Gaba

Iron oxide nanoparticles have garnered significant interest in recent years due to their diverse applications, particularly in the therapeutic field. We present a green synthesis method using the extract of Senna bicapsularis, the production of iron oxide nanoparticles (IONPs). The successful synthesis of IONPs was confirmed by UV–visible spectroscopy, revealing the characteristic peak at 295 nm. Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy were employed to elucidate the functional groups involved in the synthesis and characterize the morphological features of the nanoparticles. Subsequently, the synthesized IONPs were subjected to biological assays to assess their anticancer, enzyme inhibitory, analgesic, and sedative activities, following standardized protocols. The IONPs exhibited potent anticancer activity against the MDR 2780AD cell line, with IC50 values of 0.85 (extract) and 0.55 (iron oxide nanoparticles). Remarkable inhibitory effects were also observed against urease (IC50 = 12.98 ± 0.98) and xanthine oxidase (IC50 = 96.09 ± 0.65). Additionally, they demonstrated moderate carbonic anhydrase II inhibition, with 42.09% inhibition at a concentration of 0.25 mM. Furthermore, the extract and IONPs demonstrated a significant analgesic effect in a dose-dependent manner, while the sedative effect was also significant (p < 0.001).

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Gaba

Cited by 3 publications

References 60 publications

Modern Sedation and Analgesia Strategies in Neurocritical Care

Modern Sedation and Analgesia Strategies in Neurocritical Care

Assessment of sedative activity of Chrysin: Behavioral approach with pharmacokinetics, toxicological profile and molecular docking

Green synthesis and multifaceted characterization of iron oxide nanoparticles derived from Senna bicapsularis for enhanced in vitro and in vivo biological investigation

Contact Info

Product

Resources

About