Gabapentin for the treatment and prophylaxis of cluster headache

Tay, Beng A.; Kee, Warwick D. Ngan; Chung, David C.

doi:10.1053/rapm.2001.24404

Cited by 8 publications

(2 citation statements)

References 10 publications

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“…50 In another case report, a 38-year-old man diagnosed with episodic cluster headache was effectively treated with gabapentin 300 mg bid. 51 The only side effect was initial drowsiness, which disappeared after 3 doses.…”

Section: Aeds For the Prevention Of Cluster Headache: Clinical Evidenmentioning

confidence: 98%

Antiepileptic Drugs for the Treatment of Chronic and Episodic Cluster Headache: A Review

Pascual

Láinez

Dodick³

et al. 2007

Headache

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Cluster headache needs to be rapidly diagnosed and effectively managed, as the individual headache attacks that are characteristic of this disorder are excruciatingly painful and debilitating. Preventive therapies are necessary to reduce the frequency of attacks during the cluster period. However, preventive therapy for this disorder is limited by a lack of controlled evidence of efficacy and the potential for systemic toxicity. Recent progress has been made in understanding both the pathophysiological mechanisms underlying cluster headache and the mechanisms of action of the antiepileptic drug class for the treatment of primary headache syndromes. Newly available preliminary clinical trial data evaluating antiepileptic drugs for the prevention of cluster headache suggest that these agents may be effective and that further evaluation in randomized, placebo-controlled trials is warranted.

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Section: Aeds For the Prevention Of Cluster Headache: Clinical Evidenmentioning

confidence: 98%

Antiepileptic Drugs for the Treatment of Chronic and Episodic Cluster Headache: A Review

Pascual

Láinez

Dodick³

et al. 2007

Headache

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“…Small open-label studies and case reports have indicated that the following drugs may be effective for cluster headache: methylphenidate, 134 baclofen, 135 tizanidine, 136 clonidine, 137 pizotifen, 138 chlorpromazine, 139 histamine, 140 leuprolide, 141 eletriptan, 142 and gabapentin. [143][144][145] The experience with these drugs and several others such as botulinum toxin, 146 cyproheptadine, diltiazem, and tamoxifen is too limited to support their routine use in the treatment of cluster headache. 147 Refractory Cluster Headache…”

Section: Othermentioning

confidence: 99%

Diagnosis and Treatment of Cluster Headache

Capobianco

Dodick

2006

Semin Neurol

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Cluster headache is an uncommon yet distinctive neurovascular syndrome occurring in either episodic or chronic patterns. The most unique feature of cluster headache is the unmistakable circadian and circannual periodicity. The attacks are stereotypical, that is, of extreme intensity, of short duration, occurring unilaterally, and associated with robust signs and symptoms of autonomic dysfunction. Unlike migraine, during an attack the patient with cluster headache often paces about. Attacks frequently occur at night, awakening the patient from sleep. Although the pathophysiology of cluster headache remains to be fully elucidated, several seminal observations have recently been made. The medical treatment of cluster headache includes acute, transitional, and maintenance prophylaxis. Agents used for acute therapy include inhalation of oxygen and triptans, such as sumatriptan, and dihydroergotamine. Transitional prophylaxis refers to the short-term use of fast-acting agents. This typically involves either corticosteroids or ergotamine derivatives. The mainstay of prophylactic therapy is verapamil. Lithium, divalproex sodium, or topiramate may also be useful. As the sophistication of functional neuroimaging increases, so too will our ability to better understand the anatomic and metabolic perturbations that underlie cluster headache.

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Trigeminal Autonomic Cephalalgias

Martelletti¹

2023

Non-Migraine Primary Headaches in Medicine

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Gabapentin for the treatment and prophylaxis of cluster headache

Abstract: Gabapentin was effective in the treatment of a patient with cluster headache. Further investigation of gabapentin compared with conventional treatments and placebo is warranted.

Cited by 8 publications

References 10 publications

Antiepileptic Drugs for the Treatment of Chronic and Episodic Cluster Headache: A Review

Antiepileptic Drugs for the Treatment of Chronic and Episodic Cluster Headache: A Review

Diagnosis and Treatment of Cluster Headache

Trigeminal Autonomic Cephalalgias

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