GABA_BEncephalitis: A Fifty-Two-Year-Old Man with Seizures, Dysautonomia, and Acute Heart Failure

Abstract

Autoantibodies to the γ-aminobutyric acid receptor, subtype B (GABAB), are a known cause of limbic encephalitis. The spectrum of clinical manifestations attributable to this antibody is not well defined at the present time. Here we present a case of GABAB encephalitis presenting with encephalopathy, status epilepticus, dysautonomia, and acute heart failure. To our knowledge, heart failure and dysautonomia have not yet been reported with this syndrome.

Clinical characteristics and prognostic analysis of anti-gamma-aminobutyric acid-B (GABA-B) receptor encephalitis in Northeast China

“…As previously reported, LE can lead to autonomic dysfunction via the connection between the medial temporal lobe and insular cortex [16, 17]. Loftspring et al , reported a case of anti-GABA-B receptor encephalitis with cardiac autonomic dysfunction [18]. However, gastrointestinal autonomic dysfunction has not yet been reported in patients with anti-GABA-B receptor encephalitis.…”