G07
Bay 78‐1887, a novel lanthanum‐based phosphate binder, decreases intestinal phosphorus absorption in cats

Treatment Options for Hyperphosphatemia in Feline CKD: What's Out there?

“…Food intake did not change during treatment. 61 In another study, four groups of nine normal European shorthair cats were fed a wet veterinary renal diet with lanthanum carbonate octahydrate added at 0, 1.5, 4.5 or 7.5 g/kg of complete food. Similar to the normal cats receiving maintenance food and lanthanum treatment described in the previous study, veterinary food intake was not changed among treatment groups, apparent phosphorus digestibility decreased, intestinal phosphorus absorption was decreased due to increased fecal phosphorus excretion and urinary phosphorus excretion was decreased.…”

Die chronische Niereninsuffizienz – Wie sieht ein effektives Management aus?

“…Bei einem neuen Präparat mit Lanthankarbonat-Octahydrat als phosphatbindendem Wirkstoff konnten in ersten Studien keine Nebenwirkungen bei Katzen festgestellt werden [24,25,28]. Der Wirkstoff Lanthankarbonat ist in der Humanmedizin bereits seit einiger Zeit erfolgreich im Einsatz [12].…”

“…Lanthankarbonat bewirkt bereits in der geringsten empfohlenen Dosis eine deutliche Abnahme der Phosphataufnahme. Die Ausscheidung von Phosphaten mit dem Kot und die Abnahme der Exkretion über die Nieren stehen in direkter Korrelation zur Dosis des Präparats [24,25,28].…”

Oral administration of lanthanum dioxycarbonate does not alter bone morphology of normal cats

“…Lanthanum dioxycarbonate administration was associated with increased PTH and phosphorous concentrations (Table 1). Phosphorus concentrations decreased significantly in control animals (P < 0.005), but not in cats receiving LDOC suggesting that normal cats were able to compensate for low dietary phosphorus concentrations (Schmidt et al, 2006). Phosphorus concentrations tended to decline during the study in all females and in some males.…”