GABAergic excitation in striatal projection neurons: Simulations and experiments

Ayling, Martin; Panzeri, Stefano; Bracci, Enrico

doi:10.1016/j.neucom.2006.10.125

Cited by 2 publications

(3 citation statements)

References 22 publications

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“…Another experimental observation by Wilson (1993) is that highly irregular firing predominates, (Ponzi and Wickens, 2013). Though in the work of Ayling et al (2007), it is argued that GABAergic post-synaptic potentials can exert excitatory effects on projection neurons, here we considered the conventional approach of inhibitory behavior in striatum.…”

Section: Network Structure Of Striatal Medium Spiny Neuronsmentioning

confidence: 99%

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Modeling dynamic behavior of striatal medium spiny neurons with point neuron models

2018

Tamap J. Eng.

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The aim of this work is to investigate the role of network organization and the neuron model type on the collective dynamic behavior of striatal population. For that purpose, two different scale neuron models which are phenomenological Izhikevich and conductance-based Hodgkin-Huxley (HH) type are used to investigate the dynamic behavior of MS neurons. Two network architectures are proposed with inhibitory and excitatory synaptic currents. In these networks, while all MS neurons affect each other with inhibitory synaptic currents, an excitatory current is applied to all MS neurons in the first layer, to represent the cortical inputs. A mathematical model of a medium spiny neuron of striatum based on HH type neuron model is proposed using different calcium channels and its dynamical behavior is investigated. It is observed that when the original HH model is used, regular spiking type behavior is observed. Including the high threshold calcium current, after hyperpolarization calcium current and voltage gated potasium current into the model improves the modeling capabilities. With extended ion channels, in addition to regular spiking behavior, bursting with resting stage are obtained. Then, Izhikevich neuron model is used in the network structures to compare the dynamic behaviors and computational time.

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Section: Network Structure Of Striatal Medium Spiny Neuronsmentioning

confidence: 99%

“…As the striatum is the main gateway to the basal ganglia, it activates a group of interconnected subcortical nuclei that are crucial for motor planning, (Kim et al 2013;Ayling et al 2007). Therefore, modeling of dynamic behavior of striatum is an important component of work on Parkinson's disease.…”

Section: Introductionmentioning

confidence: 99%

Modeling dynamic behavior of striatal medium spiny neurons with point neuron models

2018

Tamap J. Eng.

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“…Even though the number of work focuses on computational modeling of neural structures such as basal ganglia, cortex, thalamus and striatum are high, the modeling of dynamic behaviors is still a debate subject in the literature due to the complexity of these structures [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. In computational neuroscience, modeling the behaviors of neural system is an important issue in order to investigate the mechanisms underlying for neurological disorders and diseases such as Parkinson's and Huntington Disease.…”

Section: Introductionmentioning

confidence: 99%

Comparision of Dynamic Behaviors of Striatal Population With Two Different Neuron Models: Hodgkin-Huxley and Izhikevich

Cakir¹

2016

deufmd

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In computational neuroscience, using the tools of dynamical systems theory and modeling the behaviors of neural system is an important issue in order to investigate the mechanisms underlying for neurological disorders and diseases such as Parkinson's and Huntington Disease. In this work, the dynamic behavior of striatal population is investigated using two different scale neuron models: Izhikevich neuron model and Hodgkin-Huxley type model. In the modeling, the influences of network organization are investigated as well. Two different network architectures are used. For all these investigations in-house built MATLAB codes are used. It is shown that Izhikevich neuron model can be used to model the dynamic behavior of striatal neuron populations, with a much simplier representation than conductance-based HH neurons.

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GABAergic excitation in striatal projection neurons: Simulations and experiments

Cited by 2 publications

References 22 publications

Modeling dynamic behavior of striatal medium spiny neurons with point neuron models

Modeling dynamic behavior of striatal medium spiny neurons with point neuron models

Comparision of Dynamic Behaviors of Striatal Population With Two Different Neuron Models: Hodgkin-Huxley and Izhikevich

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