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doi:10.6002/ect.tondtdtd2016.p34

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…Lymphopenia is a described characteristic in smokers and is linked to worst health prognoses (Biondini et al, 2019). Therefore, smoking may generate immunosuppressive effects, with a reduction in the number of lymphocytes (Düvenci Birben et al, 2016;Tulgar et al, 2016), and consequently a reduction in the anti-SARS-CoV-2 immune response. In our cohort, COPD and SMOKERS presented increased levels of urea in relation to NC and EX-SMOKERS (Figure 1E).…”

Section: Resultsmentioning

confidence: 99%

COVID-19 Disease Course in Former Smokers, Smokers and COPD Patients

et al. 2021

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The severe respiratory and systemic disease named coronavirus disease-2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, the COVID-19 pandemic presents a huge social and health challenge worldwide. Many different risk factors are associated with disease severity, such as systemic arterial hypertension, diabetes mellitus, obesity, older age, and other co-infections. Other respiratory diseases such as chronic obstructive pulmonary disease (COPD) and smoking are common comorbidities worldwide. Previous investigations have identified among COVID-19 patients smokers and COPD patients, but recent investigations have questioned the higher risk among these populations. Nevertheless, previous reports failed to isolate smokers and COPD patients without other comorbidities. We performed a longitudinal evaluation of the disease course of smokers, former smokers, and COPD patients with COVID-19 without other comorbidities, from hospitalization to hospital discharge. Although no difference between groups was observed during hospital admission, smokers and COPD patients presented an increase in COVID-19-associated inflammatory markers during the disease course in comparison to non-smokers and former smokers. Our results demonstrated that smoking and COPD are risk factors for severe COVID-19 with possible implications for the ongoing pandemic.

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Section: Resultsmentioning

confidence: 99%

COVID-19 Disease Course in Former Smokers, Smokers and COPD Patients

et al. 2021

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“…Exposure to tobacco smoke is a risk factor for various bacterial and viral infections [47,48]. A smoking habit can have a significant negative impact of peripheral blood lymphocyte subsets and their function [49,50]. treatments and a 52% reduction in gastrointestinal treatments [52].…”

Section: Increased Immune Activitymentioning

confidence: 99%

The Potential Health Benefits of Noni Juice: A Review of Human Intervention Studies

West¹,

Deng²,

Isami³

et al. 2018

Preprint

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Noni juice is a globally popular health beverage that originates from the tropics. Traditional Tahitian healers believe the noni plant to be useful for a wide range of maladies, and noni juice consumers throughout the world have similar perceptions. Nevertheless, human clinical trials are necessary for an understanding of what the health benefits of noni juice truly are. A review of published human intervention studies suggest that noni juice may provide protection against tobacco smoke-induced DNA damage, blood lipid and homocysteine elevation, and systemic inflammation. Human interventions studies also suggest that noni juice may improve joint health, increase physical endurance, increase immune activity, inhibit glycation of proteins, aid weight management, help maintain bone health in women, help maintain normal blood pressure, and improve gum health. Further, these studies point to noni juice possessing notable antioxidant activity, more so than the other fruit juices that served as placebos. It is this antioxidant effect, and its interaction with the immune system and inflammation pathways, that may account for many of the observed health benefits of noni juice. However, the existing evidence does have some limitations in its application to noni juice products in general as all the peer-reviewed human interventions studies to-date have involved only one source of French Polynesian noni juice. Geographical factors and variations in processing methods are known to produce commercial noni juice products with divergent phytochemical and nutrient compositions. Therefore, other sources of noni products may have different toxicological and pharmacological profiles.

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The Potential Health Benefits of Noni Juice: A Review of Human Intervention Studies

West

Deng

Isami³

et al. 2018

Foods

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Noni juice is a globally popular health beverage originating in the tropics. Traditional Tahitian healers believe the noni plant to be useful for a wide range of maladies, and noni juice consumers throughout the world have similar perceptions. Nevertheless, human clinical trials are necessary for a precise understanding of what the health benefits of noni juice are. A review of published human intervention studies suggests that noni juice may provide protection against tobacco smoke-induced DNA damage, blood lipid and homocysteine elevation as well as systemic inflammation. Human intervention studies also indicate that noni juice may improve joint health, increase physical endurance, increase immune activity, inhibit glycation of proteins, aid weight management, help maintain bone health in women, help maintain normal blood pressure, and improve gum health. Further, these studies point to notable antioxidant activity in noni juice, more so than other fruit juices which served as trial placebos. It is this antioxidant effect and its interaction with the immune system and inflammation pathways that may account for many of the observed health benefits of noni juice. However, the existing evidence does have some limitations as far as its general application to noni juice products; all the peer-reviewed human interventions studies to date have involved only one source of French Polynesian noni juice. Geographical factors and variations in processing methods are known to produce commercial noni juice products with divergent phytochemical and nutrient compositions. Therefore, other sources of noni products may have different toxicological and pharmacological profiles.

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Untitled

Cited by 3 publications

References 7 publications

COVID-19 Disease Course in Former Smokers, Smokers and COPD Patients

COVID-19 Disease Course in Former Smokers, Smokers and COPD Patients

The Potential Health Benefits of Noni Juice: A Review of Human Intervention Studies

The Potential Health Benefits of Noni Juice: A Review of Human Intervention Studies

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