Gabapentin reduces preoperative anxiety and pain catastrophizing in highly anxious patients prior to major surgery: a blinded randomized placebo-controlled trial

Predictors of Postoperative Pain Trajectories in Adolescent Idiopathic Scoliosis

“…7 , 31 -34 Thus, anxiety may be a general vulnerability factor for poorer outcomes after surgical trauma and may be an important target for pre-emptive intervention as well. 35 Although baseline pain and anxiety predicted poorer improvement in pain after surgery, the level of confi dence in ability to control pain (pain coping effi cacy) was associated both with lower preoperative pain and a more rapid rate of pain improvement after surgery. In the broader pediatric pain literature, high pain coping effi cacy is associated with higher experimental pain tolerance, 36 , 37 whereas perceived helplessness about pain is associated with lower pain tolerance, higher pain intensity, and greater pain-related disability.…”

Can Preoperative Psychological Assessment Predict Outcomes After Temporomandibular Joint Arthroscopy?

“…Psychological counseling, music, preoperative education, hypnosis, gabapentin, and pregabalin have been shown to decrease anxiety and improve outcomes after various surgical procedures. [41][42][43][44][45][46] Although there is no literature to support or refute the use of selective serotonin reuptake inhibitors or serotonin norepinephrine reuptake inhibitors in the management of preoperative anxiety, these classes of drugs are routinely used to treat generalized anxiety disorder and could be beneficial in the perioperative period in select patients undergoing surgical procedures for TMD. Further outcome-based studies in the surgical management of TMD that assess anxiety are needed.…”

Pregabalin reduces postoperative opioid consumption and pain for 1 week after hospital discharge, but does not affect function at 6 weeks or 3 months after total hip arthroplasty

“…baseline anxiety >5/10) undergoing major surgery, significantly reduced preoperative anxiety and pain catastrophizing before major surgery. 56 A recent systematic review has also found that pain catastrophizing predicts CPSP after total knee arthroplasty. 57 This emerging literature suggests that patients should be screened before surgery for psychological vulnerabilities, and based on the results, psychological interventions, in addition to multimodal preventive analgesic strategies such as the ones implemented in this trial, should become a mainstay for perioperative postsurgical care.…”