2008
DOI: 10.1016/j.ejphar.2008.10.013
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GABA released from cultured cortical neurons influences the modulation of t-[35S]butylbicyclophosphorothionate binding at the GABAA receptor

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Cited by 22 publications
(19 citation statements)
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“… 39 demonstrated that overexpression of endothelial NOS in the rostral ventrolateral medulla favours GABA release and sympathoinhibition, reducing sympathetic tone to the vessels and heart and causing hypotension and bradycardia. In addition to the possible monoterpene‐derived NO release, monoterpenes have been shown to directly induce GABA release in cultured cortical neurons 40 . Furthermore, postural hypotension is listed as a possible side‐effect of pine oil ingestion, 18 but there are no data regarding this effect of α‐terpineol.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“… 39 demonstrated that overexpression of endothelial NOS in the rostral ventrolateral medulla favours GABA release and sympathoinhibition, reducing sympathetic tone to the vessels and heart and causing hypotension and bradycardia. In addition to the possible monoterpene‐derived NO release, monoterpenes have been shown to directly induce GABA release in cultured cortical neurons 40 . Furthermore, postural hypotension is listed as a possible side‐effect of pine oil ingestion, 18 but there are no data regarding this effect of α‐terpineol.…”
Section: Discussionmentioning
confidence: 99%
“…In addition to the possible monoterpene-derived NO release, monoterpenes have been shown to directly induce GABA release in cultured cortical neurons. 40 Furthermore, postural hypotension is listed as a possible sideeffect of pine oil ingestion, 18 but there are no data regarding this effect of a-terpineol. These possibilities are matters for further investigation.…”
Section: Discussionmentioning
confidence: 99%
“…The latter are products that add beneficial properties to the health of those who consume them without having a nutritious value or being included in the vitamin group (Zygadlo and Juliani, 2000). Some essential oils (EO) and their main components may be considered functional foods because of their properties such as modulators of gamma-aminobutyric acid activity and fear reducers (antistress; Perillo et al, 1999;García et al, 2008;Lábaque et al, 2013), antioxidants (Botsoglou et al, 2002;Luna et al, 2010), anti-cholesterolemics (Crowell, 1999), antimicrobians (Lambert et al, 2001), and antifungical (Adam et al, 1998), among others. The bioactivities of the EO mainly depend on their components, which may vary even within the same plant species (Zygadlo and Juliani, 2000).…”
Section: Introductionmentioning
confidence: 99%
“…The affinities and efficacies of dFBr were altered by Tris and HEPES buffers. A previous study comparing Tris and HEPES buffers showed that the gamma aminobutyric acid type A receptor (GABA A receptor) PAM, thymol, displayed biphasic behavior in a HEPES buffer while only inhibition was seen when using a Tris buffer (Garcia et al, 2008). Similarly in our laboratory, dFBr appears to be more efficacious for the HS versus LS α4β2 receptors when using a HEPES buffer.…”
Section: Discussionmentioning
confidence: 99%