GABAergic regulation of spontaneous spike patterns in the developing rabbit retina

Zhou, Elton; Xu, Hòng

doi:10.1016/j.neulet.2015.06.003

Cited by 2 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18,30 Glu and GABA, the major excitatory and inhibitory neurotransmitters in retina and other parts of the central nervous system, 31,32 also were closely related to the neural development, which is associated with the visual system in the rabbit, chick, and rat eye. [33][34][35] On one hand, studies found that the Glu and its receptor were associated with the excitatory synaptic development and the circulation of the retinotectal system, 1,3 and the excitotoxicity induced by Glu could lead to the abnormal development of the retina and the occurrence of diseases, such as retinal ischemia, neuronal necrosis, and glaucoma. [36][37][38] On the other hand, studies also found that GABA would affect the growth and development of retinal neurons in culture, and its agonist baclofen may stimulate the visual system developing of Xenopus laevis and the retinal ganglion cell axons extent.…”

Section: Neurotransmitter and Visual Developmentmentioning

confidence: 99%

Alterations of Glutamate and γ-Aminobutyric Acid Expressions in Normal and Myopic Eye Development in Guinea Pigs

Xiang

et al. 2017

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

Section: Neurotransmitter and Visual Developmentmentioning

confidence: 99%

Alterations of Glutamate and γ-Aminobutyric Acid Expressions in Normal and Myopic Eye Development in Guinea Pigs

Xiang

et al. 2017

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

Retinal Wave Patterns Are Governed by Mutual Excitation among Starburst Amacrine Cells and Drive the Refinement and Maintenance of Visual Circuits

Xu¹,

Burbridge²,

et al. 2016

J. Neurosci.

Self Cite

View full text Add to dashboard Cite

Retinal waves are correlated bursts of spontaneous activity whose spatiotemporal patterns are critical for early activity-dependent circuit elaboration and refinement in the mammalian visual system. Three separate developmental wave epochs or stages have been described, but the mechanism(s) of pattern generation of each and their distinct roles in visual circuit development remain incompletely understood. We used neuroanatomical, in vitro and in vivo electrophysiological, and optical imaging techniques in genetically manipulated mice to examine the mechanisms of wave initiation and propagation and the role of wave patterns in visual circuit development. Through deletion of ␤2 subunits of nicotinic acetylcholine receptors (␤2-nAChRs) selectively from starburst amacrine cells (SACs), we show that mutual excitation among SACs is critical for Stage II (cholinergic) retinal wave propagation, supporting models of wave initiation and pattern generation from within a single retinal cell type. We also demonstrate that ␤2-nAChRs in SACs, and normal wave patterns, are necessary for eye-specific segregation. Finally, we show that Stage III (glutamatergic) retinal waves are not themselves necessary for normal eye-specific segregation, but elimination of both Stage II and Stage III retinal waves dramatically disrupts eye-specific segregation. This suggests that persistent Stage II retinal waves can adequately compensate for Stage III retinal wave loss during the development and refinement of eye-specific segregation. These experiments confirm key features of the "recurrent network" model for retinal wave propagation and clarify the roles of Stage II and Stage III retinal wave patterns in visual circuit development.

show abstract

GABAergic regulation of spontaneous spike patterns in the developing rabbit retina

Cited by 2 publications

References 26 publications

Alterations of Glutamate and γ-Aminobutyric Acid Expressions in Normal and Myopic Eye Development in Guinea Pigs

Alterations of Glutamate and γ-Aminobutyric Acid Expressions in Normal and Myopic Eye Development in Guinea Pigs

Retinal Wave Patterns Are Governed by Mutual Excitation among Starburst Amacrine Cells and Drive the Refinement and Maintenance of Visual Circuits

Contact Info

Product

Resources

About