Gadolinium borate and iron oxide bioconjugates: Nanocomposites of next generation with multifunctional applications

İçten, Okan; Köse, Dursun Ali; Matissek, Stephan J.; Misurelli, Jason A.; Elsawa, Sherine F.; Hosmane, Narayan S.; Zümreoǧlu‐Karan, Birgül

doi:10.1016/j.msec.2018.06.042

Cited by 32 publications

(16 citation statements)

References 40 publications

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“…The FT‐IR spectra of silica‐coated Gd‐BTC‐MOF_2 (Gd‐BTC‐MOF_2@SiO 2 ) are given in Figure 9a. The new observed strong band at the 1078 cm −1 in the red spectrum is the characteristic peak related to Si−O−Si asymmetric stretching for SiO 2, and the band at 820 cm −1 associated with Si−O−Si symmetric stretching showed overlap with Gd‐BTC‐MOF 2, indicating the presence of silica in the Gd‐BTC‐MOF_2 [33] . The 10 B modification of Gd‐BTC‐MOF_2@SiO 2 was performed according to the literature procedures, which were used for preparing silica‐supported boric acid catalysts, [34] with some changes that 10 B 2 O 3 was used instead of H 3 BO 3 as a boron source.…”

Section: Resultsmentioning

confidence: 88%

Preparation of Gadolinium‐Based Metal‐Organic Frameworks and the Modification with Boron‐10 Isotope: A Potential Dual Agent for MRI and Neutron Capture Therapy Applications

İçten

2021

ChemistrySelect

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Cancer has recently begun to occur very commonly in humans, and the number of new cancer cases and deaths is also increasing year by year. To reduce these numbers, the development of new materials, which have the potential to be used for both diagnostic and therapeutic purposes, is very significant for sensitively detecting and effectively destroying cancer cells. Therefore, this work purposes the development of gadolinium‐based metal‐organic frameworks (Gd‐MOFs) via solvothermal method under various conditions such as the use of different ligands types, the presence or absence of PVP and variable ligand/metal ratios, and the preparation of silica‐coated and 10B modified Gd‐MOF nanocomposites to fabricate as the potential candidate for simultaneous uses in MRI and the combined neutron capture therapy (GdNCT and BNCT) applications. The XRD patterns of Gd‐MOFs showed the formation of [Gd2(BDC)3(DMF)2(H2O)] structures with 1,4 H2BDC ligand and [Gd(BTC)] structures with 1,3,5 H3BTC ligand. In the presence of PVP by using the least amount of ligands, experimental ligand/Gd ratios were calculated as 1.52 and 1.06 for [Gd2(BDC)3(DMF)2(H2O)] and [Gd(BTC)], respectively, which are very close to theoretical ratio. After the silica coating and 10B modification, the surface appearance of the prepared nanocomposite changed in general, and Gd/10B ratio into nanocomposite was calculated as 3.0, indicating that it could be a useful candidate for the simultaneous GdBNCT and MRI applications.

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Section: Resultsmentioning

confidence: 88%

Preparation of Gadolinium‐Based Metal‐Organic Frameworks and the Modification with Boron‐10 Isotope: A Potential Dual Agent for MRI and Neutron Capture Therapy Applications

İçten

2021

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“…Among these techniques, signal amplification labels relying on the enzyme or DNA labeling, dye labeling, and fluorophore labeling have exhibited great promise thanks to the synchronous properties [94,97,98]. Among numerous composite materials, the magneto-fluorescent nanocomposites have a great potential application due to their merits such as optical activity (biolabeling and bioimaging of fluorescent particles) and magnetic field guide opportunity [99][100][101][102]. Fluorometric assays have many advantages for biological applications such as higher sensitivity caused by their robust chemical and optical properties.…”

Section: Fluorescence Spectroscopymentioning

confidence: 99%

Optical-Based (Bio) Sensing Systems Using Magnetic Nanoparticles

2019

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In recent years, various reports related to sensing application research have suggested that combining the synergistic impacts of optical, electrical or magnetic properties in a single technique can lead to a new multitasking platform. Owing to their unique features of the magnetic moment, biocompatibility, ease of surface modification, chemical stability, high surface area, high mass transference, magnetic nanoparticles have found a wide range of applications in various fields, especially in sensing systems. The present review is comprehensive information about magnetic nanoparticles utilized in the optical sensing platform, broadly categorized into four types: surface plasmon resonance (SPR), surface-enhanced Raman spectroscopy (SERS), fluorescence spectroscopy and near-infrared spectroscopy and imaging (NIRS) that are commonly used in various (bio) analytical applications. The review also includes some conclusions on the state of the art in this field and future aspects.

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“…However, there are very few studies in the literature related to the development and surface modifications of metal borate structures that could be useful in combined therapies. [22] Metal borates have various structural chemistry, such as phosphates and silicates, and can be prepared from cheap oxide materials. [23] Besides, these metal borates can have different structures like warwickite, ludwigite, norbergite, and calcite, which contain trigonal or tetragonal boron units.…”

Section: Introductionmentioning

confidence: 99%

“…Generally, borate structures have attracted attention because of their solubility, short biological half-life, biocompatible properties, and adjustable properties according to the applications. [22,25] Based on all the above points, the purpose of this study is the synthesis of iron borates (Fe 3 BO 6 and FeBO 3 ) with different morphologies and the coating of these iron borates with polydopamine (PDA) to increase the solubility in aqueous media, biocompatibility and also to contribute to the reduction of gold particles on the surface of borates and the deposition of gold nanoparticles on the surface and investigation of photothermal features.…”

Section: Introductionmentioning

confidence: 99%

The Design of Gold Decorated Iron Borates (Fe₃BO₆ and FeBO₃) for Photothermal Therapy and Boron Carriers

İçten

2021

Eur J Inorg Chem

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Cancer remains one of the serious diseases that threaten health, as treatment methods cannot meet the practical needs at the desired level. Therefore, developing new materials that can be used in cancer treatment is an essential effort. The purpose of this study was to develop new materials for boron neutron capture therapy (BNCT) as boron carriers and for photothermal therapy (PTT). Hence, iron borates were prepared with different morphologies and then coated with polydopamine (PDA) to increase the solubility and biocompatibility and also to contribute to the reduction in gold particles. Lastly, gold nanoparticles were deposited on the surface of iron borates, and the photothermal performance of the gold-decorated and PDA-coated iron borates (Fe 3 BO 6 @PDAÀ Au and FeBO 3 @PDAÀ Au) was investigated under 808 nm NIR laser. After 900 s irradiation, the temperatures of the dispersions of Fe 3 BO 6 @PDAÀ Au and FeBO 3 @PDAÀ Au nanoparticles reached 45.8 and 43.2°C, respectively. Additionally, the approximate numbers of boron atoms per milligram of Fe 3 BO 6 @PDAÀ Au and FeBO 3 @PDAÀ Au nanoparticles were calculated to be 1.23 × 10 18 B mg À 1 and 2.79 × 10 18 B mg À 1 , respectively. In addition to PTT, the functional Fe 3 BO 6 @PDAÀ Au and FeBO 3 @PDAÀ Au nanoparticles introduced herein could be helpful in BNCT applications.

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Gadolinium borate and iron oxide bioconjugates: Nanocomposites of next generation with multifunctional applications

Cited by 32 publications

References 40 publications

Preparation of Gadolinium‐Based Metal‐Organic Frameworks and the Modification with Boron‐10 Isotope: A Potential Dual Agent for MRI and Neutron Capture Therapy Applications

Preparation of Gadolinium‐Based Metal‐Organic Frameworks and the Modification with Boron‐10 Isotope: A Potential Dual Agent for MRI and Neutron Capture Therapy Applications

Optical-Based (Bio) Sensing Systems Using Magnetic Nanoparticles

The Design of Gold Decorated Iron Borates (Fe₃BO₆ and FeBO₃) for Photothermal Therapy and Boron Carriers

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Gadolinium borate and iron oxide bioconjugates: Nanocomposites of next generation with multifunctional applications

Cited by 32 publications

References 40 publications

Preparation of Gadolinium‐Based Metal‐Organic Frameworks and the Modification with Boron‐10 Isotope: A Potential Dual Agent for MRI and Neutron Capture Therapy Applications

Preparation of Gadolinium‐Based Metal‐Organic Frameworks and the Modification with Boron‐10 Isotope: A Potential Dual Agent for MRI and Neutron Capture Therapy Applications

Optical-Based (Bio) Sensing Systems Using Magnetic Nanoparticles

The Design of Gold Decorated Iron Borates (Fe3BO6 and FeBO3) for Photothermal Therapy and Boron Carriers

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The Design of Gold Decorated Iron Borates (Fe₃BO₆ and FeBO₃) for Photothermal Therapy and Boron Carriers