Gadofosveset-Enhanced Magnetic Resonance Angiography of the Thoracic Vasculature in the Equilibrium Phase

Kim, Charles Y.; Heye, Tobias; Bashir, Mustafa R.; Gebhard, T.A.; Merkle, Elmar M.

doi:10.1097/rct.0b013e318299dde9

Cited by 6 publications

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gadofosveset trisodium’s primary advantage is its increased duration of intravascular residence, offering the opportunity to obtain equilibrium images (up to 45–60 min after injection in adults) [13]. GT’s higher relaxivity also allows a smaller total dose of gadolinium to be given (standard dose is 0.03 mmol/kg), and even lower doses of GT have been reported as well [14]. No cases of nephrogenic systemic fibrosis have been reported with GT to date, but given renal clearance, caution should be used in patients with renal impairment, similar to extracellular gadolinium contrast agents [12, 13].…”

Section: Discussionmentioning

confidence: 99%

Improved high-resolution pediatric vascular cardiovascular magnetic resonance with gadofosveset-enhanced 3D respiratory navigated, inversion recovery prepared gradient echo readout imaging compared to 3D balanced steady-state free precession readout imaging

Tandon

Hashemi

Parks

et al. 2016

Journal of Cardiovascular Magnetic Resonance

View full text Add to dashboard Cite

BackgroundImproved delineation of vascular structures is a common indication for cardiovascular magnetic resonance (CMR) in children and requires high spatial resolution. Currently, pre-contrast 3D, respiratory navigated, T2-prepared, fat saturated imaging with a bSSFP readout (3D bSSFP) is commonly used; however, these images can be limited by blood pool inhomogeneity and exaggeration of metal artifact. We compared image quality of pediatric vasculature obtained using standard 3D bSSFP to 3D, respiratory navigated, inversion recovery prepared imaging with a gradient echo readout (3D IR GRE) performed after administration of gadofosveset trisodium (GT), a blood pool contrast agent.MethodsFor both sequences, VCG triggering was used with acquisition during a quiescent period of the cardiac cycle. 3D bSSFP imaging was performed pre-contrast, and 3D IR GRE imaging was performed 5 min after GT administration. We devised a vascular imaging quality score (VIQS) with subscores for coronary arteries, pulmonary arteries and veins, blood pool homogeneity, and metal artifact. Scoring was performed on axial reconstructions of isotropic datasets by two independent readers and differences were adjudicated. Signal- and contrast-to-noise (SNR and CNR) calculations were performed on each dataset.ResultsThirty-five patients had both 3D bSSFP and 3D IR GRE imaging performed. 3D IR GRE imaging showed improved overall vascular imaging compared to 3D bSSFP when comparing all-patient VIQS scores (n = 35, median 14 (IQR 11–15), vs 6 (4–10), p < 0.0001), and when analyzing the subset of patients with intrathoracic metal (n = 17, 16 (14–17) vs. 5 (2–9), p < 0.0001). 3D IR GRE showed significantly improved VIQS subscores for imaging the RCA, pulmonary arteries, pulmonary veins, and blood pool homogeneity. In addition, 3D IR GRE imaging showed reduced variability in both all-patient and metal VIQS scores compared to 3D bSSFP (p < 0.05). SNR and CNR were higher with 3D IR GRE in the left ventricle and left atrium, but not the pulmonary arteries.ConclusionsRespiratory navigated 3D IR GRE imaging after GT administration provides improved vascular CMR in pediatric patients compared to pre-contrast 3D bSSFP imaging, as well as improved imaging in patients with intrathoracic metal. It is an excellent alternative in this challenging patient population when high spatial resolution vascular imaging is needed.

show abstract

Section: Discussionmentioning

confidence: 99%

Improved high-resolution pediatric vascular cardiovascular magnetic resonance with gadofosveset-enhanced 3D respiratory navigated, inversion recovery prepared gradient echo readout imaging compared to 3D balanced steady-state free precession readout imaging

Tandon

Hashemi

Parks

et al. 2016

Journal of Cardiovascular Magnetic Resonance

View full text Add to dashboard Cite

show abstract

“…With a high relaxivity and a long blood retention time, N2(Gd) nanoparticles could potentially be considered for application in magnetic resonance angiography at a low dose of gadolinium. 56,57 hydrophobic guest encapsulation…”

Section: Biodistribution Studymentioning

confidence: 99%

Synthesis and in vivo magnetic resonance imaging evaluation of biocompatible branched copolymer nanocontrast agents

Jackson¹,

Chandrasekharan²,

Shi³

et al. 2015

IJN

View full text Add to dashboard Cite

Branched copolymer nanoparticles ( D h =20–35 nm) possessing 1,4,7, 10-tetraazacyclododecane- N , N ′, N ″, N ‴-tetraacetic acid macrocycles within their cores have been synthesized and applied as magnetic resonance imaging (MRI) nanosized contrast agents in vivo. These nanoparticles have been generated from novel functional monomers via reversible addition–fragmentation chain transfer polymerization. The process is very robust and synthetically straightforward. Chelation with gadolinium and preliminary in vivo experiments have demonstrated promising characteristics as MRI contrast agents with prolonged blood retention time, good biocompatibility, and an intravascular distribution. The ability of these nanoparticles to perfuse and passively target tumor cells through the enhanced permeability and retention effect is also demonstrated. These novel highly functional nanoparticle platforms have succinimidyl ester-activated benzoate functionalities within their corona, which make them suitable for future peptide conjugation and subsequent active cell-targeted MRI or the conjugation of fluorophores for bimodal imaging. We have also demonstrated that these branched copolymer nanoparticles are able to noncovalently encapsulate hydrophobic guest molecules, which could allow simultaneous bioimaging and drug delivery.

show abstract

Extracardiac applications of MR blood pool contrast agent in children

Farmakis

Khanna

2014

Pediatr Radiol

View full text Add to dashboard Cite

Magnetic resonance (MR) angiography has significantly reduced the need for diagnostic conventional angiography and is preferred over CT angiography in children because of its lack of ionizing radiation. The availability of gadofosveset trisodium (the only clinically approved blood pool MR contrast agent) has led to an increase in applications of MR for vascular imaging and an improvement in diagnostic quality of MR angiography. Gadofosveset is a gadolinium-based contrast agent that binds reversibly to albumin, resulting in increased paramagnetic effect and longer intravascular residence. This allows for high-resolution arterial and venous MR angiography, assessment of flow characteristics of vascular malformations, dynamic vascular imaging, and multi-station imaging with a single low-dose gadolinium contrast injection. The purpose of this pictorial essay is to facilitate understanding of the kinetics and safety profile of gadofosveset trisodium, discuss technical aspects of imaging, and illustrate advantages and extracardiac applications in pediatric body imaging.

show abstract

Gadofosveset-Enhanced Magnetic Resonance Angiography of the Thoracic Vasculature in the Equilibrium Phase

Abstract: Gadofosveset-enhanced MRA of the thoracic vessels in the equilibrium phase in healthy volunteers resulted in adequate vessel visualization, even when dose reduction was performed.This trial was registered with clinicaltrials.gov, identifier NCT01431300.

Cited by 6 publications

References 1 publication

Improved high-resolution pediatric vascular cardiovascular magnetic resonance with gadofosveset-enhanced 3D respiratory navigated, inversion recovery prepared gradient echo readout imaging compared to 3D balanced steady-state free precession readout imaging

Improved high-resolution pediatric vascular cardiovascular magnetic resonance with gadofosveset-enhanced 3D respiratory navigated, inversion recovery prepared gradient echo readout imaging compared to 3D balanced steady-state free precession readout imaging

Synthesis and in vivo magnetic resonance imaging evaluation of biocompatible branched copolymer nanocontrast agents

Extracardiac applications of MR blood pool contrast agent in children

Contact Info

Product

Resources

About