Gabapentin for acute and chronic post-surgical pain

Melemeni, Aikaterini; Staikou, Chryssoula; Fassoulaki, Argyro

doi:10.22514/sv21.052007.5

Cited by 9 publications

(4 citation statements)

References 86 publications

(103 reference statements)

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“…In addition, a detailed analysis of opioids in the trauma environment was deemed redundant with previous reviews (Dijkstra, Berben, van Dongen, & Schoonhoven, 2014; Gausche-Hill et al, 2014). The summarized studies primarily focus on the acute treatment of trauma pain, though data from the postsurgical environment are sometimes included because opioid-sparing and multimodal therapy have demonstrated efficacy in this clinical setting (Laskowski, Stirling, McKay, & Lim, 2011; Melemeni, Staikou, & Fassoulaki, 2007) and trauma patients may require surgery. It should be noted that the search terms amitriptyline , massage , biofeedback , transcutaneous electrical nerve stimulation (TENS) , and touch therapy did not return any relevant recent studies.…”

Section: Resultsmentioning

confidence: 99%

“…Gabapentin and pregabalin led to decreased pain versus placebo in two double-blind studies of patients with burns (Gray et al, 2011; Rimaz et al, 2012). In addition to analgesic effects, data in the postoperative setting from reviews and a meta-analysis strongly demonstrate the opioid-sparing effects of gabapentin and pregabalin (Gilron, 2007; Melemeni et al, 2007; Zhang, Ho, & Wang, 2011). …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Exploring Opioid-Sparing Multimodal Analgesia Options in Trauma: A Nursing Perspective

Sullivan

Lyons

Montgomery

et al. 2016

Journal of Trauma Nursing

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Exploring Opioid-Sparing Multimodal Analgesia Options in Trauma: A Nursing Perspective

Sullivan

Lyons

Montgomery

et al. 2016

Journal of Trauma Nursing

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show abstract

“…Gabapentinoids seem to decrease pain scores, but not opioids used. [14] Some studies show a significant effect in pain reduction compared with opiates, [18,27–29] but some double-blinded studies, including one sponsored by the manufacturer, [18,22,30] do not show such an effect. A recent meta-analysis by Verret et al [26] evaluated the use of gabapentinoids on postoperative acute pain and did not find large difference in pain scores or MMEs, although both values were trending lower.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Multimodal analgesia is superior to opiates alone after tibial fracture in patients with substance abuse history

Lenk¹,

Strecker²,

Nolan³

2022

OTA International: The Open Access Journal of Orthopaedic Trauma

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Objectives: To evaluate the effectiveness of multimodal analgesia in patients with a tibial shaft fracture.Design: Retrospective review.Setting: Large, urban, academic center.Patients: One hundred thirty-eight patients were evaluated before implementation of multimodal analgesia. Thirty-four patients were evaluated after implementation. All patients were treated operatively with internal fixation for their tibial shaft fracture. Patients with polytrauma were excluded.Intervention: Multimodal analgesia.Main Outcome Measures: Pain levels at rest and with movement were assessed. Morphine milligram equivalents (MMEs) dosed per patient were calculated each day. Length of stay was also documented.Results: After implementation of a multimodal analgesic program, there was a statistically significant decrease in pain score at rest (4.7-4.0, P 5 0.034) and with movement (5.8-4.8, P 5 0.007). MMEs dosed in the multimodal analgesic program correlated with pain score (R 2 5 0.5), whereas before implementation of the program, MMEs dosed were not dependent on pain score (R 2 5 0.007). Patients with a history of substance abuse had the most profound effect from this paradigm change. For those with a history of substance abuse, treatment of pain using a multimodal approach reduces MMEs dosed and length of stay (5.7-3.1 days, P 5 0.016).Conclusions: Multimodal analgesia improves patient pain scores both at rest and during movement. In patients with a history of substance abuse, multimodal analgesia not only decreases pain but also decreases length of stay and MMEs dosed to levels consistent with someone who does not have a substance abuse history.

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“…When in postoperative pain there is evidence of neuropathic pain, the indication of antidepressants (amitriptyline, nortriptyline, duloxetine) and antiepileptic drugs (gabapentin, pregabalin) can relieve pain secondary to nervous lesion and different types of neuropathy 41 . Antiepileptic drugs such as gabapentin have been used to suppress both neuropathic and postoperative pain in breast surgery and hysterectomy 42 . Corticosteroids have been used as adjuvants to decrease opioid consumption and help to reduce postoperative pain.…”

Section: Non-opioid Analgesicsmentioning

confidence: 99%

Perioperative Pain Management in Gynecologic Oncology Surgery

Garza¹,

Pérez-González²

2022

GAMO

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Postoperative pain is a normal reaction to surgical intervention; however, it has been shown to increase morbidity, thus compromising the quality of recovery, which entails a delay in hospital discharge, increased risk of wound infection, and respiratory or cardiovascular complications, with an increase in mortality. Pain syndromes observed in patients with gynecologic oncology pathology result from three primary etiologies: those directly occurring due to the tumor, those deriving from treatments focused on reducing the tumor and those syndromes that are entirely independent of cancer or its treatment. Postoperative pain optimal management requires understanding the pathophysiology of pain and knowing the methods to be able to assess it in each patient, as well as knowledge on the different options available to control it. The key points that have to be considered are: the type of patient, type of surgical procedure, skills of the surgeon and anesthesiologist, and support of the working team. Improving the treatment of postoperative pain requires a broader perspective, since most healthcare providers have been shown to focus only on the postoperative period; however, ideal management is that where interventions are carried out before, during, and after surgery. (creativecommons.org/licenses/by-nc-nd/4.0/).Pain management in gynecologic oncology surgery 125

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Gabapentin for acute and chronic post-surgical pain

Abstract: Pain after surgery remains a significant clinical problem as it impairs recovery adversely and may lead to the transition

Cited by 9 publications

References 86 publications

Exploring Opioid-Sparing Multimodal Analgesia Options in Trauma: A Nursing Perspective

Exploring Opioid-Sparing Multimodal Analgesia Options in Trauma: A Nursing Perspective

Multimodal analgesia is superior to opiates alone after tibial fracture in patients with substance abuse history

Perioperative Pain Management in Gynecologic Oncology Surgery

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