GABAB Receptors and Alcohol Use Disorders: Clinical Studies

Logge, Warren; Morley, Kirsten C.; Haber, Paul

doi:10.1007/7854_2020_182

Cited by 10 publications

(2 citation statements)

References 70 publications

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“…We examined the molecular profiles of the network markers, and the results highlighted the role of the GABAergic and serotonergic signaling in alcohol use severity. This finding is consistent with a large body of clinical and preclinical research implicating the GABAergic and serotonergic systems in alcohol misuse [ 49 , 50 , 51 , 52 ].…”

Section: Discussionsupporting

confidence: 89%

Functional Networks of Reward and Punishment Processing and Their Molecular Profiles Predicting the Severity of Young Adult Drinking

Li,

Yang,

Hao

et al. 2024

Brain Sciences

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Alcohol misuse is associated with altered punishment and reward processing. Here, we investigated neural network responses to reward and punishment and the molecular profiles of the connectivity features predicting alcohol use severity in young adults. We curated the Human Connectome Project data and employed connectome-based predictive modeling (CPM) to examine how functional connectivity (FC) features during wins and losses are associated with alcohol use severity, quantified by Semi-Structured Assessment for the Genetics of Alcoholism, in 981 young adults. We combined the CPM findings and the JuSpace toolbox to characterize the molecular profiles of the network connectivity features of alcohol use severity. The connectomics predicting alcohol use severity appeared specific, comprising less than 0.12% of all features, including medial frontal, motor/sensory, and cerebellum/brainstem networks during punishment processing and medial frontal, fronto-parietal, and motor/sensory networks during reward processing. Spatial correlation analyses showed that these networks were associated predominantly with serotonergic and GABAa signaling. To conclude, a distinct pattern of network connectivity predicted alcohol use severity in young adult drinkers. These “neural fingerprints” elucidate how alcohol misuse impacts the brain and provide evidence of new targets for future intervention.

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Section: Discussionsupporting

confidence: 89%

Functional Networks of Reward and Punishment Processing and Their Molecular Profiles Predicting the Severity of Young Adult Drinking

Li,

Yang,

Hao

et al. 2024

Brain Sciences

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 88%

Functional networks of reward and punishment processing and their molecular profiles predicting the severity of young adult drinking

Li,

Yang,

Hao

et al. 2024

Preprint

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BackgroundAlcohol misuse is associated with altered punishment and reward processing. Here, we investigated neural network responses to reward and punishment and the molecular profiles of the connectivity features predicting alcohol use severity in young adults.MethodsWe curated the Human Connectome Project data and employed connectome-based predictive modeling (CPM) to examine how functional connectivity (FC) features during wins and losses associated with alcohol use severity in 981 young adults. Alcohol use severity was quantified by the first principal component of principal component analysis of all drinking measures of the Semi-Structured Assessment for the Genetics of Alcoholism. We combined the CPM findings and JuSpace toolbox to characterize the molecular profiles of the network connectivity features of alcohol use severity.ResultsThe connectomics predicting alcohol use severity appeared specific, comprising less than 0.12% of all connectivity features. These connectivities featured the medial frontal, motor/sensory, and cerebellum/brainstem networks during punishment processing and medial frontal, fronto-parietal, and motor/sensory networks during reward processing. Spatial correlation analyses showed that these networks were associated predominantly with serotonergic and GABAa signaling.ConclusionsA distinct pattern of network connectivity predicted alcohol use severity in young adult drinkers. These network features were associated with the serotonergic and GABAa signaling. These “neural fingerprints” help in elucidating the impact of alcohol misuse on the brain and providing evidence of new targets for future intervention.

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