Gadolinium-doped carbon dots with high quantum yield as an effective fluorescence and magnetic resonance bimodal imaging probe

Yu, Caiyan; Xuan, Tongtong; Chen, Yiwei; Zhao, Zhenjie; Liu, Huan; Lian, Guohai; Li, Huili

doi:10.1016/j.jallcom.2016.07.226

Cited by 101 publications

(72 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The recently developed Gd 3+ -based NPs such as Gd 2 O 3 -, 43-45,116 NaGdF 4 -, 36,38-41 GdF 3 -, 46,117,118 and Gd 3+ -doped NPs ( e.g ., quantum dots, 119-123 upconversion NPs, 124-126 and carbon dots 127,128 ) have been regarded as promising T 1 CAs because of their controllable size and morphology. By optimizing the reaction parameters during both nucleation and growth, Johnson et al .…”

Section: Factors Influencing Relaxivity Of Mri Contrast Agentsmentioning

confidence: 99%

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

et al. 2017

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) is a highly valuable non-invasive imaging tool owing to its exquisite soft tissue contrast, high spatial resolution, lack of ionizing radiation, and wide clinical applicability. Contrast agents (CAs) can be used to further enhance the sensitivity of MRI to obtain information-rich images. Recently, extensive research efforts have been focused on the design and synthesis of high-performance inorganic nanoparticle-based CAs to improve the quality and specificity of MRI. Herein, the basic rules, including the choice of metal ions, effect of electron motion on water relaxation, and involved mechanisms, of CAs for MRI have been elucidated in detail. In particular, various design principles, including size control, surface modification (e.g. organic ligand, silica shell, and inorganic nanolayers), and shape regulation, to impact relaxation of water molecules have been discussed in detail. Comprehensive understanding of how these factors work can guide the engineering of future inorganic nanoparticles with high relaxivity. Finally, we have summarized the currently available strategies and their mechanism for obtaining high-performance CAs and discussed the challenges and future developments of nanoparticulate CAs for clinical translation in MRI.

show abstract

Section: Factors Influencing Relaxivity Of Mri Contrast Agentsmentioning

confidence: 99%

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The O 1s spectrum (Figure c) is deconvoluted into two components corresponding to CO (531.4 eV) and CO (532.6 eV). The binding energy of 400.1 eV in the N 1s spectrum is attributed to CNN (Pan et al, ; Yu et al, ). The doping of N is derived from the existence of ethylenediamine in the reacting system.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the combination of carbon materials and Gd based compounds may result in dual‐functional agents for MRI guided PTT of cancer (Huang et al, ). For example, Gd(III)‐doped carbon dots have been proved to be promising as dual fluorescence‐MRI probes (Bourlinos et al, ; Pan et al, ; Yu et al, ), as well as imaging‐guided photodynamic therapy agent (Chen et al, ). For the MRI of lymph cancer particularly; however, there is special limitation in particle size of the contrast agents.…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging and photothermal conversion properties of Gd‐C nanocomposites for interstitial lymphography

et al. 2019

View full text Add to dashboard Cite

Dual‐functional agents for magnetic resonance imaging (MRI) guided photothermal therapy (PTT) of lymph cancer are highly desired. Signal enhancement, selectivity between lymphatic nodes/vessels and blood vessels, and photothermal conversion property are the criteria for such dual‐functional agent. In the current work, we demonstrated the potential of Gd‐C nanocomposites as dual‐functional agents for the MRI and PTT of lymph node cancer. Gd‐C nanocomposites were synthesized via a hydrothermal carbonization approach with gadolinium chloride as Gd source and citric acid (CA) as C source. The particle size of the nanocomposites ranges from 40 to 100 nm which is smaller than the intercellular space of lymphatic vessels but much larger than that of the blood vessels. The nanocomposites were successfully applied to the MRI of cervical lymph nodes of rabbits. The signal enhancement of the lymph nodes reached the maximum value of 434% at 10 min after injection, without displaying any blood vessel. The Gd‐C nanocomposites also exhibited strong photothermal conversion effect. Under the illumination of an 808 nm laser, the aqueous suspension containing 1.0 wt % Gd‐C nanocomposites gave a maximum temperature rise of 28.2 °C and a light utilization efficiency of 30.4%. The results indicate that Gd‐C nanocomposites have significant potential in MRI guided PTT of lymph cancer.

show abstract

“…A one-pot hydrothermal method was employed in order to obtain bio-imaging nanoprobes (~5.5 nm in size, nearly spherical) from citric acid, with high spatial resolution for MRI and enhanced fluorescence compared to that of carbon dots alone. 14 Nitrogen and sulfur co-doped carbon dots (N,S/CDs), 1.7 nm in size, with a high fluorescence quantum yield (39.7%) were obtained by Chen et al They posed low toxicity and good biocompatibility when co-incubated with HeLa cells. These types of doped CDs can be used to detect Cr (IV) by means of fluorescence quenching.…”

Section: Imagingmentioning

confidence: 99%

Quantum dots in imaging, drug delivery and sensor applications

Matea

Mocan

Tabaran

et al. 2017

IJN

526

231

View full text Add to dashboard Cite

Quantum dots (QDs), also known as nanoscale semiconductor crystals, are nanoparticles with unique optical and electronic properties such as bright and intensive fluorescence. Since most conventional organic label dyes do not offer the near-infrared (>650 nm) emission possibility, QDs, with their tunable optical properties, have gained a lot of interest. They possess characteristics such as good chemical and photo-stability, high quantum yield and size-tunable light emission. Different types of QDs can be excited with the same light wavelength, and their narrow emission bands can be detected simultaneously for multiple assays. There is an increasing interest in the development of nano-theranostics platforms for simultaneous sensing, imaging and therapy. QDs have great potential for such applications, with notable results already published in the fields of sensors, drug delivery and biomedical imaging. This review summarizes the latest developments available in literature regarding the use of QDs for medical applications.

show abstract

Gadolinium-doped carbon dots with high quantum yield as an effective fluorescence and magnetic resonance bimodal imaging probe

Cited by 101 publications

References 57 publications

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Magnetic resonance imaging and photothermal conversion properties of Gd‐C nanocomposites for interstitial lymphography

Quantum dots in imaging, drug delivery and sensor applications

Contact Info

Product

Resources

About