Gadolinium-doped Au@prussian blue nanoparticles as MR/SERS bimodal agents for dendritic cell activating and tracking

Zhang, Cai; Xu, Zhenghao; Di, Huixia; Zeng, Er‐Zao; Jiang, Ying; Liu, Dingbin

doi:10.7150/thno.42114

Cited by 33 publications

(40 citation statements)

References 36 publications

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“…Specifically, BSA shows seven characteristic peaks at 617, 650, 1219, 1355, 1499, 1522, and 1650 cm –1 , which could be attributed to C–C twisting, OH out-of-plane bending, the amine III of proteins, tryptophan, CC stretching in a benzenoid ring, carotene, and amide I, respectively. − These peaks are almost missing in the case of LYS and OVA. Six peaks that were observed in SERS spectra of OVA are assigned to tryptophan, collagen, d(CH), υs COO – (IgG), CC stretching in benzenoid ring, and protein amide I absorption from left to right, respectively. − SERS features from LYS were also distinguishable from two other proteins. They are dominated by the bands of amino acids, such as the C–S stretching mode of cysteine, proline, phenylalanine, tyrosine, and amide I band of proteins, due to CO stretching (at 653, 825, 1032, 1164, and 1600 cm –1 , respectively). , These differences may be correlated with different amino acid species and protein spatial structures and, therefore, produce a signature pattern that allows us to distinguish three proteins.…”

Section: Resultsmentioning

confidence: 95%

Dual Functions of a Au@AgNP-Incorporated Nanocomposite Desalination Membrane with an Enhanced Antifouling Property and Fouling Detection Via Surface-Enhanced Raman Spectroscopy

Zhang

Acharya

Tang

et al. 2021

ACS Appl. Mater. Interfaces

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Membrane fouling has remained a major challenge limiting the wide application of membrane technology because it reduces the efficiency and shortens the lifespan of the membrane, thus increasing the operation cost. Herein we report a novel dual-function nanocomposite membrane incorporating silver-coated gold nanoparticles (Au@AgNPs) into a sulfosuccinic acid (SSA) cross-linked poly(vinyl alcohol) (PVA) membrane for a pervaporation desalination. Compared with the control PVA membrane and PVA/SSA membrane, the Au@AgNPs/PVA/SSA membrane demonstrated a higher water flux and better salt rejection as well as an enhanced antifouling property. More importantly, Au@AgNPs provided an additional function enabling a foulant detection on the membrane surface via surface-enhanced Raman spectroscopy (SERS) as Au@AgNPs could amplify the Raman signals as an SERS substrate. Distinct SERS spectra given by a fouled membrane helped to distinguish different protein foulants from their characteristic fingerprint peaks. Their fouling tendency on the membrane was also revealed by comparing the SERS intensities of mixed foulants on the membrane surface. The Au@AgNPs/PVA/SSA nanocomposite membrane presented here demonstrated the possibility of a multifunction membrane to achieve both antifouling and fouling detection, which could potentially be used in water treatment.

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Section: Resultsmentioning

confidence: 95%

Dual Functions of a Au@AgNP-Incorporated Nanocomposite Desalination Membrane with an Enhanced Antifouling Property and Fouling Detection Via Surface-Enhanced Raman Spectroscopy

Zhang

Acharya

Tang

et al. 2021

ACS Appl. Mater. Interfaces

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“…Tracking the migration of various cells to different systems in vivo is essential to assess the effectiveness of immunotherapy. Zhang et al demonstrated the good performance of Au@PB-Gd @ovalbumin NPs (APG@OVA NPs), which enables PBs to coordinate core with gold nanoparticles in cyanide (CN) binding for dendritic cell (DC) activation and labeling [ 86 ]. The APG@OVA NPs agents could not only activate and label DCs, but also monitor DC movement in real time and accurately profile DC distribution in the lymphatic system.…”

Section: Application Of Enzyme Activity Of Pbnpsmentioning

confidence: 99%

Synthesis of Prussian Blue Nanoparticles and Their Antibacterial, Antiinflammation and Antitumor Applications

Liu

et al. 2022

Pharmaceuticals

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In recent years, Prussian blue nanoparticles (PBNPs), also named Prussian blue nano-enzymes, have been shown to demonstrate excellent multi-enzyme simulation activity and anti-inflammatory properties, and can be used as reactive oxygen scavengers. Their good biocompatibility and biodegradability mean that they are ideal candidates for in vivo use. PBNPs are highly efficient electron transporters with oxidation and reduction activities. PBNPs also show considerable promise as nano-drug carriers and biological detection sensors owing to their huge specific surface area, good chemical characteristics, and changeable qualities, which might considerably increase the therapeutic impact. More crucially, PBNPs, as therapeutic and diagnostic agents, have made significant advances in biological nanomedicine. This review begins with a brief description of the synthesis methods of PBNPs, then focuses on the applications of PBNPs in tissue regeneration and inflammation according to the different properties of PBNPs. This article will provide a timely reference for further study of PBNPs as therapeutic agents.

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“…Through the coating of ovalbumin (OVA) physically, APG@OVA NPs were provided. 47 First step: The Au NPs were prepared through the classic sodium citrate reduction process using sodium citrate and HAuCl 4 solutions. Second step: K 4 [Fe(CN) 6 ] and FeCl 3 were applied as the Prussian blue nanoparticles (PB) agent, which was reacted with GdCl 3 .…”

Section: Au–magnetic Organic Hybrid Core–shellsmentioning

confidence: 99%

New advances on Au–magnetic organic hybrid core–shells in MRI, CT imaging, and drug delivery

2021

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Gadolinium-doped Au@prussian blue nanoparticles as MR/SERS bimodal agents for dendritic cell activating and tracking

Cited by 33 publications

References 36 publications

Dual Functions of a Au@AgNP-Incorporated Nanocomposite Desalination Membrane with an Enhanced Antifouling Property and Fouling Detection Via Surface-Enhanced Raman Spectroscopy

Dual Functions of a Au@AgNP-Incorporated Nanocomposite Desalination Membrane with an Enhanced Antifouling Property and Fouling Detection Via Surface-Enhanced Raman Spectroscopy

Synthesis of Prussian Blue Nanoparticles and Their Antibacterial, Antiinflammation and Antitumor Applications

New advances on Au–magnetic organic hybrid core–shells in MRI, CT imaging, and drug delivery

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