Ga-68-DOTA-TATE PET/CT for Discrimination of Tumors of the Optic Pathway

Abstract

Ga-68-DOTA-TATE PET/CT proved to be a valuable diagnostic tool for the correct classification of equivocal, symptomatic tumors of the anterior optic pathway requiring therapy. PET/CT results influenced therapy decision essentially in all cases.

Combined positron emission tomography/computed tomography for diagnosis and monitoring of orbital adnexal lymphoma

“…[68 Ga]‐DOTA‐TATE (68‐Ga‐1,4,7,10‐tetraazacyclododecane‐ N , N ’, N ’’, N ’’’‐tetraacetic acid‐d‐Phe(1),Tyr(3)‐octreotate) has proven invaluable for non‐invasive diagnostics of meningioma (Klingenstein et al. ).…”

“…Different radiopharmaceutical tracers have given evidence of proving metabolic lineage of orbital metastases (Klingenstein et al 2016). [68 Ga]-DOTA-TATE (68- 4,7,N',N'', acid-d-Phe(1), Tyr(3)-octreotate) has proven invaluable for non-invasive diagnostics of meningioma (Klingenstein et al 2015).…”

Leitsymptom Protrusio bulbi – diagnostisches Management

“…Unsere Gruppe hat in der Ophthalmologie bereits vom erfolgversprechenden Einsatz der kombinierten FDG-PET/CT (FDG: 18 F-Fluor-Desoxyglukose) bei der Metastasendetektion von Aderhautmelanompatienten [13], der Detektion orbitaler Tumoren mittels verschiedener Tracer [14] und vom Einsatz der 68 Ga-DOTA-TATE-PET/CT ( 68 Ga-1,4,7,10-tetraazacyclododecan-N,N′,N′′, N′′′-tetraessigsäure Phe(1)Tyr(3)-Octreotat) in der Meningeomdiagnostik berichtet [15]. ▶ Abb.…”

Combined positron emission tomography/computed tomography (PET/CT) for imaging of orbital tumours and tumours extending into the orbit

“…While PET/CT has already been considered as a new method for diagnosing, staging, and restaging patients with orbital lymphoma,14 the advantage in solid orbital tumours is regarded controversial 15. Our study group has reported on (68Ga)-DOTA-TATE PET/CT as a useful tool in imaging orbital meningiomas previously 12. The objective of the current study was to evaluate the performance of the combined PET/CT scanner in patients with primary and secondary solid orbital tumours.…”

“…(68Ga)-DOTATATE (68-Ga-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid-d-Phe(1),Tyr(3)-octreotate), a selective somatostatin receptor (SSTR) agonist,12 is applied for the detection of meningioma or neuroendocrine tumours. For imaging of other tumour entities that might metastasise to the orbit, specific radiopharmaceutical tracers such as, for example, (18F)-fluoroethylcholine ((18F)-FEC) or (68Ga)-PSMA (prostate-specific membrane antigen) in prostate cancer are applied regularly in clinical routine among others 13…”