GABAergic inhibition gates excitatory LTP in perirhinal cortex

Kotak, Vibhakar C.; Mirallave, Ana; Mowery, Todd M.; Sanes, Dan H.

doi:10.1002/hipo.22799

Cited by 17 publications

(17 citation statements)

References 54 publications

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“…These results are in line with ours reporting alterations of neural plasticity in the motor cortex in patients with MDD. These observations are also consistent with animal studies reporting that the iTBS-induced LTP mechanisms could be modulated by the administration of GABA antagonists (Kotak et al, 2017).…”

Section: Discussionsupporting

confidence: 91%

Impaired Modulation of Corticospinal Excitability in Drug-Free Patients With Major Depressive Disorder: A Theta-Burst Stimulation Study

Vignaud

Damasceno

Poulet

2019

Front. Hum. Neurosci.

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Impaired neural plasticity may be an important mechanism in the pathophysiology of major depressive disorder (MDD). Coupled with electromyography (EMG), repetitive transcranial magnetic stimulation (rTMS) is a useful tool to evaluate corticospinal excitability and cortical neuroplasticity in living humans. The goal of this study was to compare rTMS-induced cortical plasticity changes in patients with MDD and in healthy volunteers. In this single-blind controlled study, 11 drug-free patients with MDD and 11 matched healthy controls were analyzed. Cortical excitability, measured by the amplitude of motor evoked potentials (MEPs) evoked by single-pulse TMS, was assessed before and repeatedly after (for 30 min) participants received a single session of intermittent theta-burst stimulation (iTBS) and continuous TBS (cTBS). rTMS was applied over the left motor cortex using a neuronavigation system. Intensity was set at 80% of the active motor threshold (AMT). A large interindividual variability was observed after both iTBS and cTBS in the two groups. At the group level, we observed impaired iTBS-induced neuroplasticity in patients with MDD compared to that in controls. No differences were observed between the groups regarding cTBS-induced neuroplasticity. Our results suggest impaired long-term potentiation (LTP)-like mechanisms in MDD. Clinical Trial Registration : www.Clinicaltrials.gov , identifier #NCT02438163.

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Section: Discussionsupporting

confidence: 91%

Impaired Modulation of Corticospinal Excitability in Drug-Free Patients With Major Depressive Disorder: A Theta-Burst Stimulation Study

Vignaud

Damasceno

Poulet

2019

Front. Hum. Neurosci.

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“…However, Kotak, Mirallave, Mowery, and Sanes (2017) (Nishiyama et al, 2010). In summary, animal studies have provided evidence that LTP induction depends on blocking GABAergic inhibition via the GABA receptors (Grover & Yan, 1999;Kotak et al, 2017;Liu et al, 2014;Staubli et al, 1999;Steward et al, 1990) and that of LTD may also depend on modulation of GABA interneuronal activities (Kotak et al, 2017;Nishiyama et al, 2010). .…”

Section: Glutamatergic and Gabaergic Neurotransmissions And Tbs Effmentioning

confidence: 99%

“…The presynaptic changes in GABA release are involved in the TBS-induced potentiation of synaptic plasticity (Larson & Munkacsy, 2015). In fact, several animal studies have indicated that the blockade of GABAergic inhibition (e.g., via the GABA-A receptor or GABA-B receptor) plays a key role in LTP induction (Grover & Yan, 1999;Kotak, Mirallave, Mowery, & Sanes, 2017;Liu et al, 2014;Staubli, Scafidi, & Chun, 1999;Steward, Tomasulo, & Levy, 1990). This disinhibitory process involves presynaptic GABA autoreceptors that inhibit GABA release.…”

Section: Glutamatergic and Gabaergic Neurotransmissions And Tbs Effmentioning

confidence: 99%

“…In a detailed review, Larson and Munkacsy (2015) indicated that a single burst is insufficient for LTP induction, but bursts repeated at the theta frequency induce maximal LTP, primarily because this frequency disables feedforward inhibition and allows sufficient postsynaptic depolarization. For example, when GABA-A receptor and GABA-B receptor were both blocked, LTP in the perirhinal cortical neurons was reliably induced in rats through iTBS (Kotak et al, 2017). In fact, several animal studies have indicated that the blockade of GABAergic inhibition (e.g., via the GABA-A receptor or GABA-B receptor) plays a key role in LTP induction (Grover & Yan, 1999;Kotak, Mirallave, Mowery, & Sanes, 2017;Liu et al, 2014;Staubli, Scafidi, & Chun, 1999;Steward, Tomasulo, & Levy, 1990).…”

Section: Glutamatergic and Gabaergic Neurotransmissions And Tbs Effmentioning

confidence: 99%

“…In fact, several animal studies have indicated that the blockade of GABAergic inhibition (e.g., via the GABA-A receptor or GABA-B receptor) plays a key role in LTP induction (Grover & Yan, 1999;Kotak, Mirallave, Mowery, & Sanes, 2017;Liu et al, 2014;Staubli, Scafidi, & Chun, 1999;Steward, Tomasulo, & Levy, 1990). However, Kotak, Mirallave, Mowery, and Sanes (2017) (Grover & Yan, 1999;Kotak et al, 2017;Liu et al, 2014;Staubli et al, 1999;Steward et al, 1990) and that of LTD may also depend on modulation of GABA interneuronal activities (Kotak et al, 2017;Nishiyama et al, 2010). In addition, in brain circuits where strong inhibition occurs along with excitation (e.g., the dentate commissural pathway of the hippocampus), LTP is not expressed during high-frequency electrical stimulation (Steward et al, 1990).…”

Section: Glutamatergic and Gabaergic Neurotransmissions And Tbs Effmentioning

confidence: 99%

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Critical role of glutamatergic and GABAergic neurotransmission in the central mechanisms of theta‐burst stimulation

Huang

Bai

et al. 2019

Human Brain Mapping

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Theta‐burst stimulation (TBS) is a varied form of repetitive transcranial magnetic stimulation (rTMS) and has more rapid and powerful effects than rTMS. Experiments on the human motor cortex have demonstrated that intermittent TBS has facilitatory effects, whereas continuous TBS has inhibitory effects. Huang's simplified model provides a solid basis for elucidating such after‐effects. However, evidence increasingly indicates that not all after‐effects of TBS are as expected, and high variability among individuals has been observed. Studies have suggested that the GABAergic and glutamatergic neurotransmission play a vital role in the aforementioned after‐effects, which might explain the interindividual differences in these after‐effects. Herein, we reviewed the latest findings on TBS from animal and human experiments on glutamatergic and GABAergic neurotransmissions in response to TBS. Furthermore, an updated theoretical model integrating glutamatergic and GABAergic neurotransmissions is proposed.

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Organization of orbitofrontal‐auditory pathways in the Mongolian gerbil

Ying

Hamlette

Nikoobakht

et al. 2023

J of Comparative Neurology

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Sound perception is highly malleable, rapidly adjusting to the acoustic environment and behavioral demands. This flexibility is the result of ongoing changes in auditory cortical activity driven by fluctuations in attention, arousal, or prior expectations. Recent work suggests that the orbitofrontal cortex (OFC) may mediate some of these rapid changes, but the anatomical connections between the OFC and the auditory system are not well characterized. Here, we used virally mediated fluorescent tracers to map the projection from OFC to the auditory midbrain, thalamus, and cortex in a classic animal model for auditory research, the Mongolian gerbil (Meriones unguiculatus). We observed no connectivity between the OFC and the auditory midbrain, and an extremely sparse connection between the dorsolateral OFC and higher order auditory thalamic regions. In contrast, we observed a robust connection between the ventral and medial subdivisions of the OFC and the auditory cortex, with a clear bias for secondary auditory cortical regions. OFC axon terminals were found in all auditory cortical lamina but were significantly more concentrated in the infragranular layers. Tissue‐clearing and lightsheet microscopy further revealed that auditory cortical‐projecting OFC neurons send extensive axon collaterals throughout the brain, targeting both sensory and non‐sensory regions involved in learning, decision‐making, and memory. These findings provide a more detailed map of orbitofrontal‐auditory connections and shed light on the possible role of the OFC in supporting auditory cognition.

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GABAergic inhibition gates excitatory LTP in perirhinal cortex

Cited by 17 publications

References 54 publications

Impaired Modulation of Corticospinal Excitability in Drug-Free Patients With Major Depressive Disorder: A Theta-Burst Stimulation Study

Impaired Modulation of Corticospinal Excitability in Drug-Free Patients With Major Depressive Disorder: A Theta-Burst Stimulation Study

Critical role of glutamatergic and GABAergic neurotransmission in the central mechanisms of theta‐burst stimulation

Organization of orbitofrontal‐auditory pathways in the Mongolian gerbil

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