Ga-68 DOTA-peptides and F-18 FDG PET/CT in patients with neuroendocrine tumor: A review

Evangelista, Laura; Ravelli, Ilaria; Bignotto, Antonio; Cecchin, Diego; Zucchetta, Pietro

doi:10.1016/j.clinimag.2020.05.035

Cited by 40 publications

(29 citation statements)

References 24 publications

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“…This peptide, a DOTA derivatized somatostatin analog, shows high affinity to the SSTR2 subtype of somatostatin receptor expressing tumors and binds the trivalent Ga 3+ with a high kinetic and thermodynamic stability. It is widely used in clinical routines for PET imaging of neuroendocrine tumors 37 . The procedure used to label, purify and determine the radiochemical purity of [ 68 Ga]Ga-DOTA-TOC was essentially the same as that used by our group 33 with some adjustments.…”

mentioning

confidence: 99%

Development and long-term evaluation of a new 68Ge/68Ga generator based on nano-SnO2 for PET imaging

Romero¹,

Martínez²,

Oteo³

et al. 2020

Sci Rep

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Radionuclide generator systems can routinely provide radionuclides on demand such as 68 Ga produced by a 68 Ge/ 68 Ga generator without the availability of an on-site accelerator or a research reactor. thus, in this work nano-Sno 2 was used to develop a new 68 Ge/ 68 Ga generator which was evaluated over a period of 17 months and 305 elution cycles. The elution yield was 91.1 ± 1.8% in the first 7 mL (1 M HCl as eluent) when the generator was new and then it decreased with time and use to 73.8 ± 1.9%. Around 80% of the elutable 68 Ga activity was obtained in 1 mL and the 68 Ge content in the eluate did not exceed 1 × 10-4 % over the investigation period when it was eluted regularly. The described generator provided adequate results for radiolabelling of DotA-toc with direct use of eluate. in addition, [ 68 Ga] Ga-DotA-toc was tested satisfactorily for in vivo tumor detection by micropet/ct imaging in a lung cancer mouse model.

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mentioning

confidence: 99%

Development and long-term evaluation of a new 68Ge/68Ga generator based on nano-SnO2 for PET imaging

Romero¹,

Martínez²,

Oteo³

et al. 2020

Sci Rep

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“…Additionally, there was greater uptake of 68Ga-DOTA-PEPTIDE than 18F-FDG in low-grade NET (median SUV 29 vs 2.9, p < .001) and higher uptake of 18F-FDG over 68Ga-DOTAPEPTIDE in high-grade NET (median SUV 11.7 vs 4.4, p = .03). As a result, a significant correlation was achieved with predominant uptake of 68Ga-DOTAPEPTIDE or 18F-FDG and tumor grade on histology ( p < .0001), with the combination demonstrating the potential for a better comprehensive assessment in intermediate and high-grade tumors (Evangelista et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…Tumors defined as well-differentiated present a greater affinity for somatostatin, allowing the use of radiolabeled somatostatin analogs for imaging of these tumors (Breeman et al 2005 ; Caplin et al 1998 ; Ezziddin et al 2006 ). Although Gallium 68 dotatate positron emission tomography—computed tomography (68Ga-DOTA PETCT) is superior to 18 F-fluorodeoxyglucose ( 18 FDG) PETCT for imaging well-differentiated NET, functional imaging with both 68Ga-DOTA and 18 FDG PETCT has the potential for a more comprehensive tumor assessment in intermediate and high-grade tumors (Evangelista et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

18F-FDG PETCT and 68Ga-DOTA PETCT mismatch with in vivo histopathological characterization of low-grade neuroendocrine pancreatic tumor

Queiroz

Lopes²,

Salgues³

et al. 2021

European J Hybrid Imaging

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Background Pancreatic neuroendocrine tumor (PNET) is a subgroup of neuroendocrine tumor (NET) that has unique biology and natural history. The histological classification has a major role in the management of this pathology, but in recent years Gallium 68 dotatate (68Ga-DOTA) scanning is at the center of a discussion about how these imaging technologies can modify clinical management of neuroendocrine tumors and how their results are correlated to Ki67 index. Method We hereby describe a case of a patient that investigated an unspecific stable pancreatic nodule suspected of high-grade NET after evaluation with 68Ga-DOTATOC positron emission tomography—computed tomography (PETCT) and 18F-Fluorodeoxyglucose (18F-FDG) PETCT. Results The images corroborate the hypothesis of high-grade NET based on the standard uptake value (SUV) described in both image exams (16.4 in 18FDG PETCT and 9.2 in 68Ga-DOTATOC PETCT). After surgery, the histopathological analyses revealed a localized grade 2 well-differentiated NET, Ki-67 of 4.7, glucose transport proteins 1 (GLUT1) negative by immunohistochemistry, evidencing a rare case of mismatch between the functional image and the in vivo characterization of the neoplasm. Conclusion Functional imaging of neuroendocrine tumors with different modalities of PETCT is a well-described strategy for evaluating PNET and can dictate conducts in some cases. However, histopathological analysis is crucial to confirm the grade and prognosis related to this disease.

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“…As previously mentioned, NETs (G1 and G2) normally express SSTR on the cell surface, while the SSTR decreases when tumors become less differentiated and more aggressive. With the decline in SSTR expression, cell glucose utilization increases (8). In 18 F-fluorodeoxyglucose PET/CT (18-F-FDG-PET/CT) images, FDG, as a glucose analog, could visualize glucose metabolic activity.…”

Section: Case Presentationmentioning

confidence: 99%

Mixed neuroendocrine nonneuroendocrine neoplasms of the pancreas: a case report and literature review of pancreatic mixed neuroendocrine nonneuroendocrine neoplasm

Wang¹,

Lou²,

Qin³

et al. 2021

Gland Surg

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A 36-year-old woman underwent left lateral hepatic lobectomy and tumor enucleation of the pancreatic head due to the diagnosis of mixed neuroendocrine nonneuroendocrine neoplasms (MiNENs).Her past medical history revealed an ill-defined mass in the pancreatic uncinate (approximately 1 cm in size) and liver nodules in segment II, suggesting a pancreatic neuroendocrine tumor (pNET) and liver metastases.After the operation, pathological examination showed that the lesion in the pancreas was MiNEN. The neuroendocrine component consisted of grade 1 (G1) NETs, and the nonneuroendocrine part was welldifferentiated adenocarcinoma. Additionally, in hepatic lesions, the type of pancreaticobiliary duct in moderately differentiated adenocarcinoma indicated the source of tumor cells. We present the following case in accordance with the CARE reporting checklist. MiNENs of the pancreas are extremely rare and heterogeneous malignancies. Owing to the rarity of pancreatic MiNEN, no structured guidelines on preoperative diagnostics, therapy and follow-up exist thus far. Thus, problems in differential diagnosis and appropriate therapy may arise when treating suspected MiNEN patients. We performed a rigorous search on pancreatic MiNEN via PubMed and Web of Science. In total, 167 studies were identified, and 28 cases in 15 studies about pancreatic MiNEN were assessed. All the available information was listed and fully discussed.

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Ga-68 DOTA-peptides and F-18 FDG PET/CT in patients with neuroendocrine tumor: A review

Cited by 40 publications

References 24 publications

Development and long-term evaluation of a new 68Ge/68Ga generator based on nano-SnO2 for PET imaging

Development and long-term evaluation of a new 68Ge/68Ga generator based on nano-SnO2 for PET imaging

18F-FDG PETCT and 68Ga-DOTA PETCT mismatch with in vivo histopathological characterization of low-grade neuroendocrine pancreatic tumor

Mixed neuroendocrine nonneuroendocrine neoplasms of the pancreas: a case report and literature review of pancreatic mixed neuroendocrine nonneuroendocrine neoplasm

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