Gabapentin: A New Agent for the Management of Epilepsy

Andrews, Carlota O; Fischer, James H.

doi:10.1177/106002809402801011

Cited by 58 publications

(26 citation statements)

References 27 publications

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“…Although GBP is structurally related to GABA, its antiepileptic activity appears unrelated to any direct effects on the GABA system [51]. GBP is characterized by distinct pharmacokinetic features that provide clinical advantages for its use.…”

Section: Gabapentinmentioning

confidence: 99%

Antiepileptic drug treatment in children

Hadjiloizou

Bourgeois

2007

Expert Review of Neurotherapeutics

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Epilepsy is one of the most common neurological disorders of childhood, and antiepileptic drugs represent the main component of its treatment. The current emphasis in epilepsy treatment is to improve quality of life, not only by suppressing seizure, but also by minimizing the side effects of medications. The last 15 years have been characterized by significant advances in the development of new agents that have helped us to get closer to this goal. Knowledge of the essential properties, key indications and interactions of each antiepileptic drug will help to optimize efficacy and reduce adverse reactions. Age is also a determining factor of the epilepsy phenotype and its treatment. This review addresses the principles of pediatric epilepsy treatment, summarizes the profile of each of the commonly used antiepileptic drugs, and provides a treatment paradigm for particular seizures and epilepsy syndromes of childhood.

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Section: Gabapentinmentioning

confidence: 99%

Antiepileptic drug treatment in children

Hadjiloizou

Bourgeois

2007

Expert Review of Neurotherapeutics

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“…3) was first shown to be an effective anticonvulsant agent in different animal models of epilepsy [154]. In humans, it prevents partial and generalized tonicclonic seizures when prescribed as monotherapy or with other drugs [155][156][157]. In animal models, gabapentin appears to block nociceptive responses, producing analgesic effects, and to possess anxiolytic-like activity [158].…”

Section: Introductionmentioning

confidence: 99%

The Glutamate Hypothesis in ALS: Pathophysiology and Drug Development

Blasco¹,

Mavel²,

Corcia³

et al. 2014

CMC

143

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“…Gabapentin is a novel anticonvulsant which was released for use in epilepsy in 1993 [8,9]. Initial case reports have indicated that gabapentin could be effective in patients with trigeminal neuralgia [10], refractory neuropathic pain [11], postherpetic neuralgia [12] or severe reflex sympathetic dystrophy [13], and that it has a good safety profile.…”

Section: Introductionmentioning

confidence: 99%

Effects of Gabapentin on the Different Components of Peripheral and Central Neuropathic Pain Syndromes: A Pilot Study

et al. 1998

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Anticonvulsants are widely used in the treatment of neuropathic pain, and are assumed to act preferentially on lancinating, shooting pain. In the present study, the effects of gabapentin, a novel anticonvulsant, were evaluated systematically on both spontaneous and evoked pain in 18 patients with peripheral nerve injuries or central lesions. Gabapentin was administered orally in gradually increasing doses up to a maximum of 2,400 mg/day. Evaluations of spontaneous ongoing and paroxysmal pain, allodynia and hyperalgesia were performed at the beginning of the study (‘baseline’) and 6 weeks after the steady-state dose had been reached. Quantitative sensory tests were used to measure detection and pain thresholds to mechanical and thermal stimuli and the responses to suprathreshold stimuli. Gabapentin induced a moderate and statistically significant relief of ongoing spontaneous pain and was particularly effective in reducing paroxysmal pain. A striking finding was the significant effect on brush-induced and cold allodynia. In contrast, no effects were observed on detection and pain thresholds to static mechanical and hot stimuli. Side effects were generally minor and did not interfere with everyday activities. The present study suggests that gabapentin has preferential antihyperalgesic and/or antiallodynic effects, and is equally effective in pain due to peripheral nerve injuries and central lesions.

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Gabapentin: A New Agent for the Management of Epilepsy

Abstract: Gabapentin appears to be a useful new AED. Further studies evaluating its use as monotherapy, in higher dosages, and in pediatric and elderly patients are required to better delineate its therapeutic role relative to that of other AEDs.

Cited by 58 publications

References 27 publications

Antiepileptic drug treatment in children

Antiepileptic drug treatment in children

The Glutamate Hypothesis in ALS: Pathophysiology and Drug Development

Effects of Gabapentin on the Different Components of Peripheral and Central Neuropathic Pain Syndromes: A Pilot Study

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