GABAergic Stimulation Regulates the Phenotype of Hippocampal Interneurons through the Regulation of Brain-Derived Neurotrophic Factor

Marty, Serge; Berninger, Benedikt; Carroll, Patrick; Thoenen, H.

doi:10.1016/s0896-6273(00)80075-6

Cited by 239 publications

(175 citation statements)

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“…Finally, evidence from [ 3 H]-thymidine studies suggests that GABAergic horizontal cells might account for the apparent ability of GABA to help maintain the normal position of cone cell bodies and regulate cone synaptogenesis . In cultured hippocampal neurons, it was shown that GABA by acting on voltage gated calcium channels affects the expression of BDNF during a restricted period of the development, and this supports the hypothesis that GABA might have neurotrophic effects on embryonic or perinatal neurons (Berninger et al 1995;Marty et al 1996).…”

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confidence: 58%

The expression of GABA_Areceptors during the development of the rabbit retina

Mei

Bruun

Ehinger

1998

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: Gamma-amino butyric acid (GABA) is a major inhibitory neurotransmitter in the retina, possibly participating in its normal development. The distribution of gamma-aminobutyric acid receptors was therefore examined in mature and developing rabbit retina by GABA A receptor alpha 1 and beta 2/3 subunit immunocytochemistry. Results: Beta 2/3 subunits appeared already at the E25 stage (25 days after gestation) although only weakly and irregularly. Alpha 1 subunit immunoreactivity was first observed at birth. On the fifth postnatal day, immunostaining was clearly seen in the inner plexiform layer, and weaker, in the outer plexiform layer. There were at this stage no well-delineated sublayers in either the inner or the outer plexiform layer, but three clearly defined sublayers appeared in the inner plexiform layer at PN10. Amacrine cell bodies now also appeared, labelling for both the GABA A receptor alpha 1 and the beta 2/3 chains. A punctuate labelling appeared in the outer plexiform layer. From the 20th postnatal day, the immunoreactivity was similar to that seen in adult rabbits. Conclusions: Like in the adult, the alpha 1 and beta 2/3 subunits of the GABA A receptor thus colocalize predominantly in certain amacrine cells and in processes of the inner plexiform layer during the development of the retina. The GABA A receptors appear later than GABA during the development of the rabbit retina, and functioning GABA neurotransmitter circuits appear to be assembled primarily after the 3rd to 5th postnatal day. Our results support the hypothesis that GABA may have other functions than mediating classic synaptic neurotransmission before the formation of receptors containing the alpha 1 and beta 2/3 subunits. Like in the brain, the alpha subunits may have more selective functions during the development than the beta subunits.

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mentioning

confidence: 58%

The expression of GABA_Areceptors during the development of the rabbit retina

Mei

Bruun

Ehinger

1998

Acta Ophthalmologica Scandinavica

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“…The number of GABAergic interneurons was reduced in the somatosensory and visual cortices after sensory deprivation Jones, 1986, 1988;Benevento et al, 1995). Similarly, the number of GABAergic interneurons was decreased in cortical and hippocampal cultures after activity blockade with tetrodotoxin (Marty et al, 1996;Rutherford et al, 1997).…”

Section: Activity-dependent Scaling Of Gabaergic Synapse Strengthmentioning

confidence: 98%

Activity-dependent scaling of GABAergic synapse strength is regulated by brain-derived neurotrophic factor

Swanwick

Murthy

Kapur

2006

Molecular and Cellular Neuroscience

100

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The homeostatic plasticity hypothesis suggests that neuronal activity scales synaptic strength. This study analyzed effects of activity deprivation on GABAergic synapses in cultured hippocampal neurons using patch clamp electrophysiology to record mIPSCs and immunocytochemistry to visualize presynaptic GAD-65 and the γ2 subunit of the GABA A receptor. When neural activity was blocked for 48 h with tetrodotoxin (TTX, 1 μM), the amplitude of mIPSCs was reduced, corresponding with diminished sizes of GAD-65 puncta and γ2 clusters. Treatment with the NMDA receptor antagonist APV (50 μM) or the AMPA receptor antagonist DNQX (20 μM) mimicked these effects, and co-application of brain-derived neurotrophic factor (BDNF, 100 ng/mL) overcame them. Moreover, when neurons were treated with BDNF alone for 48 h, these effects were reversed via the TrkB receptor. Overall, these results suggest that activity-dependent scaling of inhibitory synaptic strength can be modulated by BDNF/TrkB-mediated signaling.

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“…Finally, and of interest for the field of schizophrenia research, hippocampal interneurons have been shown to regulate the differentiation of hippocampal neurons during development (Marty et al 1996). That many of these functions might involve functional (and presumably structural) neuroplasticity is strongly suggested by the observation that GABA, GAD, and the GABA A receptors are all regulated in an activitydependent manner (Jones 1990(Jones , 1993.…”

Section: Functions Of Gabaergic Interneurons In the Cortex And In Thementioning

confidence: 99%

GABAergic Interneurons Implications for Understanding Schizophrenia and Bipolar Disorder

Beneš

Berretta

2001

Neuropsychopharmacology

997

643

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Neurons that express the compound, ␥ -aminobutyric acid (GABA), are broadly present throughout the central nervous system, although telencephalic structures, such as the cerebral cortex, show the most abundant quantities of this neurotransmitter (Jones 1987). In the discussion that follows, the anatomy and physiology of various types of GABAergic interneurons in the cortex and hippocampus will be discussed and related to recent postmortem studies implicating this transmitter system in the pathophysiology of schizophrenia and bi- 25 , NO . 1 polar disorder and their treatment with neuroleptic drugs (for more comprehensive reviews on cortical and hippocampal neurons see: Hof et al. 1993;Freund and Buzsaki 1996;Somogyi et al. 1998). NEUROBIOLOGY OF GABAERGIC INTERNEURONSBased on Golgi-impregnation studies, Ramon y Cajal provided the first descriptions of several different morphological subtypes of interneurons in the cerebral cortex and hippocampus (Ramon y Cajal 1893, 1911. In more recent years, it has been shown that, with some overlap, different morphological subtypes also have distinct distributions, connectivity, neurochemistry, and electrophysiological properties (for reviews see Hof et al. 1993;Freund and Buzsaki 1996). It is interesting to note that every segment of a pyramidal neuron, such as the soma, dendritic branches and spines, and the initial axonal segment, receives dense GABAergic synaptic innervation (O'Kusky and Colonnier 1982;Hendry et al. 1983;Houser et al. 1983; Beaulieu et al. 1992; for reviews see Jones 1993;Freund and Buzsaki 1996). Even more interestingly, each of these segments appears to be innervated by distinct GABAergic neuronal subtypes (see below).These differences strongly suggest that each of these subtypes plays a fundamentally different role in physiological and pathological mechanisms. In the discussion that follows, cortical interneurons will be described first, since our most basic understanding of GABAergic cells is derived from these populations. In more recent years, however, similar characterizations of interneurons in hippocampus have emerged. Although these cells show some striking similarities to their cortical counterparts, there are also some unique features that distinguish them. For this reason, interneurons in the hippocampus are discussed separately. Cortex Neuroanatomical Studies of Cortical Interneurons.Various types of GABAergic neurons can be categorized according to the type of synaptic profiles they are associated with, as this has direct implications for understanding the physiological role of these cells in cortical circuits. These categories are discussed below.A XO -S OMATIC I NHIBITORY S YNAPSES (B ASKET C ELLS ). The most commonly encountered interneurons ( Figure 1A) are multipolar in shape, i.e., they may have three or more primary dendritic branches emanating from their cell bodies, some having somata that are as large as those of pyramidal neurons (Jones and Hendry 1984). Using immunocytochemistry to localize the enzyme ). These cells also ...

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GABAergic Stimulation Regulates the Phenotype of Hippocampal Interneurons through the Regulation of Brain-Derived Neurotrophic Factor

Cited by 239 publications

References 18 publications

The expression of GABA_Areceptors during the development of the rabbit retina

The expression of GABA_Areceptors during the development of the rabbit retina

Activity-dependent scaling of GABAergic synapse strength is regulated by brain-derived neurotrophic factor

GABAergic Interneurons Implications for Understanding Schizophrenia and Bipolar Disorder

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GABAergic Stimulation Regulates the Phenotype of Hippocampal Interneurons through the Regulation of Brain-Derived Neurotrophic Factor

Cited by 239 publications

References 18 publications

The expression of GABAAreceptors during the development of the rabbit retina

The expression of GABAAreceptors during the development of the rabbit retina

Activity-dependent scaling of GABAergic synapse strength is regulated by brain-derived neurotrophic factor

GABAergic Interneurons Implications for Understanding Schizophrenia and Bipolar Disorder

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The expression of GABA_Areceptors during the development of the rabbit retina

The expression of GABA_Areceptors during the development of the rabbit retina