G501C polymorphism of the oxidized LDL receptor gene is associated with albuminuria in Chinese essential hypertension patients

Abstract

ABSTRACT. Albuminuria is an independent predictor of renal and cardiovascular complications in hypertensive subjects. We previously showed that lectin-like oxidized low-density lipoprotein receptor 1 (OLR-1) polymorphisms at G501C are associated with susceptibility to essential hypertension and serum C-reactive protein levels. We have now investigated a possible association between OLR-1 polymorphisms at G501C, genotyped by PCR-RFLP, and severity of albuminuria in 307 hypertensive Chinese subjects and 225 age-and gender-matched controls. Urine albumin concentration/urine creatinine concentrations (ACR) were measured to evaluate the severity of albuminuria. Hypertensive subjects had a significantly higher frequency of the CC genotype and the C allele of the OLR-1 polymorphism than controls; this was also true for hypertensive subjects with macroalbuminuria and microalbuminuria OLR-1 polymorphism at G501C in essential hypertension patients compared to those with normoalbuminuria. The mean ACR levels and mean serum C-reactive protein levels in CC carriers were significantly higher than in GG and GC carriers. There was a significant, positive correlation between serum hs-C-reactive protein levels and ACR levels. We conclude that OLR-1 polymorphisms at G501C affect the severity of albuminuria in essential hypertension patients.

OPN Gene Polymorphism and the Serum OPN Levels Confer the Susceptibility and Prognosis of Ischemic Stroke in Chinese Patients

“…Many environmental factors, including age, obesity, hypertension, inflammation, smoking, diabetes mellitus (DM) and lipid disorders, have been established as risk factors for IS. In addition, previous studies also suggest that genetic background can determine the predisposition to IS [4,5,6,7,8,9,10]. …”

HIF1α Genetic Variants and Protein Expressions Determine the Response to Platinum Based Chemotherapy and Clinical Outcome in Patients with Advanced NSCLC

“…Clinically, hypoxia is associated with resistance to anti-tumor treatments, especially radiation therapy, and is predictive of metastasis and poor outcome in a variety of tumor types [10,11,12,13,14,15]. Hypoxia-inducible factor-1α (HIF-1α) is a key factor which regulates cellular response to hypoxia and its important role in the regulation of tumor biological behaviors by affecting angiogenesis, energy metabolism, vasomotor function and apoptotic/proliferative activity has been documented previously [16,17,18].…”

The Gene Polymorphism of LOX1 Predicts the Incidence of LVH in Patients with Essential Hypertension

“…Increasing evidence has indicated the critical roles of systematic vascular inflammation in the occurrence and progression of hypertension and atherosclerosis [27,31,32,33]. Polymorphisms of the OLR1 gene have been reported in association with EH, myocardial infarction (AMI) and coronary artery disease (CAD) [28,30,34]. Hou et al has previously reported that the OLR-1 polymorphism, 501 G>C, was related to the severity of albuminuria among the EH patients [28].…”

“…Polymorphisms of the OLR1 gene have been reported in association with EH, myocardial infarction (AMI) and coronary artery disease (CAD) [28,30,34]. Hou et al has previously reported that the OLR-1 polymorphism, 501 G>C, was related to the severity of albuminuria among the EH patients [28]. The LOX1 501 G>C SNP is located in the open reading frame of the LOX1 gene, resulting in a mis-sense mutation of Lys to Asn at the amino acid position 167 (K167N) [29].…”

“…Hou et al reported that the LOX1 polymorphism is closely related to the serum CRP levels and the occurrence of albuminuria in Chinese hypertensive patients [28,29], suggesting the potential application of the LOX1 polymorphism as a molecular marker for hypertension-related complications. However, the association between the LOX1 polymorphisms and LVH in hypertensive subjects has not yet been reported.…”