Gab1 Overexpression Attenuates Susceptibility to Ventricular Arrhythmias in Pressure Overloaded Heart Failure Mouse Hearts

Identification of novel prognostic targets in coronary artery disease and related complications using bioinformatics and next generation sequencing data analysis

“…DOCK4 [58], CEACAM1 [59], STAT1 [60], ARG1 [61], TLR4 [62], ADAM9 [63], VNN1 [64], ABCA1 [65], STAT2 [66], TLR5 [67], PTGS2 [68], RNF213 [69], ZDHHC17 [70], JAK2 [71], TLR8 [72], NOTCH2 [73], PDGFC (platelet derived growth factor C) [74], CMPK2 [75], TLR2 [76], CYP1B1 [77], CCR1 [78], HDAC9 [79], IL1RN [80], GCH1 [81], LYST (lysosomal trafficking regulator) [82], PELI1 [83], EGR1 [84], SNX10 [85], CA2 [86], ZEB2 [87], HIF1A [88], PLA2G7 [89], CCR2 [90], GAB1 [91], IRAK3 [92], LDLR (low density lipoprotein receptor) [93], TLR6 [94], SIRT1 [95], NOD2 [96], ATP10D [97], ELOVL6 [98], VCAN (versican) [99], TET2 [100], TET3 [101], ZBTB20 [102], HS3ST1 [103], PF4 [104], DNAJC2 [105], NFIA (nuclear factor I A) [106], CCR7 [107], PRDX2 [108], ADK (adenosine kinase) [109], TCF7 [110], LGALS3 [111], OLFM2 [112], HDAC11 [113] and ARPC1B [114] are significantly related to the atherosclerosis. Studies have revealed that KCNJ2 [115], TLR4 [116], JAK2 [117], TLR2 [118], EGR1 [119], GAB1 [120], ZBTB11 [121], BIN1 [122], TCF4 [123], PPP1R13L [124], TRPM4 [125], LGALS3 [126] and SNTA1 [127] plays a key role in cardiac arrhythmia. Recently, increasing evidence demonstrated that KCNJ2 [128], TLR4 [129], CYP2D6 [130], TLR2 [129], SNX10 [131], SIRT1 [132<...…”

“…Altered expression of ATOH8 [364], STAT1 [365], ARG1 [366], TLR4 [367], VNN1 [368], ABCA1 [369], IFIH1 [370], PTGS2 [371], F2RL1 [289], CYP2D6 [372], PDK4 [373], RNF213 [374], JAK2 [375], NOTCH2 [376], PDGFC (platelet derived growth factor C) [377], TLR2 [378], CYP1B1 [379], IL1RN [380], GCH1 [381], EGR1 [382], HIF1A [383], PLA2G7 [384], CCR2 [385], GAB1 [386], VEGFA (vascular endothelial growth factor A) [387], OGT (O-linked N-acetylglucosamine (GlcNAc) transferase) [388], OXR1 [389], IRF9 [390], FMR1 [391], LDLR (low density lipoprotein receptor) [392], SIRT1 [393], NOD2 [394], ATP13A3 [395], VCAN (versican) [396], FGL2 [397], TET2 [398], KDM6A [399], KLHL2 [400], CAVIN1 [401], TNFRSF4 [402], PF4 [403], VEGFB (vascular endothelial growth factor B) [330], CCR7 [404], PRDX2 [405], HSPB1 [406], TCF4 [407], MRPL4 [408], PHF14 [409], TRPM4 [410], AQP3 [411] and LGMN (legumain) [412] were observed to be associated with the progression of hypertension. Recent studies have shown that altered expression of DDX58 [413], STAT1 [414], TLR4 [415], CYP2D6 [416], JAK2 [417], TLR2 [418], DUSP6 [419], HDAC9 [420], LATS2 [421], CA2 [150], HIPK3 [422], CCR2 [423], GAB1 [120], UFL1 [424], OGT (O-linked N-acetylglucosamine (GlcNAc) transferase) [425], PRKAR1A [265], SIRT1 [426], FGL2 [427], TET2 [428], ASCC2 [429], BIN1 [430], HSPB1 […”

“…We discovered that that EGR1 was targeted by 53 TFs (ex; LMO2); DDX5 was targeted by 51 TFs (ex; MYCN); NCOA3 was targeted by 48 TFs (ex; SIN3B); STAT1 was targeted by 42 TFs (ex; IRF8); HIF1A was targeted by 40 TFs (ex; GATA1); RPS14 was targeted by 45 TFs (ex; RCOR3); RPL3 was targeted by 44 TFs (ex; DMRT1); RPS19 was targeted by 42 TFs (ex; GCH1 [81], LYST (lysosomal trafficking regulator) [82], PELI1 [83], EGR1 [84], SNX10 [85], CA2 [86], ZEB2 [87], HIF1A [88], PLA2G7 [89] [105], NFIA (nuclear factor I A) [106], CCR7 [107], PRDX2 [108], ADK (adenosine kinase) [109], TCF7 [110], LGALS3 [111], OLFM2 [112], HDAC11 [113] and ARPC1B [114] are significantly related to the atherosclerosis. Studies have revealed that KCNJ2 [115], TLR4 [116], JAK2 [117], TLR2 [118], EGR1 [119], GAB1 [120], ZBTB11 [121], BIN1 [122], TCF4 [123], PPP1R13L [124], TRPM4 [125], LGALS3 [126] and SNTA1 [127] plays a key role in cardiac arrhythmia. Recently, increasing evidence demonstrated that KCNJ2 [128], TLR4 [129], CYP2D6 [130], TLR2 [129], SNX10 [131], SIRT1 [132], PF4 [133], PCYT2 [134] and LGALS3 [135] were altered expression in atrial fibrillation.…”