2013
DOI: 10.1182/blood.v122.21.1695.1695
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G6PD Deficiency In An HIV Clinic Setting In The Dominican Republic

Abstract: G6PD deficiency is the most common human enzymopathy, particularly in individuals of African descent. Its epidemiology has not been studied in the Dominican Republic, where many individuals have African ancestry. HIV-infected patients are at risk for adverse effects from G6PD deficiency due to receiving prophylaxis with oxidative drugs, which can induce hemolysis in G6PD-deficient patients. We determined the prevalence of G6PD deficiency, as well as the spectrum of variants, in HIV-infected patients at the Clí… Show more

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Cited by 6 publications
(7 citation statements)
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“…found in tropical Africa, the Middle East, tropical and sub-tropical Asia, some parts of the In this study, among the participants with G6PD deficiency, we found 19.2% to harbor the G6PD Aallele (G202/A376) which is associated with reduced enzyme activity [15]. A study by Xu et al in the Dominican Republic also reported a similarly high prevalence of the G6PD A-variant among HIVinfected patients [33]. Of note, we also observed that, among those with G6PD deficiency based on the methemoglobin reductase technique, 30.8% presented with no band on electrophoresis.…”
Section: Discussionsupporting
confidence: 51%
“…found in tropical Africa, the Middle East, tropical and sub-tropical Asia, some parts of the In this study, among the participants with G6PD deficiency, we found 19.2% to harbor the G6PD Aallele (G202/A376) which is associated with reduced enzyme activity [15]. A study by Xu et al in the Dominican Republic also reported a similarly high prevalence of the G6PD A-variant among HIVinfected patients [33]. Of note, we also observed that, among those with G6PD deficiency based on the methemoglobin reductase technique, 30.8% presented with no band on electrophoresis.…”
Section: Discussionsupporting
confidence: 51%
“…In this study, among the participants with G6PD deficiency, we found 19.2% to harbor the G6PD A-allele (G202/ A376), which is associated with the reduced enzyme activity [15]. A study by Xu et al in the Dominican Republic also reported a similarly high prevalence of the G6PD A-variant among HIV-infected patients [36]. Of note, we also observed that, among those with G6PD deficiency based on the methemoglobin reductase technique, 30.8% presented with no band on electrophoresis.…”
Section: Discussionsupporting
confidence: 49%
“…For instance, in a recent case report, hemolysis was the main presentation of acute HIV infection in a 22-year-old patient with G6PD-deficiency (64), although the presence or absence of pain in this case was not reported. It is to be noted that the prevalence of G6PD deficiency in HIV-positive individuals is estimated to be 6.8%-13% (65,66). HIV also confers a 15-40 fold higher risk of acquired thrombotic microangiopathy (45)(46)(47), which is an important cause of hemolysis.…”
Section: Discussionmentioning
confidence: 99%