.…”

Drawing with Iron on a Gel Containing a Supramolecular Siderophore

“…[6] Theb asis for these gels is usually the G 4 ·K + quartet (Figure 1), aH -bonded macrocycle templated by K + that stacks to give nanofibers.G uanosine hydrogels,d escribed ac entury ago, [7] are finding many new and diverse applications in just the past few years. [8][9][10][11][12][13] Since it is not involved in the G-quartet, the nucleosidessugar can be modified to give gels with unique properties.R eaction of the 2',3'-diol with boron species gives functional guanosine-borate gels. [9][10][11][12][13][14] The 5'-OH provides another modification site.L ehn used a5 'hydrazide that reacts with aldehydes to give responsive gels, [15] and we made a5 '-hydrazine that forms G 4 -gels for covalent trapping of toxic a,b-unsaturated carbonyls and remediation of anionic dyes from water.…”

“…[8][9][10][11][12][13] Since it is not involved in the G-quartet, the nucleosidessugar can be modified to give gels with unique properties.R eaction of the 2',3'-diol with boron species gives functional guanosine-borate gels. [9][10][11][12][13][14] The 5'-OH provides another modification site.L ehn used a5 'hydrazide that reacts with aldehydes to give responsive gels, [15] and we made a5 '-hydrazine that forms G 4 -gels for covalent trapping of toxic a,b-unsaturated carbonyls and remediation of anionic dyes from water. [16] To create ap H-switchable hydrogel for "water-in-water" separation of cationic dyes and metal ions,w ee valuated guanosine-5'-carboxylic acid (2)asagelator.Carboxylic acids are pH-responsive groups in many supramolecular gels.…”