Gadolinium—associated nephrogenic systemic fibrosis

McKoy, June M.; Laumann, Anne E.; Samaras, Athena T.; Lacouture, Mario E.; West, Dennis P.; Raisch, Dennis W.; Obadina, Eniola; Fajolu, Olukemi; Reilly, Lauren; Bennett, Charles L.

doi:10.1016/s1548-5315(11)70463-6

Cited by 2 publications

(4 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…40 SI, SNR and CNR showed statistically significant differences between the two sequences on a per patient level, but there was no difference between normal and ischemic segments.…”

Section: Si Snr and Cnrmentioning

confidence: 70%

“…In T1-weighted images, contrast enhancement is seen as a higher signal, bright on the image [39]. The use of Gd contrast media has been associated with nephrogenic systemic fibrosis (NSF) in patients with renal failure [40]. To avoid this potential complication, use of contrast media should in general be avoided if the Glomerular Filtration Rate (GFR) is lower than 30 ml min -1 per 1.73 m 2 [41].…”

Section: Safetymentioning

confidence: 99%

“…When contrast media was used patients with GRF≤30 were excluded due to the risk for adverse side effects [40,41].…”

Section: Justicementioning

confidence: 99%

See 2 more Smart Citations

Magnetic Resonance Imaging of the Heart : Image quality, measurement accuracy and patient experience

Ahlander¹

2016

Linköping University Medical Dissertations

View full text Add to dashboard Cite

Background: Non-invasive diagnostic imaging of atherosclerotic coronary artery disease (CAD) is frequently carried out with cardiovascular magnetic resonance imaging (CMR) or myocardial perfusion single photon emission computed tomography (MPS). CMR is the gold standard for the evaluation of scar after myocardial infarction and MPS the clinical gold standard for ischemia. Magnetic Resonance Imaging (MRI) is at times difficult for patients and may induce anxiety while patient experience of MPS is largely unknown. Aims: To evaluate image quality in CMR with respect to the sequences employed, the influence of atrial fibrillation, myocardial perfusion and the impact of patient information. Further, to study patient experience in relation to MRI with the goal of improving the care of these patients. Method: Four study designs have been used. In paper I, experimental cross-over, paper (II) experimental controlled clinical trial, paper (III) psychometric crosssectional study and paper (IV) prospective intervention study. A total of 475 patients ≥ 18 years with primarily cardiac problems (I-IV) except for those referred for MRI of the spine (III) were included in the four studies. Result: In patients (n=20) with atrial fibrillation, a single shot steady state free precession (SS-SSFP) sequence showed significantly better image quality than the standard segmented inversion recovery fast gradient echo (IR-FGRE) sequence (I). In first-pass perfusion imaging the gradient echo-echo planar imaging sequence (GREEPI) (n=30) had lower signal-to-noise and contrast–to-noise ratios than the steady state free precession sequence (SSFP) (n=30) but displayed a higher correlation with the MPS results, evaluated both qualitatively and quantitatively (II). The MRIAnxiety Questionnaire (MRI-AQ) was validated on patients, referred for MRI of either the spine (n=193) or the heart (n=54). The final instrument had 15 items divided in two factors regarding Anxiety and Relaxation. The instrument was found to have satisfactory psychometric properties (III). Patients who prior CMR viewed an information video scored significantly (lower) better in the factor Relaxation, than those who received standard information. Patients who underwent MPS scored lower on both factors, Anxiety and Relaxation. The extra video information had no effect on CMR image quality (IV). Conclusion: Single shot imaging in atrial fibrillation produced images with less artefact than a segmented sequence. In first-pass perfusion imaging, the sequence GRE-EPI was superior to SSFP. A questionnaire depicting anxiety during MRI showed that video information prior to imaging helped patients relax but did not result in an improvement in image quality

show abstract

“…40 SI, SNR and CNR showed statistically significant differences between the two sequences on a per patient level, but there was no difference between normal and ischemic segments.…”

Section: Si Snr and Cnrmentioning

confidence: 70%

Section: Safetymentioning

confidence: 99%

See 1 more Smart Citation

Magnetic Resonance Imaging of the Heart : Image quality, measurement accuracy and patient experience

Ahlander¹

2016

Linköping University Medical Dissertations

View full text Add to dashboard Cite

show abstract

“…16, 17 FDA reports do not include information on specific product types (for sADRs involving pharmaceutical classes) pathology, treatment or outcome. AERS was utilized to evaluate pure red cell aplasia (PRCA) following epoetin administration in chronic kidney disease (CKD) patients ( n = 170 cases) and NSF post-magnetic resonance angiography with gadolinium ( n = 351 cases); 18, 19 relevant individual case reports for these two sADRs were incomplete, often lacking information about which epoetin or gadolinium product had been administered.…”

Section: Resultsmentioning

confidence: 99%

Results from the First Decade of Research Conducted by the Research on Adverse Drug Events and Reports (RADAR) Project

McKoy¹,

Fisher²,

Courtney³

et al. 2013

Drug Saf

Self Cite

View full text Add to dashboard Cite

Introduction In 1998, a multidisciplinary team of investigators initiated the Research on Adverse Drug events And Reports (RADAR) project, a post-marketing surveillance effort that systematically investigates and disseminates information describing serious and previously unrecognized serious adverse drug and device reactions (sADRs). Objective Herein, we describe the findings, dissemination efforts, and lessons learned from the first decade of the RADAR project. Methods After identifying serious and unexpected clinical events suitable for further investigation, RADAR collaborators derived case information from physician queries, published and unpublished clinical trials, case reports, US FDA databases and manufacturer sales figures. Study Selection All major RADAR publications from 1998 to the present are included in this analysis. Data Extraction For each RADAR publication, data were abstracted on data source, correlative basic science findings, dissemination and resultant safety information. Results RADAR investigators reported 43 serious ADRs. Data sources included case reports (17 sADRs), registries (5 sADRs), referral centers (8 sADRs) and clinical trial reports (13 sADRs). Correlative basic science findings were reported for ten sADRs. Thirty-seven sADRS were described as published case reports (5 sADRs) or published case-series (32 sADRs). Related safety information was disseminated as warnings or boxed warnings in the package insert (17 sADRs) and/or `Dear Healthcare Professional' letters (14 sADRs). Conclusion An independent National Institutes of Health-funded post-marketing surveillance programme can supplement existing regulatory and pharmaceutical manufacturer supported drug safety initiatives.

show abstract

Gadolinium—associated nephrogenic systemic fibrosis

Abstract: The authors explain why physicians should refrain from ordering MRIs for patients with renal dysfunction unless the test is essential to provide diagnostic information. A possibly class-wide toxicity from the contrast agent gadolinium has been reported.

Cited by 2 publications

References 3 publications

Magnetic Resonance Imaging of the Heart : Image quality, measurement accuracy and patient experience

Magnetic Resonance Imaging of the Heart : Image quality, measurement accuracy and patient experience

Results from the First Decade of Research Conducted by the Research on Adverse Drug Events and Reports (RADAR) Project

Contact Info

Product

Resources

About