GABAA- and GABAB-receptor-mediated modification of intestinal motility

Ong, Jennifer; Kerr, Donald

doi:10.1016/0014-2999(82)90390-9

Cited by 167 publications

(66 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the circular muscle of cat colon GABAA-receptor stimulation causes excitatory cholinergic responses (Taniyama et al, 1987). In the guinea-pig, activation of colonic GABAA-receptors induces non-adrenergic noncholinergic (NANC) inhibitory responses (Krantis et al, 1980;Onori et al, 1984), while GABAB-receptors are associated with a consistent decrease of the basal cholinergic tone supplying the longitudinal muscle layer (Giotti et al, 1985) and the cholinergic rhythmic contractions of the circular coat (Ong & Kerr, 1983). Studies designed to evaluate the possible functional role of GABA-containing neurones on the propulsive activity of guinea-pig colon by using GABAA-receptor antagonists and desensitization procedures have given conflicting results.…”

Section: Introductionmentioning

confidence: 99%

An in vitro study of the relationship between GABA receptor function and propulsive motility in the distal colon of the rabbit

Tonini

Crema

Frigo

et al. 1989

British J Pharmacology

View full text Add to dashboard Cite

1 The effects of y-aminobutyric acid (GABA), 3-aminopropane sulphonic acid (3-APS) and baclofen on spontaneous, electrically-induced and propulsive motility were investigated in rabbit distal colon. dependently decreased the velocity of propulsion of an intraluminally-distended balloon. This effect was antagonized by DAVA and GABA or baclofen desensitization and resistant to SR 95531 and picrotoxinin. These antagonists per se had no effect on propulsion. In preparations in which propulsion was slowed by hyoscine (1 yM), baclofen caused no consistent further depression of propulsive activity.5 Our results show that GABAA-and GABAB-receptors are present in rabbit colon. GABAA-receptor stimulation activates NANC inhibitory nerves without apparently affecting propulsion. GABAB-receptors are associated with a reduction of neural (mainly cholinergic) activity subserving muscular tone and peristalsis and appear to be located on both cholinergic and NANC inhibitory nerves. However, the persisting propulsive activity during suppression of GABAA-and GABAB-receptor function suggests that GABA in enteric neurones is not crucial for the neural circuitry subserving colonic peristalsis in this species.

show abstract

Section: Introductionmentioning

confidence: 99%

An in vitro study of the relationship between GABA receptor function and propulsive motility in the distal colon of the rabbit

Tonini

Crema

Frigo

et al. 1989

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…Ong and Kerr (1982) observed that GABA-A and GABA-B receptors had different responses to type of GABA or their receptor agonists. In the current study, the GABA-B receptor in the duodenum seemed to be more sensitive to dietary GABA than GABA-A receptor did.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, motility in duodenum can be inhibited by activating GABA-A receptor, or be activated by stimulating GABA-B receptor (Fargeas et al, 1988). In contrast, motility in ileum can be activated by stimulating GABA-A receptor, or be restrained by activation of GABA-B receptor (Ong and Kerr, 1982). The reduced motility of gastrointestinal tracts may cause inhibited digestion and lower DMI (Xing and Chen, 2004).…”

Section: Introductionmentioning

confidence: 99%

Effects of γ-aminobutyric acid on feed intake, growth performance and expression of related genes in growing lambs

Wang

Chacher

Liu

et al. 2015

Animal

View full text Add to dashboard Cite

This study was conducted to investigate the effects of rumen-protected γ-aminobutyric acid (GABA) on feed intake, growth performance and expression of related genes in growing lambs. A total of 24 lambs weaned at age of 50 days were divided into four block of six based on their BW, six lambs within a block were allocated to three pairs, which were then assigned randomly to three treatments with addition of rumen-protected GABA at levels of 0, 70 or 140 mg/day for 6 weeks. Dry matter intake was recorded weekly in three consecutive days, and BW was recorded every two weeks. At the end of the trial, four lambs from each group were slaughtered, and duodenum and ileum mucosa were obtained for measurement of mRNA abundance of GABA receptor and cholecystokinin receptor. Dry matter intake was higher ( P < 0.01) in the lambs fed 140 mg/day GABA than that in the control or 70 mg GABA-fed lambs. Average daily gain and nutrients digestibility were not different ( P > 0.05) among treatments. Lambs fed 140 mg/day GABA had higher mRNA abundance of GABA-B receptor ( P < 0.01) and lower mRNA abundance of cholecystokinin-2 receptor ( P < 0.01) in duodenum mucosa. Serum CCK content was lower ( P < 0.01) in lambs fed 140 mg/day GABA than that in control. It is indicated that GABA may enhance feed intake by regulating GABA-and cholecystokininrelated genes.

show abstract

“…Since the proposal that y-aminobutyric acid (GABA) may be a neurotransmitter in the vertebrate peripheral nervous system (Jessen et al, 1979), evidence has accumulated demonstrating the presence of GABA receptors in the gastrointestinal tract (Krantis et al, 1980;Giotti et al, 1983;Ong & Kerr, 1983;Maggi et al, 1984). By use of selective agonists and antagonists Giotti et al, 1983), two subclasses of GABA receptors can be distinguished: GABAA receptors, stimulated by GABA, homotaurine (3-amino-1-propane sulphonic acid) or muscimol and inhibited by bicuculline (competitively) and picrotoxin (non-competitively).…”

Section: Introductionmentioning

confidence: 99%

“…Several lines of evidence suggest that GABA affects the motility of intestinal preparations mainly by altering the release of acetylcholine from intrinsic cholinergic neurones; stimulation of GABAA receptors may increase acetylcholine output (Krantis et al, 1980;Giotti et al, 1983;Ong & Kerr, 1983) whereas GABAB receptor stimulation may inhibit acetylcholine release (Ong & Kerr, 1983;Giotti et al, 1983;. In addition, evidence is available to suggest that GABA stimulates inhibitory intramural non-adrenergic noncholinergic (NANC) neurones in the rat duodenum (Maggi et al, 1984), and in the guinea-pig and rabbit distal colon (Krantis et al, 1980;Giotti et al, 1985, Tonini et al, 1989.…”

Section: Introductionmentioning

confidence: 99%

GABA_A receptor‐mediated stimulation of non‐adrenergic non‐cholinergic neurones in the dog ileocolonic junction

Boeckxstaens

Pelckmans

Rampart

et al. 1990

British J Pharmacology

View full text Add to dashboard Cite

1 The inhibitory effects of y-aminobutyric acid (GABA), the GABAA receptor agonist homotaurine and the GABAB receptor agonist (± )-baclofen were investigated on circular muscle strips of the dog terminal ileum and ileocolonic junction. 2 In the presence of atropine, GABA and homotaurine induced concentration-dependent relaxations, similar to the non-adrenergic non-cholinergic (NANC-mediated relaxations evoked by electrical stimulation or by acetylcholine. The ileocolonic junction was more sensitive to GABA and homotaurine than the ileum. (+)-Baclofen had no effect. Cross desensitization only occurred between GABA and homotaurine. 3 The GABAA receptor antagonist bicuculline shifted the concentration-response curves to GABA and homotaurine to the right. The maximal relaxation to GABA remained unaffected. 4 GABA-induced relaxations were not inhibited by timolol, guanethidine, domperidone, hexamethonium and desensitization to ATP, but were abolished by tetrodotoxin. 5Bicuculline, and pretreatment with GABA or ( )-baclofen had no effect on the NANC-evoked relaxations to electrical stimulation and acetylcholine. 6 In conclusion, GABA stimulates GABAA receptors located on inhibitory NANC neurones in the dog ileocolonic junction. Our results suggest that it is unlikely that GABA is the final inhibitory NANC neurotransmitter.

show abstract

GABAA- and GABAB-receptor-mediated modification of intestinal motility

Cited by 167 publications

References 26 publications

An in vitro study of the relationship between GABA receptor function and propulsive motility in the distal colon of the rabbit

An in vitro study of the relationship between GABA receptor function and propulsive motility in the distal colon of the rabbit

Effects of γ-aminobutyric acid on feed intake, growth performance and expression of related genes in growing lambs

GABA_A receptor‐mediated stimulation of non‐adrenergic non‐cholinergic neurones in the dog ileocolonic junction

Contact Info

Product

Resources

About

GABAA- and GABAB-receptor-mediated modification of intestinal motility

Cited by 167 publications

References 26 publications

An in vitro study of the relationship between GABA receptor function and propulsive motility in the distal colon of the rabbit

An in vitro study of the relationship between GABA receptor function and propulsive motility in the distal colon of the rabbit

Effects of γ-aminobutyric acid on feed intake, growth performance and expression of related genes in growing lambs

GABAA receptor‐mediated stimulation of non‐adrenergic non‐cholinergic neurones in the dog ileocolonic junction

Contact Info

Product

Resources

About

GABA_A receptor‐mediated stimulation of non‐adrenergic non‐cholinergic neurones in the dog ileocolonic junction