1978
DOI: 10.1038/274383a0
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GABAergic modulation of benzodiazepine binding site sensitivity

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Cited by 720 publications
(161 citation statements)
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“…These findings could be explained by muscimol increasing the affinity of benzodiazepines for their specific receptor and thus potentiating their effects. A similar interaction has been demonstrated in vitro (Tallman, Thomas & Gallager, 1978).…”
Section: N-12-[[[5-(dimethylaminomethyl-2-furanyl] Methyl]-thio]ethylsupporting
confidence: 53%
“…These findings could be explained by muscimol increasing the affinity of benzodiazepines for their specific receptor and thus potentiating their effects. A similar interaction has been demonstrated in vitro (Tallman, Thomas & Gallager, 1978).…”
Section: N-12-[[[5-(dimethylaminomethyl-2-furanyl] Methyl]-thio]ethylsupporting
confidence: 53%
“…We have tested the ability of benzodiazepines and of GABA, which has been reported to interact with the benzodiazepine receptor [3,6], to protect against the TNM effect (table 1) TNM may also modify cysteine or, though less likely, tryptophan residues [7]. Nitration of tyrosine is expected to proceed much slower at pH 6.5 than at pH 8.0, whereas nitration of cysteine is efficient at the lower pH [4,7].…”
Section: Methodsmentioning
confidence: 99%
“…For example, the pharmacological characteristics of GABA receptors associated with pre-and postsynaptic Cl-conductance mechanisms may differ from those mediating enhancement of the binding of benzodiazepines to their receptors (Tallman, Thomas & Gallager, 1978;Karobath, Placheta, Lippitsch & Krogsgaard-Larsen, 1979;Braestrup, Nielsen, Krogsgaard-Larsen & Falch, 1979). They may also differ from autoreceptors thought to be 'Present address: Department of Pharmacology, School of Pharmacy, 29-39 Brunswick Square, London WC 1. 0007-1188/83/010191-16-$01.00 present within the mammalian brain (Mitchell & Martin, 1978;Snodgrass, 1978;Brennan & Cantrill, 1979).…”
Section: Introductionmentioning
confidence: 99%