2024
DOI: 10.1091/mbc.e24-02-0062
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G3BP isoforms differentially affect stress granule assembly and gene expression during cellular stress

José M. Liboy-Lugo,
Carla A. Espinoza,
Jessica Sheu-Gruttadauria
et al.

Abstract: Stress granules (SGs) are macromolecular assemblies that form under cellular stress. Formation of these membrane-less organelles is driven by the condensation of RNA and RNA-binding proteins such as G3BPs. G3BPs form SGs following stress-induced translational arrest. Three G3BP paralogs (G3BP1, G3BP2A, and G3BP2B) have been identified in vertebrates. However, the contribution of different G3BP paralogs to stress granule formation and gene expression changes is incompletely understood. Here, we probed the funct… Show more

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