Gabapentin-Induced Rhabdomyolysis in a Patient with Diabetic Neuropathy

Abstract

Gabapentin (GBP) is a drug which is frequently used in diabetic neuropathy.

A case of gabapentin overdose induced rhabdomyolysis requiring renal replacement therapy

“…Seven reported cases of gabapentin-induced myopathy in PubMed database but only five cases are rhabdomyolysis, see Table2. 2,[14][15][16][17] Lipson et al reported two cases of myopathy in patients receiving hemodialysis developed neuromuscular symptoms and a lower level of elevation of creatine kinase after starting gabapentin therapy with longer symptoms onset (2 weeks and 6 weeks, respectively). Patient is already on hemodialysis, so it is less likely it is acute rhabdomyolysis per se.…”

A case of gabapentin‐induced rhabdomyolysis requiring renal replacement therapy

“…To our knowledge, there are only five cases of gabapentin‐associated rhabdomyolysis in the literature (Table ). Lipson et al reported two cases of myopathy in patients receiving daily hemodialysis.…”

“…This patient did not need renal replacement therapy but died from sudden respiratory failure. Bilgir et al reported a patient with underlying chronic kidney disease suspected of gabapentin‐induced rhabdomyolysis. Torregrosa et al also reported a case of rhabdomyolysis with shorter symptom onset time (48 hours) after administration of high gabapentin dosage (1800 mg/day).…”

Gabapentin for chronic refractory cough: A system review and meta-analysis

“…Studies have shown that gabapentin is safe in most times. The most serious adverse effects reported were rhabdomyolysis and acute renal insufficiency in 2 diabetic patients, both of which recovered after treatment [ 68 , 69 ]. In a retrospective case series, 48 patients with overdosing gabapentin (vary from 600 mg to 3000 mg) suffered no or only mild adverse effects, and the highest tolerated dose was 48g [ 70 ].…”