GABA in the central amygdaloid nucleus modulates the electrolyte excretion and hormonal responses to blood volume expansion in rats

Margatho, Lisandra Oliveira; Elias, Lucila Leico Kagohara

doi:10.1590/s0100-879x2009000100016

Cited by 5 publications

(4 citation statements)

References 36 publications

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“…We have previously shown that, in rats pre‐treated with the GABAergic agonist muscimol in the CeA, which is rich in GABA A receptors, there was a reduction in plasma OT and ANP hormone levels, as well as in sodium excretion and urine output in response to hypertonic BVE. These responses are similar to the effects of the OT receptor antagonist OVT in the CeA on the BVE and OT induced responses observed in the present study.…”

Section: Discussionmentioning

confidence: 97%

“…Margatho et al . also showed that the involvement of GABAergic mechanisms within the CeA is related to the control of urinary electrolyte excretion and hormone release in rats subjected to acute isotonic or hypertonic BVE. It was observed that in response to BVE, a previous injection of muscimol into the CeA inhibited the synaptic inputs mediated by the perinuclear GABAergic interneurones in the Pa and SON.…”

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confidence: 87%

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Oxytocin in the Central Amygdaloid Nucleus Modulates the Neuroendocrine Responses Induced by Hypertonic Volume Expansion in the Rat

Margatho

Elias

et al. 2013

J Neuroendocrinology

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The present study investigated the involvement of the oxytocinergic neurones that project into the central amygdala (CeA) in the control of electrolyte excretion and hormone secretion in unanaesthetised rats subjected to acute hypertonic blood volume expansion (BVE; 0.3 M NaCl, 2 ml/100 g of body weight over 1 min). Oxytocin and vasopressin mRNA expression in the paraventricular (Pa) and supraoptic nucleus (SON) of the hypothalamus were also determined using the real time-polymerase chain reaction and in situ hybridisation. Male Wistar rats with unilaterally implanted stainless steel cannulas in the CeA were used. Oxytocin (1 μg/0.2 μl), vasotocin, an oxytocin antagonist (1 μg/0.2 μl) or vehicle was injected into the CeA 20 min before the BVE. In rats treated with vehicle in the CeA, hypertonic BVE increased urinary volume, sodium excretion, plasma oxytocin (OT), vasopressin (AVP) and atrial natriuretic peptide (ANP) levels and also increased the expression of OT and AVP mRNA in the Pa and SON. In rats pre-treated with OT in the CeA, previously to the hypertonic BVE, there were further significant increases in plasma AVP, OT and ANP levels, urinary sodium and urine output, as well as in gene expression (AVP and OT mRNA) in the Pa and SON compared to BVE alone. Vasotocin reduced sodium, urine output and ANP levels, although no changes were observed in plasma AVP and OT levels or in the expression of the AVP and OT genes in both hypothalamic nuclei. The results of the present study suggest that oxytocin in the CeA exerts a facilitatory role in the maintenance of hydroelectrolyte balance in response to changes in extracellular volume and osmolality.

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Section: Discussionmentioning

confidence: 97%

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confidence: 87%

Oxytocin in the Central Amygdaloid Nucleus Modulates the Neuroendocrine Responses Induced by Hypertonic Volume Expansion in the Rat

Margatho

Elias

et al. 2013

J Neuroendocrinology

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“…Furthermore, increases in urine output, renal sodium excretion, and plasma OT and ANP concentrations induced by isotonic and hypertonic EVE are attenuated in rats pretreated with muscimol into the CeA. Bicuculline, an antagonist of GABA A receptors, injected into the CeA, also reduced the effects of hypertonic EVE on urinary volume and ANP secretion 39. Thus, taken together, these data suggest that the CeA GABAergic mechanisms are involved in the control of ANP and OT secretion, as well as in the control of sodium and water excretion in response to isotonic and hypertonic increases in the ECF.…”

Section: Main Neural Pathways Involved In the Regulation Of Ecf Volummentioning

confidence: 95%

Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis

Antunes‐Rodrigues

Ruginsk

Mecawi

et al. 2013

Braz J Med Biol Res

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Several forebrain and brainstem neurochemical circuitries interact with peripheral neural and humoral signals to collaboratively maintain both the volume and osmolality of extracellular fluids. Although much progress has been made over the past decades in the understanding of complex mechanisms underlying neuroendocrine control of hydromineral homeostasis, several issues still remain to be clarified. The use of techniques such as molecular biology, neuronal tracing, electrophysiology, immunohistochemistry, and microinfusions has significantly improved our ability to identify neuronal phenotypes and their signals, including those related to neuron-glia interactions. Accordingly, neurons have been shown to produce and release a large number of chemical mediators (neurotransmitters, neurohormones and neuromodulators) into the interstitial space, which include not only classic neurotransmitters, such as acetylcholine, amines (noradrenaline, serotonin) and amino acids (glutamate, GABA), but also gaseous (nitric oxide, carbon monoxide and hydrogen sulfide) and lipid-derived (endocannabinoids) mediators. This efferent response, initiated within the neuronal environment, recruits several peripheral effectors, such as hormones (glucocorticoids, angiotensin II, estrogen), which in turn modulate central nervous system responsiveness to systemic challenges. Therefore, in this review, we shall evaluate in an integrated manner the physiological control of body fluid homeostasis from the molecular aspects to the systemic and integrated responses.

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“…Cofiel and Mattioli (3), also using L-histamine, evaluated the role of the histaminergic system in learning and stress and showed its importance in the modulation of these responses in zebrafish. The study by Margatho et al (4) suggested that central amygdala GABAergic mechanisms are involved in atrial natriuretic peptide and oxytocin secretion in response to blood volume expansion. Nascimento and Branco (5) suggested an interesting synergism between peripheral and spinal heme oxygenase-carbon monoxide pathways that may play an antinociceptive role.…”

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IV Miguel R. Covian Symposium: new challenges for physiologists

Machado¹

2009

Braz J Med Biol Res

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in Ribeirão Preto, SP, Brazil. Leão and von Gersdorff (1) demonstrated the importance of Ca 2+ buffering in the developing rat calyx of Held. Garção and Mattioli (2) showed that L-histidine, a histaminergic precursor, impairs memory consolidation in Carassius auratus after cerebellar ablation. Cofiel and Mattioli (3), also using L-histamine, evaluated the role of the histaminergic system in learning and stress and showed its importance in the modulation of these responses in zebrafish. The study by Margatho et al. (4) suggested that central amygdala GABAergic mechanisms are involved in atrial natriuretic peptide and oxytocin secretion in response to blood volume expansion. Nascimento and Branco (5) suggested an interesting synergism between peripheral and spinal heme oxygenase-carbon monoxide pathways that may play an antinociceptive role. Evidence was presented by de Faria et al. (6) that activation of purinergic receptors in the brain may affect water intake in animals submitted to dehydration. Burnstock (7) reviewed the history of his discovery of purinergic transmission and the role of ATP as a cotransmitter in all nerves of the peripheral and central nervous systems. The possible involvement of purinergic mechanisms in several diseases of the central nervous system was also discussed. In the field of renal physiology, Ma et al. (8) presented a review related to the renal protective effect of the blockade of stress-activated protein kinases p38 and JNK, which may be relevant to therapeutic interventions in human renal disease. Balbi et al. (9) reviewed the interaction of mitogen-activated protein kinases and angiotensin II during renal development. With respect to calcium mechanisms, Petersen (10) presented an important review of the role of Ca 2+ signaling in pancreatic acinar cells in physiological and pathophysiological conditions. This review is an excellent example of the translational physiology from basic concepts to a human disease such as pancreatitis. Rodrigues et al. (11) presented an interesting review discussing the role of Ca 2+ signaling in the cell nucleus and Navegantes et al. (12) highlighted the mechanisms and effects of Ca 2+ -dependent protein degradation on oxidative muscles by increasing calpastatin levels and the mechanisms by which endogenous catecholamines induce anabolic muscle effects.In the cardiovascular field we have three interesting reviews. Durand et al. (13) (16) presented a review of the central effect of glucocorticoids in the control of body fluid homeostasis and the role of endocannabinoids, glutamate neurotransmission and the nuclear factor kappa B pathways. Leonelli et al. (17) discussed the new roles of neurotransmitters in development, plasticity, neurodegeneration and neuroprotection with focus on endocannabinoids and nitric oxide, which are considered to be unconventional neurotransmitters. Garcia-Cairasco (18) discussed epilepsies in the context of neurobiological models of high complexity systems displaying maladaptive plasticity. Different concepts involvi...

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GABA in the central amygdaloid nucleus modulates the electrolyte excretion and hormonal responses to blood volume expansion in rats

Cited by 5 publications

References 36 publications

Oxytocin in the Central Amygdaloid Nucleus Modulates the Neuroendocrine Responses Induced by Hypertonic Volume Expansion in the Rat

Oxytocin in the Central Amygdaloid Nucleus Modulates the Neuroendocrine Responses Induced by Hypertonic Volume Expansion in the Rat

Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis

IV Miguel R. Covian Symposium: new challenges for physiologists

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