Gabapentin and Uremic Pruritus in Hemodialysis Patients

Razeghi, Effat; Eskandari, Delaram; Ganji, Mohammad Reza; Meysamie, Ali Pasha; Togha, Mansoureh; Khashayar, Patricia

doi:10.1080/08860220802595476

Cited by 101 publications

(79 citation statements)

References 18 publications

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“…53,[96][97][98] In a double-blind, crossover, RCT of 25 HD patients assigned to gabapentin 300 mg by mouth after dialysis or placebo, pruritus intensity significantly improved with gabapentin but not with placebo. 53 Similarly, in a double-blind, placebo-controlled trial of 34 HD …”

Section: Peripheral Neuropathy Treatmentmentioning

confidence: 99%

Chronic kidney disease-associated pruritus: impact on quality of life and current management challenges

Shirazian¹,

Aina²,

Park³

et al. 2017

IJNRD

111

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Chronic kidney disease-associated pruritus (CKD-aP) is a distressing, often overlooked condition in patients with CKD and end-stage renal disease. It affects ~40% of patients with end-stage renal disease and has been associated with poor quality of life, poor sleep, depression, and mortality. Prevalence estimates vary based on the instruments used to diagnose CKD-aP, and standardized diagnostic instruments are sorely needed. Treatment studies have often yielded conflicting results. This is likely related to studies that are limited by small sample size, flawed designs, and nonstandardized diagnostic instruments. Several large well-designed treatment trials have recently been completed and may soon influence CKD-aP management.

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Section: Peripheral Neuropathy Treatmentmentioning

confidence: 99%

Chronic kidney disease-associated pruritus: impact on quality of life and current management challenges

Shirazian¹,

Aina²,

Park³

et al. 2017

IJNRD

111

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“…Razeghi i wsp. [15] zaobserwowali, że większe stężenie ferrytyny oraz zmniejszone stężenie albumin i transferyny u pacjentów z PChN wiązało się z występowaniem bardziej nasilonego świądu [15]. Świąd najczęściej obejmuje skórę pleców, ramion, przedniej powierzchni klatki piersiowej oraz twarzy [2,4,6,7,12].…”

Section: Nieswoiste Zmiany Skórne U Pacjentów Ze Schyłkową Niewydolnounclassified

“…The pathogenesis of CKD-associated pruritus involves a number of factors including xerosis, hypervitaminosis A, electrolyte disorders (hypercalcaemia, hyperphosphataemia, hypermagnesaemia), secondary hyperparathyroidism, peripheral neuropathy and increased plasma concentrations of β-endorphins, μ-receptor antagonists, interleukin 2 (IL-2), IL-6, C-reactive protein (CRP), and elevated mast cell count in the skin [2,3,6,[9][10][11][12][13][14]. Razeghi et al [15] showed that increased ferritin levels and reduced albumin and transferrin levels in patients with CKD were associated with more severe skin itch [15]. Pruritus typically affects the skin on the back, shoulders, anterior surface of the chest and face [2,4,6,7,12].…”

Section: Nieswoiste Zmiany Skórne U Pacjentów Ze Schyłkową Niewydolnomentioning

confidence: 99%

Skin changes in chronic kidney disease

Przepiórka-Kosińska¹,

Chyl-Surdacka²,

Bartosińska³

et al. 2017

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Chronic kidney disease causes skin changes which may sometimes be the first sign of kidney failure. Specific skin changes include acquired perforating dermatosis, porphyria cutanea tarda, pseudoporphyria, calcinosis and nephrogenic systemic fibrosis. The majority of patients present with cutaneous manifestations which are classified as nonspecific, including xerosis, pruritus, pigmentation disturbances, nail plate abnormalities, uraemic frost and gynaecomastia. Treatment improving kidney function (dialysis therapy or kidney transplantation) also leads to the resolution of skin lesions. STRESZCZENIEPrzewlekła choroba nerek powoduje zmiany skórne, które niejednokrotnie mogą być pierwszym objawem niewydolności nerek. Do swoistych zmian skórnych należą: nabyta perforująca dermatoza, porfiria skórna późna, pseudoporfiria, zwapnienia oraz uogólnione nerkopochodne włóknienie. Zmiany zaliczane do objawów nieswoistych, takie jak suchość skóry, świąd skóry, zmiany jej zabarwienia, nieprawidłowości dotyczące płytek paznokciowych, szron mocznicowy oraz ginekomastia, są spotykane u większości pacjentów. Leczenie powodujące poprawę wydolności nerek (dializoterapia lub przeszczepienie nerki) prowadzi jednocześnie do złagodzenia lub ustąpienia objawów skórnych.

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“…2 to 5.7 Several mechanisms are cited in attempting to explain this event, such as hyperparathyroidism, 14,16,20 allergic reactions, proliferation of mast cells in the skin, iron deficiency anemia, hypervitaminosis A, xerosis, neuropathy , cytokines, bile acids, nitric oxide, electrolyte [2][3][4]21 , creatinine, total protein 5.8 , urea, ferritin, and transferrin disorders and 8 alterations of the immune system. 22 Many authors believe that altered levels of magnesium, parathyroid hormone, phosphorus, calcium and calcium/phosphorus ratio are involved in renal pruritus.…”

Section: Introductionmentioning

confidence: 99%

“…The symptom that most frequently affects these patients is pruritus, [2][3][4][5][6][7][8][9][10][11][12] ranging between 22% and 90% in prevalence. [1][2][3][4][6][7][8][9][13][14][15] It often begins six months before the start of dialysis and manifests itself in markedly different ways; it may be persistent, intense and widespread or just localized and transient. 4.14 Pruritus causes changes in quality of life and 11 has a physical and mental impact, which contribute to depression, agitation, sleep disturbances and fatigue.…”

Section: Introductionmentioning

confidence: 99%

Avaliação da associação entre as alterações no metabolismo mineral e o prurido nos pacientes em hemodiálise

Welter

Frainer

Maldotti

et al. 2011

An. Bras. Dermatol.

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FUNDAMENTOS: prurido é o sintoma mais freqüente nos pacientes nefropatas em hemodiálise. Parâmetros laboratoriais anormais têm sido encontrados, com dados conflitantes. OBJETIVO: relacionar a prevalência de prurido com alterações no metabolismo mineral de pacientes em hemodiálise. MÉTODOS: estudo caso-controle. Avaliados 105 pacientes, sendo os pacientes com prurido os casos, preencheram o questionário do protocolo de pesquisa e a escala análoga visual, os dados laboratoriais foram coletados dos prontuários eletrônicos. RESULTADOS: a média de idade foi de 51,9 anos, 59% dos pacientes eram homens e 43% dos pacientes tinham prurido. Xerodermia ocorreu em 45% dos pacientes. Níveis elevados de Ca foram demonstrados em 55% dos pacientes e 47% tinham prurido. Quanto ao fósforo 60% tinham valores elevados e 43% tinham prurido. A relação Ca/P foi normal em todos. O paratormônio mostrou-se elevado em 95% dos pacientes, todos referindo prurido. CONCLUSÃO: houve associação estatisticamente significativa entre o grupo de pacientes com prurido e xerodermia. Os níveis séricos de Cálcio, Fósforo, relação Ca/P, PTHi e o tamanho do dialisador não apresentaram associação estatisticamente significativa com o prurido. Logo, encontramos relação importante entre xerodermia e prurido, sem relação com os parâmetros laboratoriais avaliados.

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Gabapentin and Uremic Pruritus in Hemodialysis Patients

Abstract: Gabapentin is an effective agent in treating uremic pruritus.

Cited by 101 publications

References 18 publications

Chronic kidney disease-associated pruritus: impact on quality of life and current management challenges

Chronic kidney disease-associated pruritus: impact on quality of life and current management challenges

Skin changes in chronic kidney disease

Avaliação da associação entre as alterações no metabolismo mineral e o prurido nos pacientes em hemodiálise

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