Gabapentin-Induced Liver Toxicity

Abstract

The aim in reporting this case is to highlight the potential effect foscarnet has in inducing NDI. It is important for practitioners to review a patient's medications in detail in patients who develop NDI because missing potential inciting agents can lead to severe electrolyte disturbances and adverse outcomes.Overall, foscarnet is a less common cause of NDI; however it must be kept on the differential for when patients receiving this medication present with the characteristic clinical and laboratory findings of NDI.NDI is a serious side effect for the use of foscarnet in the management of CMV retinitis. However, despite the fact of it being rare to occur, in immunocompromised patients (particularly patients with cancers, as it is the case in our reported patient), NDI is more likely to be reported with a higher rate.

Did you choose appropriate mouthwash for managing chemoradiotherapy-induced oral mucositis? The therapeutic effect compared by a Bayesian network meta-analysis.

“…In fact, the pharmacological effects of gabapentin mainly depend on the inhibitory neurotransmitter γ-aminobutyric acid in the central nervous system (35); local or external application of gabapentin cannot fully exert its function. Furthermore, many studies have shown that gabapentin had specific cytotoxic effects on the liver, kidney, and hematopoietic system (36)(37)(38), making it likely to aggravate the damage to the mucosal epithelial cells when used locally, especially when the oral-mucosal barrier dysfunctions.…”