G-TwYST harmonisation of statistical methods for use of omics data in food safety assessment

Equivalence Testing Approaches in Genetically Modified Organism Risk Assessment

“…With regard to the difficulty to obtain sufficient reference data in any single study, the use of databases was proposed in several publications. , However, it should be evaluated if these databases are sufficiently representing the design of the experiments and allow for distinguishing genotypic from environmental variation. With regard to the multiplicity problem, it is currently being discussed whether univariate or multivariate methods are most suitable − and whether the false discovery rate (FDR) is apt or inapt to control false non-discoveries. , It may be time to compare and evaluate the different proposals and improve the science-based methodology if appropriate and where possible, ensuring an open and constructive discussion involving all stakeholders.…”