G5 PAMAM dendrimer versus liposome: A comparison study on the in vitro transepithelial transport and in vivo oral absorption of simvastatin

Alpha‐Tocopheryl Succinate‐Conjugated G5 PAMAM Dendrimer Enables Effective Inhibition of Ulcerative Colitis

“…Our previous work showed that the aqueous solubility of α‐TOS, a hydrophobic drug, could be significantly improved by conjugating it with G5‐NH 2 dendrimer, and the resultant conjugate could be completely dissolved in different aqueous solution and was stable under different pH conditions . In addition, as a drug delivery carrier, G5‐NH 2 dendrimer itself shows unique advantages in improving transepithelial transport of the loaded drug . As a result of the greater water solubility and cellular uptake, twice as much anticancer efficacy was achieved by the conjugate than the free α‐TOS .…”

G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol

“…CDDS composed of dendrimers and liposomes not only increases encapsulation efficacy of the loaded drugs, but also modifies their release rates [12,13]. Our previous work demonstrates that PAMAM dendrimer modified nanoliposomes could significantly increase absorption, bioavailability [14] and pharmacodynamic effects [15] of the hydrophobic drugs. However, the limited drug loading capacity of liposomes (usually less than 10%) makes liposome formulation inconvenient to administrate to the patients, especially for those drugs with high therapeutic doses, such as PB with its clinical dosage being 500 mg·d −1 .…”

Preparation and evaluation of chitosan-based nanogels/gels for oral delivery of myricetin

“…However, the poor solubility or instability of many drug candidates in the gastrointestinal (GI) fluid decreases the gastric residence time and consequently lead to the low bioavailability after oral administration (Karnoosh-Yamchi et al, 2014;Qi et al, 2015;Senanayake et al, 2013).…”