GABA concentrations in the anterior cingulate and dorsolateral prefrontal cortices: Associations with chronic cigarette smoking, neurocognition, and decision making

Durazzo, Timothy C.; Meyerhoff, Dieter J.

doi:10.1111/adb.12948

Cited by 7 publications

(4 citation statements)

References 53 publications

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“…Our group showed that a decrease in hippocampal cholinergic parameters, induced by insults such as thiamine deficiency and/or ethanol consumption, interferes with aspects of spatial reference memory [11]. There are several articles in the literature showing evidence of GABA involvement in spatial cognitive functions [4,10,13,23,24]. However, to our knowledge, the present study is the first to show evidence of a significant effect of training on a spatial navigation task on GABA levels in the hippocampus.…”

Section: Discussionsupporting

confidence: 45%

Acquisition of a spatial navigation task in the padding pool induces an increase of GABA level in the hippocampus of Swiss mice

Romano¹,

Ribeiro²

2021

GSC Adv. Res. Rev.

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The balance between excitatory and inhibitory glutamatergic and GABAergic systems, respectively, is crucial for the maintenance of complex cognitive functions such as learning. Using Swiss mice as experimental model, the aims of the present study were to evaluate cognitive performance in a shallow water maze (SWM) and the effects of training in this spatial navigation task on hippocampal GABA and glutamate levels. In addition, correlations between neurochemical and behavioural data, and between glutamate and GABA levels were assessed. Forty-six three-month-old mice were divided into three groups: Learning, n=18: animals submitted to the SWM task; Active, n=14: animals exposed to the SWM, without the demand of performing a cognitive task and Control, n=14: the animals were kept in the vivarium without contact with the SWM. There was significant training effect indicating that the Learning group animals have learned the task. Regarding neurochemical data, the findings of the present work show for the first time that the task learning process in SWM has a significant effect on GABA levels in the hippocampus. The relationship between the two neurotransmitters, observed in the control animals, was adjusted by a significant increase in hippocampal GABA levels caused by the spatial training performed by the animals from the Learning group. However, the relationship observed in control condition is disrupted by a subsequent exposure to the maze in the absence of a spatial cognitive demand, as was the case of the Active group. These data open new perspectives to explore the involvement of the inhibitory and excitatory systems in the molecular mechanisms associated with different types and steps of learning processes.

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Section: Discussionsupporting

confidence: 45%

Acquisition of a spatial navigation task in the padding pool induces an increase of GABA level in the hippocampus of Swiss mice

Romano¹,

Ribeiro²

2021

GSC Adv. Res. Rev.

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“…The data illustrate that across all levels of NHP ethanol consumption, imposed abstinence increased consumption when ethanol was reintroduced. The approximately 4 weeks of abstinence was modeled after the most common inpatient treatment protocol for severe AUD [8]. Escalated drinking, as seen in the return to heavy drinking following imposed abstinence, is a hallmark symptom of the addiction cycle [67] and is commonly modeled in rodents [68].…”

Section: Advances In Drug and Alcohol Researchmentioning

confidence: 99%

“…The dorsolateral prefrontal cortex (DLPFC) is implicated in the return to heavy drinking in subjects with AUD, particularly in terms of volumetric analyses with magnetic resonance imaging (MRI) predicting sustained abstinence [8]. Indeed, subjects who returned to heavy drinking after 4 weeks of abstinence showed recovery of frontal cortical volume compared to subjects who maintained abstinence [8]. This suggests that atrophy of the DLPFC seen in relapsing AUD is due to underlying aberrant neuroadaptation to chronic heavy drinking.…”

Section: Introductionmentioning

confidence: 99%

Effects of repeated alcohol abstinence on within-subject prefrontal cortical gene expression in rhesus macaques

Hitzemann,

Gao,

Fei

et al. 2024

Adv. Drug Alcohol Res.

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Male rhesus monkeys (n = 24) had a biopsy of prefrontal cortical area 46 prior to chronic ethanol self-administration (n = 17) or caloric control (n = 7). Fourteen months of daily self-administration (water vs. 4% alcohol, 22 h access/day termed “open-access”) was followed by two cycles of prolonged abstinence (5 weeks) each followed by 3 months of open-access alcohol and a final abstinence followed by necropsy. At necropsy, a biopsy of Area 46, contralateral to the original biopsy, was obtained. Gene expression data (RNA-Seq) were collected comparing biopsy/necropsy samples. Monkeys were categorized by drinking status during the final post-abstinent drinking phase as light (LD), binge (BD), heavy (HD) and very heavy (VHD drinkers). Comparing pre-ethanol to post-abstinent biopsies, four animals that converted from HD to VHD status had significant ontology enrichments in downregulated genes (necropsy minus biopsy n = 286) that included immune response (FDR < 9 × 10−7) and plasma membrane changes (FDR < 1 × 10−7). Genes in the immune response category included IL16 and 18, CCR1, B2M, TLR3, 6 and 7, SP2 and CX3CR1. Upregulated genes (N = 388) were particularly enriched in genes associated with the negative regulation of MAP kinase activity (FDR < 3 × 10−5), including DUSP 1, 4, 5, 6 and 18, SPRY 2, 3, and 4, SPRED2, BMP4 and RGS2. Overall, these data illustrate the power of the NHP model and the within-subject design of genomic changes due to alcohol and suggest new targets for treating severe escalated drinking following repeated alcohol abstinence attempts.

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“…It is worth mentioning that these neurotransmitters with trace amounts in the brain can be specifically and reliably detected by the J ‐edited (MEGA‐PRESS) technology (Menshchikov et al, 2017; Mescher et al, 1998). A recent study (Durazzo & Meyerhoff, 2021) on chronic cigarette smoking found that smokers had significantly lower GABA levels in the right DLPFC than nonsmokers, and demonstrated that GABA concentrations in ACC and DLPFC were associated with neurocognition and decision‐making/impulsivity in active cigarette smokers. Previous study by Janes et al (2013) also revealed a relationship of the heightened reactivity to drug cues with both decreasing dorsolateral ACC GABA in smoker and early withdrawal symptoms.…”

Section: Introductionmentioning

confidence: 99%

Changes in aspartate metabolism in the medial‐prefrontal cortex of nicotine addicts based on J‐edited magnetic resonance spectroscopy

Yu,

Lin,

et al. 2023

Human Brain Mapping

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This study aims to explore the changes of the aspartate (Asp) level in the medial‐prefrontal cortex (mPFC) of subjects with nicotine addiction (nicotine addicts [NAs]) using the J‐edited 1H MR spectroscopy (MRS), which may provide a positive imaging evidence for intervention of NA. From March to August 2022, 45 males aged 40–60 years old were recruited from Henan Province, including 21 in NA and 24 in nonsmoker groups. All subjects underwent routine magnetic resonance imaging (MRI) and J‐edited MRS scans on a 3.0 T MRI scanner. The Asp level in mPFC was quantified with reference to the total creatine (Asp/Cr) and water (Aspwater‐corr, with correction of the brain tissue composition) signals, respectively. Two‐tailed independent samples t‐test was used to analyze the differences in levels of Asp and other coquantified metabolites (including total N‐acetylaspartate [tNAA], total cholinine [tCho], total creatine [tCr], and myo‐Inositol [mI]) between the two groups. Finally, the correlations of the Asp level with clinical characteristic assessment scales were performed using the Spearman criteria. Compared with the control group (n = 22), NAs (n = 18) had higher levels of Asp (Asp/Cr: p = .005; Aspwater‐corr: p = .004) in the mPFC, and the level of Asp was positively correlated with the daily smoking amount (Asp/Cr: p < .001; Aspwater‐corr: p = .004). No significant correlation was found between the level of Asp and the years of nicotine use, Fagerstrom Nicotine Dependence (FTND), Russell Reason for Smoking Questionnaire (RRSQ), or Barratt Impulsivity Scale (BIS‐11) score. The elevated Asp level was observed in mPFC of NAs in contrast to nonsmokers, and the Asp level was positively correlated with the amount of daily smoking, which suggests that nicotine addiction may result in elevated Asp metabolism in the human brain.

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GABA concentrations in the anterior cingulate and dorsolateral prefrontal cortices: Associations with chronic cigarette smoking, neurocognition, and decision making

Cited by 7 publications

References 53 publications

Acquisition of a spatial navigation task in the padding pool induces an increase of GABA level in the hippocampus of Swiss mice

Acquisition of a spatial navigation task in the padding pool induces an increase of GABA level in the hippocampus of Swiss mice

Effects of repeated alcohol abstinence on within-subject prefrontal cortical gene expression in rhesus macaques

Changes in aspartate metabolism in the medial‐prefrontal cortex of nicotine addicts based on J‐edited magnetic resonance spectroscopy

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