GABA-induced changes of the tissue-specific peptide pool of white rat brain

Karelin, A. A.; Philippova, Marina M.; Karelina, E. V.; Strizhkov, Boris N.; Nazimov, Igor V.; Иванов, В. Т.; Danilova, R. A.; Ашмарин, И. П.

doi:10.1002/(sici)1099-1387(200004)6:4<168::aid-psc243>3.0.co;2-s

Cited by 4 publications

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“…• These peptides are generated by endogenous proteolytic enzymes from proteins with well established function (haemoglobin, actin, cellular enzymes). • The content and the composition of pool components correlate with the pathologies related to alterations of tissue metabolism [51][52][53][54][55]. • The in vivo function of the components of the peptide pools was suggested as the maintenance of tissue homeostasis, i.e.…”

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What to synthesize? from Emil Fischer to peptidomics

Иванов

Blishchenko

Sazonova

et al. 2003

Journal of Peptide Science

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The driving forces, incentives and strategic targets of peptide synthesis have undergone considerable evolution during the centenary following the pioneer work of Emil Fischer. In those days peptide synthesis was considered as a way of confirming the polypeptide theory of protein structure. The scientific community also expected (naively) that the synthesis would eventually lead to the creation of artificial living organisms. Only in the 1950s, when the first exact amino acid sequences were established did peptide chemistry obtain firmer ground and clearly defined targets. The total synthesis of peptide hormones and antibiotics became possible, providing valuable material for elucidating structure-functional relationships and the mechanisms of biological action. In the following years the number of peptides isolated from various biological sources grew with impressive speed and peptides became known as the most abundant, ubiquitous group of low molecular bioregulators. The design and synthesis of novel peptide based pharmaceuticals became an important area of peptide chemistry. At present we are facing the challenge of analysing the structures and bioactivities of total sets of peptides, i.e. peptidoms, present in concrete tissues or groups of cells. The results obtained along these lines at the IBCH RAS Institute of Bioorganic Chemistry are briefly considered in the review.

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confidence: 99%