2021
DOI: 10.3389/fonc.2021.648706
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G6PD-NF-κB-HGF Signal in Gastric Cancer-Associated Mesenchymal Stem Cells Promotes the Proliferation and Metastasis of Gastric Cancer Cells by Upregulating the Expression of HK2

Abstract: Background: Tumor-associated stromal cells have been widely recognized for their tumor-promoting capability involving paracrine signaling. However, the underlying mechanism and the effects of the molecules in the glycolysis pathway in gastric cancer-associated mesenchymal stem cells (GCMSCs) and gastric cancer cells on tumor progression remain unclear.Methods: The expression of hepatocyte growth factor (HGF) in GCMSCs and bone marrow mesenchymal stem cells (BMMSCs) was detected by enzyme-linked immunosorbent a… Show more

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Cited by 20 publications
(18 citation statements)
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“…For instance, MSCs derived from lung cancer facilitate invasion of lung cancer cells probably through inducing epithelial–mesenchymal transition (EMT) and increasing stemness-like properties in lung cancer cells ( 13 ). Meanwhile, gastric cancer-associated MSCs secrete hepatocyte growth factors to promote gastric cancer proliferation and metastasis via c-Myc-hexokinase 2 signaling ( 14 ). Besides, several studies confirm that ovarian cancer-associated MSCs enhance chemoresistance in ovarian cancer in multiple ways, including platelet-derived growth factor signaling, bone morphogenetic protein 4/hedgehog signaling loop, and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway ( 15 17 ).…”
Section: Introductionmentioning
confidence: 99%
“…For instance, MSCs derived from lung cancer facilitate invasion of lung cancer cells probably through inducing epithelial–mesenchymal transition (EMT) and increasing stemness-like properties in lung cancer cells ( 13 ). Meanwhile, gastric cancer-associated MSCs secrete hepatocyte growth factors to promote gastric cancer proliferation and metastasis via c-Myc-hexokinase 2 signaling ( 14 ). Besides, several studies confirm that ovarian cancer-associated MSCs enhance chemoresistance in ovarian cancer in multiple ways, including platelet-derived growth factor signaling, bone morphogenetic protein 4/hedgehog signaling loop, and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway ( 15 17 ).…”
Section: Introductionmentioning
confidence: 99%
“…G6PD is a key enzyme in glucose metabolism and plays an important role in the modulation of proinflammatory responses and oxidative stress in macrophages ( Ham et al, 2013 ). The upregulation of G6PD in gastric cancer activates NF-κB signaling to promote cancer cell metastasis ( Chen et al, 2021 ). CDK1 belongs to cyclin-dependent kinase family and participates in regulating the G2/M phase transition during the cell cycle ( Malumbres, 2014 ).…”
Section: Discussionmentioning
confidence: 99%
“…Conversely, the expression of G6PD and 6PGD was upregulated as the incubation time increased, indicating the effect of other niche factors, instead of hypoxia, inherent in the spheroids on the modulation of cellular metabolism. As an enhancement of the pentose phosphate pathway is reportedly associated with MSC survival and paracrine functionality [25,45], we speculated that metabolic reconfiguration upon spheroid assembly could be an important niche factor contributing to the enhanced therapeutic potential of MSCs.…”
Section: Discussionmentioning
confidence: 99%