GABA: a key player of abiotic stress regulation

GABA in plants: developmental and stress resilience perspective

“…GABA is also known to regulate the biosynthesis of various primary and secondary metabolites to promote stress tolerance (Mazzucotelli et al, 2006;Fait et al, 2008;Renault et al, 2011;Krasensky et al, 2012;Bown et al, 2016;Ramos-ruiz et al, 2019;Gong et al, 2020;Li et al, 2021;Mishra et al, 2023). In this review article, we have focused our attention on the role of GABA in regulating developmental and stress resilience aspects in plants.…”

“…Gamma‐aminobutyric acid (GABA) is a four‐carbon‐containing non‐proteinogenic amino acid that is ubiquitous in nature. It is found in a wide range of organisms ranging from prokaryotes to eukaryotes (Bouche et al, 2004; Mazzucotelli et al, 2006; Renault et al, 2011; Michaeli et al, 2015; Ramos‐Ruiz et al, 2019; Gong et al, 2020; Sita et al, 2020; Mishra et al, 2023). The credit for the discovery of GABA goes to Eugene Robert and Sam Frankel who, in 1950, reported the presence of a major amine in the brain which was subsequently identified as GABA in 1957 (Spiering et al, 2018).…”

“…Thereafter, continuous ongoing research has proven GABA as a key regulator of plant growth and development (Mazzucotelli et al, 2006; Krasensky et al, 2012; Bown et al, 2016; Sita et al, 2020; Li et al, 2021; Hasan et al, 2021; Mishra et al, 2023). Moreover, the involvement of GABA in the abiotic and biotic stress tolerance has also been reported; for instance, during drought (Abdel et al, 2021), heavy metals (Sita et al, 2020), salinity (Sita et al, 2020), flooding (Shiu et al, 2020) and pathogenic attack (Yang et al, 2017), among others (Mazzucotelli et al, 2006; Renault et al, 2011; Bown et al, 2016; Sita et al, 2020; Li et al, 2021; Hasan et al, 2021; Mishra et al, 2023). Its protective role is mainly achieved by modifying the photosynthetic activity (Sita et al, 2020), reprogramming C/N metabolism (Krasensky et al, 2012;), regulating stomatal conductance (Hasan et al, 2021), and maintaining reactive oxygen species (ROS) homeostasis (Shelp et al, 1999; Krasensky et al, 2012; Sita et al, 2020; Hasan et al, 2021; Li et al, 2021).…”

“…In plants, GABA was first reported in Solanum tuberosum about half a century ago (Roberts et al, 1984; Spiering et al, 2018). Thereafter, continuous ongoing research has proven GABA as a key regulator of plant growth and development (Mazzucotelli et al, 2006; Krasensky et al, 2012; Bown et al, 2016; Sita et al, 2020; Li et al, 2021; Hasan et al, 2021; Mishra et al, 2023). Moreover, the involvement of GABA in the abiotic and biotic stress tolerance has also been reported; for instance, during drought (Abdel et al, 2021), heavy metals (Sita et al, 2020), salinity (Sita et al, 2020), flooding (Shiu et al, 2020) and pathogenic attack (Yang et al, 2017), among others (Mazzucotelli et al, 2006; Renault et al, 2011; Bown et al, 2016; Sita et al, 2020; Li et al, 2021; Hasan et al, 2021; Mishra et al, 2023).…”

“…Its protective role is mainly achieved by modifying the photosynthetic activity (Sita et al, 2020), reprogramming C/N metabolism (Krasensky et al, 2012;), regulating stomatal conductance (Hasan et al, 2021), and maintaining reactive oxygen species (ROS) homeostasis (Shelp et al, 1999; Krasensky et al, 2012; Sita et al, 2020; Hasan et al, 2021; Li et al, 2021). GABA is also known to regulate the biosynthesis of various primary and secondary metabolites to promote stress tolerance (Mazzucotelli et al, 2006; Fait et al, 2008; Renault et al, 2011; Krasensky et al, 2012; Bown et al, 2016; Ramos‐ruiz et al, 2019; Gong et al, 2020; Li et al, 2021; Mishra et al, 2023). In this review article, we have focused our attention on the role of GABA in regulating developmental and stress resilience aspects in plants.…”