GABA Neurons and Their Role in Activity-Dependent Plasticity of Adult Primate Visual Cortex

Jones, Edward G.; Hendry, S. H. C.; DeFelipe, Javier; Benson, D. L.

doi:10.1007/978-1-4757-9628-5_3

Cited by 30 publications

(24 citation statements)

References 217 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results confirm previous reports that the CO staining pattern of humans differs from that of most monkeys (17,(25)(26)(27)(28) and indicate that at least some apes, specifically, chimpanzees and probably also orangutans, possess a humanlike condition. The ape-human pattern is marked by the absence of the thin, dense band of CO staining within layer 4A that is typical of nonhominoids, along with darker staining of layer 4B than is seen in monkeys.…”

Section: Discussionsupporting

confidence: 92%

“…The fact that the honeycomb is so common in New World and Old World monkeys suggests it should be present in hominoid primates (apes and humans), animals that are closely related to Old World monkeys (24). It is thus surprising that published studies are unanimous in reporting that humans lack a CO-dense 4A band (17,(25)(26)(27)(28). This finding has led WongRiley et al (28) to suggest that the organization of the geniculate projection to layer 4A may have been modified in humans compared with monkeys.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Distinctive compartmental organization of human primary visual cortex

Preuss

Kaas

1999

Proc. Natl. Acad. Sci. U.S.A.

112

View full text Add to dashboard Cite

In the primary visual area of macaques and other monkeys, layer 4A is a mosaic of separate tissue compartments related to the parvocellular (P) and magnocellular (M) layers of the lateral geniculate nucleus. This mosaic resembles a honeycomb, with thin walls that receive direct P inputs and cores consisting of columns of dendrites and cell bodies ascending from layer 4B, a layer that receives indirect M inputs. To determine whether apes and humans have a macaque-like layer 4A, we examined the primary visual area in humans, chimpanzees, an orangutan, Old World monkeys, and New World monkeys. Apes and humans lacked the dense band of cytochrome oxidase staining in layer 4A that marks the stratum of P-geniculate afferents in monkeys. Furthermore, humans displayed a unique arrangement of presumed M-related cells and dendrites in layer 4A, as revealed with antibodies against nonphosphorylated neurofilaments and microtubule-associated protein 2. Human 4A contained a large amount of M-like tissue distributed in a complex, mesh-like pattern rather than in simple vertical arrays as in other anthropoid primates. Our results suggest that (i) the direct P-geniculate projection to layer 4A was reduced early in the evolution of the ape-human group, (ii) the M component of layer 4A was subsequently modified (and possibly enhanced) in the human lineage, and (iii) the honeycomb model does not adequately characterize human layer 4A. This is the first demonstration of a difference in the cortical architecture of humans and apes, the animals most closely related to humans.

show abstract

Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Distinctive compartmental organization of human primary visual cortex

Preuss

Kaas

1999

Proc. Natl. Acad. Sci. U.S.A.

112

View full text Add to dashboard Cite

show abstract

“…Double-bouquet cell axons. We found that, as has described previously in the neocortex of both monkeys and humans, double-bouquet cell axons were numerous and were distributed regularly in all cortical areas examined (for reviews, see Jones et al, 1994;DeFelipe, 1997). However, we found that the subpopulations of CB-ir and CR-ir double-bouquet cells differed in their distribution.…”

Section: Identification and Distribution Of Double-bouquet Cells And supporting

confidence: 61%

Distribution and patterns of connectivity of interneurons containing calbindin, calretinin, and parvalbumin in visual areas of the occipital and temporal lobes of the macaque monkey

et al. 1999

View full text Add to dashboard Cite

“…CR 1 cells bore all the typical hallmarks of nonpyramidal local-circuit neurons in the cortex (Jones et al, 1994) and could be subdivided into several distinct types on the Fig. 3.…”

Section: Morphology Of Cr 1 Cells In Human Mpfcmentioning

confidence: 99%

“…mata, and dendrites) of pyramidal neurons, but they also innervate other interneurons (Jones et al, 1994). Subpopulations of electrophysiologically characterised and morphologically identified local-circuit neurons can be distinguished by the presence of the calcium-binding proteins parvalbumin (PV) and calbindin D-28K (CB; Kubota, 1993, 1996).…”

mentioning

confidence: 99%

Calretinin neurons in human medial prefrontal cortex (areas 24a,b,c, 32?, and 25)

1997

View full text Add to dashboard Cite

The calcium-binding protein calretinin (CR) is present in a subpopulation of local-circuit neurons in the mammalian cerebral cortex containing gamma-aminobutyric acid. This light microscopic investigation provides a detailed qualitative and quantitative morphological analysis of CR-immunoreactive (CR+) neurons in the medial prefrontal cortex (mPFC; areas 24a,b,c, 32', and 25) of the normal adult human. The morphology of CR+ neurons and their areal and laminar distributions were consistent across human mPFC. The principal organisational features of CR+ labelling were the marked laminar distribution of immunoreactive somata and the predominantly vertical orientation of labelled axon-like and dendritic processes. Several types of CR- neurons were present in layer 1, including horizontally aligned Cajal-Retzius cells. In layers 2-6, CR+ neurons displayed a variety of morphologies: bipolar cells (49% of CR+ population), vertically bitufted cells (35%), and horizontally bitufted cells (3.5%). These neuron types were mainly located in layer 2/upper layer 3, and their dendritic processes were commonly aspiny and sometimes highly beaded. Aspiny (8%) and sparsely spiny multipolar (5%) CR+ neurons were also found. The mean somatic profile diameter of CR+ cells was 11.6 +/- 0.3 microm (mean +/- S.D). CA+ puncta formed pericellular baskets around unlabelled circular somatic profiles in layers 2/3 and around unlabelled pyramidal-shaped somata in layers 5/6. The somatic sizes of these unlabelled cell populations were significantly different. Immunolabelled puncta were also found in close contact with CR+ somata. Cortical depth distribution histograms and laminar thickness measurements defined the proportions of the overall CR- cell population in each layer: 7% in layer 1, 78% in layers 2/3, 14% in layers 5/6, and 1% in the white matter. In the tangential plane, CR+ neurons were distributed uniformly at all levels of the cortex. By using stereological counting procedures on immunoreacted Nissl-stained sections, CR+ neurons were estimated to constitute a mean 8.0% (7.2-8.7%) of the total neuron population in each cortical area. These data are compared with similar information obtained for the mPFC in monkey and rat (Gabbott and Bacon [1996b] J. Comp. Neurol. 364:657-608; Gabbott et al., [1997] J. Comp. Neurol. 377:465-499). This study provides important morphological insights into a neurochemically distinct subclass of local-circuit inhibitory neurons in the human mPFC.

show abstract

GABA Neurons and Their Role in Activity-Dependent Plasticity of Adult Primate Visual Cortex

Cited by 30 publications

References 217 publications

Distinctive compartmental organization of human primary visual cortex

Distinctive compartmental organization of human primary visual cortex

Distribution and patterns of connectivity of interneurons containing calbindin, calretinin, and parvalbumin in visual areas of the occipital and temporal lobes of the macaque monkey

Calretinin neurons in human medial prefrontal cortex (areas 24a,b,c, 32?, and 25)

Contact Info

Product

Resources

About