GABA-A and GABA-B receptors mediate feeding elicited by the GABA-B agonist baclofen in the ventral tegmental area and nucleus accumbens shell in rats: Reciprocal and regional interactions

Miner, Patricia; Borkuhova, Yaffa; Shimonova, Lyudmila; Khaimov, Arthur; Bodnar, Richard J.

doi:10.1016/j.brainres.2010.07.109

Cited by 20 publications

(11 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering that optogenetic stimulation of VTA GABA neurons impairs natural reward consumption (van Zessen et al 2012), it is somewhat surprising that effects on food- reinforced responding were not observed. However, consistent with our findings, others have reported that GABA A and GABA B receptor antagonism in the VTA has minimal effects on feeding behavior (Echo et al 2002; Ackerman et al 2003; Miner et al 2010). When interpreting these findings, it is important to note that the rates of responding during the food-reinforced sessions (approximately 30 responses/minute) were much higher than those during the reinstatement sessions.…”

Section: Discussionsupporting

confidence: 93%

“…The GABA B receptor antagonist 2-hydroxysaclofen was also purchased from Tocris Bioscience and was administered at doses of 0.2 and 2 µg/side (0.75 and 7.5 nmol/side) dissolved in aCSF (0.25 µl/side). The doses used were also selected based on prior reports assessing VTA effects (Xi and Stein, 1999; Echo et al 2002; Ackerman et al 2003; Miner et al 2010). …”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Antagonism of GABA-B but not GABA-A receptors in the VTA prevents stress- and intra-VTA CRF-induced reinstatement of extinguished cocaine seeking in rats

et al. 2016

View full text Add to dashboard Cite

Stress-induced reinstatement of cocaine seeking requires corticotropin releasing factor (CRF) actions in the ventral tegmental area (VTA). However the mechanisms through which CRF regulates VTA function to promote cocaine use are not fully understood. Here we examined the role of GABAergic neurotransmission in the VTA mediated by GABA-A or GABA-B receptors in the reinstatement of extinguished cocaine seeking by a stressor, uncontrollable intermittent footshock, or bilateral intra-VTA administration of CRF. Rats underwent repeated daily cocaine self-administration (1.0 mg/kg/ing; 14 × 6 hrs/day) and extinction and were tested for reinstatement in response to footshock (0.5 mA, 0.5” duration, average every 40 sec; range 10–70 sec) or intra-VTA CRF delivery (500 ng/side) following intra-VTA pretreatment with the GABA-A antagonist, bicuculline, the GABA-B antagonist, 2-hydroxysaclofen or vehicle. Intra-VTA bicuculline (1, 10 or 20 ng/side) failed to block footshock- or CRF-induced cocaine seeking at either dose tested. By contrast, 2-hydroxysaclofen (0.2 or 2 µg/side) prevented reinstatement by both footshock and intra-VTA CRF at a concentration that failed to attenuate food-reinforced lever pressing (45 mg sucrose-sweetened pellets; FR4 schedule) in a separate group of rats. These data suggest that GABA-B receptor-dependent CRF actions in the VTA mediate stress-induced cocaine seeking and that GABA-B receptor antagonists may have utility for the management of stress-induced relapse in cocaine addicts.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Antagonism of GABA-B but not GABA-A receptors in the VTA prevents stress- and intra-VTA CRF-induced reinstatement of extinguished cocaine seeking in rats

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Recently, food intake has been reported to be regulated by a network in the brain that included not only VMH and the lateral hypothalamus, but also other sites in the limbic system of the brain. Involvement of GABAergic neurons in this network has been suggested in the control of feeding responses (both elicitation and suppression) by bidirectional interactions between sites [33]. Because much lower doses of 2,3,7,8-TetraCDD affect on development of GABAergic neurons [28], prenatal and postnatal exposure of dioxins at environmental exposure level might affect GABAergic neurons in the brain network that control food intake and induce appetite loss leading to decreased weight gain in human offspring.…”

Section: Discussionmentioning

confidence: 99%

Impact of Perinatal Dioxin Exposure on Infant Growth: A Cross-Sectional and Longitudinal Studies in Dioxin-Contaminated Areas in Vietnam

et al. 2012

View full text Add to dashboard Cite

Dioxin exposure levels remain elevated in residents living around former US Air Force bases in Vietnam, indicating potential adverse impacts on infant growth. In this study, 210 mother–infant pairs in dioxin-contaminated areas in Vietnam were recruited at the infants’ birth and followed up for 4 months. Perinatal dioxin exposure levels were estimated by measurement of polychlorinated dibenzo-p-dioxins/furans toxic equivalent (PCDDs/Fs-TEQ) in breast milk. The infants’ size was measured at birth and 1 and 4 months after birth, and neurodevelopment was evaluated using the Bayley Scales III at 4 months of age. Among 4 dioxin groups (<25, 25–50, 50–75, ≥75 percentile of PCDDs/Fs-TEQ), cross-sectional comparisons of body size and neurodevelopment scales and comparisons of longitudinally assessed body size were performed respectively. At birth, head circumference of girls in the ≥75 percentile group was significantly larger than those in the <25 and 50–75 percentile groups. At 4 months of age, the weight and body mass index (BMI) of boys in the ≥75 percentile group were significantly lower than those in the other groups. Increase in weight was significantly lower in the ≥75 percentile group in both sexes from birth to 1 month but only in boys at 1–4 months of age. Estimated marginal mean values in a mixed model of weight and BMI during the first 4 months of life were significantly lower in the ≥75 percentile group in boys. In girls, marginal mean values for head circumference were increased with increase in dioxin levels. Only in boys, cognitive, language, and fine motor scores in the ≥75 percentile group were significantly lower than those in the other groups. These results suggested a considerable impact of perinatal dioxin exposure on infant growth, particularly in boys exposed to dioxins at high level of PCDDs/Fs-TEQ.

show abstract

“…Two areas in the ventral striatum - nucleus accumbens (NAc) and ventral pallidum (VP), along with a midbrain area - the ventral tegmental area (VTA) - have been implicated in the hedonic aspects of food intake, alcohol consumption, and drug addiction (Feltenstein and See, 2008, Soderpalm et al, 2009, Miner et al, 2010). The dopamine-containing neurons of the VTA are part of the reward system, and they project to the NAc and VP; this system has been termed the dopamine mesolimbic pathway (Sesack and Grace, 2010), and several recent reviews have been published on this subject (Saper et al, 2002, Voorn et al, 2004, Pecina et al, 2006, Fields et al, 2007, Smith et al, 2009, Sesack and Grace, 2010, Zellner and Ranaldi, 2010).…”

Section: Discussionmentioning

confidence: 99%

FoxP2 brainstem neurons project to sodium appetite regulatory sites

Shin

Geerling

Stein

et al. 2011

Journal of Chemical Neuroanatomy

View full text Add to dashboard Cite

The transcription factor Forkhead box protein 2 (FoxP2) is expressed in two cell groups of the brainstem that have been implicated in sodium appetite regulation: the pre-locus coeruleus (pre-LC) and parabrachial nucleus - external lateral-inner subdivision (PBel-inner). Because the connections of these two groups are unknown, neuroanatomical tracing methods were used to define their central projections. The pre-LC outputs were first analyzed using an anterograde axonal tracer - Phaseolus vulgaris leucoagglutinin (PHAL) to construct a brain map. Next, we examined whether the FoxP2 immunoreactive (FoxP2+) neurons of the pre-LC contribute to these projections using a retrograde neuronal tracer - cholera toxin β-subunit (CTb). CTb was injected into selected brain regions identified in the anterograde tracing study. One week later the rats were killed, and brainstem sections were processed by a double immunohistochemical procedure to determine whether the FoxP2+ neurons in the pre-LC and/or PBel-inner contained CTb. FoxP2+ pre-LC neurons project to: 1) ventral pallidum; 2) substantia innominata and bed nucleus of the stria terminalis; 3) paraventricular, central medial, parafascicular, and subparafascicular parvicellular thalamic nuclei; 4) paraventricular (PVH), lateral, perifornical, dorsomedial (DMH), and parasubthalamic hypothalamic nuclei; and 5) ventral tegmental area (VTA), periaqueductal gray matter (PAG), dorsal and central linear raphe nuclei. FoxP2+ PBel-inner neurons project to the PVH and DMH, with weaker connections to the LHA, VTA, and PAG. Both the pre-LC and PBel-inner project to central sites implicated in sodium appetite, and related issues, including foraging behavior, hedonic responses to salt intake, sodium balance, and cardiovascular regulation, are discussed.

show abstract

GABA-A and GABA-B receptors mediate feeding elicited by the GABA-B agonist baclofen in the ventral tegmental area and nucleus accumbens shell in rats: Reciprocal and regional interactions

Cited by 20 publications

References 61 publications

Antagonism of GABA-B but not GABA-A receptors in the VTA prevents stress- and intra-VTA CRF-induced reinstatement of extinguished cocaine seeking in rats

Antagonism of GABA-B but not GABA-A receptors in the VTA prevents stress- and intra-VTA CRF-induced reinstatement of extinguished cocaine seeking in rats

Impact of Perinatal Dioxin Exposure on Infant Growth: A Cross-Sectional and Longitudinal Studies in Dioxin-Contaminated Areas in Vietnam

FoxP2 brainstem neurons project to sodium appetite regulatory sites

Contact Info

Product

Resources

About