G<scp>enetic</scp> F<scp>actors in</scp> E<scp>xternal</scp> A<scp>pical</scp> R<scp>oot</scp> R<scp>esorption and</scp> O<scp>rthodontic</scp> T<scp>reatment</scp>

Hartsfield, James K.; Everett, Eric T.; Al-Qawasmi, Riyad

doi:10.1177/154411130401500205

Cited by 159 publications

(119 citation statements)

References 84 publications

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“…Histological evaluation shows microscopic areas of resorption lacunae on affected root surfaces often leading to permanent loss of tooth structure and shortening of root apex. 1,2 Its prevalence is up to 100% in histologically examined teeth and much lower in teeth examined by routine twodimensional radiographs. 3,4 EARR following orthodontic treatment can be caused by patient-related factors like age, sex, systemic conditions, type of malocclusion and treatment-related factors like appliance type, treatment duration, magnitude of orthodontic force and type of orthodontic tooth movement.…”

Section: Introductionmentioning

confidence: 99%

A radiographic study of external apical root resorption in patients treated with single-phase fixed orthodontic therapy

Agarwal

Chopra

Kumar

et al. 2016

Medical Journal Armed Forces India

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m e d i c a l j o u r n a l a r m e d f o r c e s i n d i a 7 2 ( 2 0 1 6 ) s 8 -s 1who had undergone treatment with a single phase of fixed orthodontic therapy were randomly selected from institutional archives. The root apices were evaluated for EARR by a single operator on an radiograph viewing box at a standardized source of light using a four-grade ordinal scale. Anterior EARR was measured on the maxillary and mandibular canines. Posterior EARR was measured on premolars, mesiobuccal and distobuccal roots of maxillary first molars and mesial and distal roots of mandibular first molars. The results were compiled and subjected to statistical analysis. Results:The cases in which the patients underwent therapeutic extraction had a relatively higher amount of EARR compared to the cases in which the patients were treated by nonextraction therapy (P < 0.001). Odds ratio indicated that extraction cases had two-fold increased risk of EARR than non-extraction cases (P < 0.001). No statistically significant difference was observed in the distribution of EARR based on gender or duration of orthodontic treatment (P > 0.05).

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Section: Introductionmentioning

confidence: 99%

A radiographic study of external apical root resorption in patients treated with single-phase fixed orthodontic therapy

Agarwal

Chopra

Kumar

et al. 2016

Medical Journal Armed Forces India

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“…However, this balance may be perturbed by changes in the environment due to pathogens, trauma, orthodontic loading or occlusal interferences (Hartsfield JK Jr, 2004). The literature on root resorption is particularly ambiguous because of controversial and contradictory findings (Krishnan, 2005).…”

Section: Introductionmentioning

confidence: 99%

Orthodontic mechanotransduction and the role of the P2X7 receptor

Viecilli

Katona

Chen

et al. 2009

American Journal of Orthodontics and Dentofacial Orthopedics

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DEDICATIONTo my parents, who have supported my education. iv ACKNOWLEDGMENTSOne of the most important things I have learned during my PhD is the necessity of the existence of a working network of people that can help you achieve your goals. The more effectively this network functions, the higher the chance you will achieve the goals quickly.I would first like to thank my parents, who have unconditionally supported my decision to abandon a profitable private practice in Orthodontics, and return to humble student conditions while aiming for a full time academic career.I also thank my girlfriend Laura Kruter who has (almost always) been ok with my, some might say, not very sane ideas. Sometimes they do turn out fine, though (like this "PhD" one).I can hardly think of anyone else that could have complemented my work and ideas during this Program as well as Dr. Thomas Katona. While I was passionately conditioned to an idea, he was always rational and careful. While I was sometimes furious with a shortcoming, he was always temperate and humorous. When I ran into his office with some news about a project, he would always listen and almost never seem too busy to see me. While I was working and something went wrong, he would listen and wonder with me about the "whys" and "hows", instead of telling me what to do or express disappointment. He was even subject to some of my home culinary experiments. I was extremely fortunate to find someone that thought about science the same way I did, and that actually helped me with my project instead of just telling me what to do. I felt like we worked as a team, and that helped to increase my motivation during my studies. The third part of this project tested the role of the P2X7 receptor in the dentoalveolar morphology of C57B/6 mice. P2X7R KO (knockout) mice were compared to C57B/6 WT to identify differences in a maxillary molar and bone. Tooth dimensions viii were measured and 3D bone morphometry was conducted. No statistically significant differences were found between the two mouse types. P2X7R does not have a major effect on alveolar bone or tooth morphology.The final part examines the role of the P2X7 receptor in a controlled biomechanical model. Orthodontic mechanotransduction was compared in wild-type (WT) and P2X7R knock-out (KO) mice. Using Finite Element Analysis, mouse mechanics were scaled to produce typical human stress levels. Relationships between the biological responses and the calculated stresses were statistically tested and compared.There were direct relationships between certain stress magnitudes and root resorption and bone formation. Hyalinization and root and bone resorption were different in WT and KO. Orthodontic responses are related to the principal stress patterns in the PDL and the P2X7 receptor plays a significant role in their mechanotransduction.

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“…Genetic factors, in part mediated through polymorphisms in the gene for interleukin 1-beta, may predispose certain patients to an increased risk of orthodontically-induced tooth resorption 22 .The inflammatory cytokines interleukin-1 and tumor necrosis factor alpha appear to be involved in the initiation and progression of external root resorption 23 . These cytokines are upregulated in response to periodontal inflammation, periapical pathology and mechanical stress.…”

Section: Discussionmentioning

confidence: 99%