Gadolinium-DTPA in rheumatoid arthritis and related diseases: first results with dynamic magnetic resonance imaging

Reiser, Maximilian; Bongartz, G.; Erlemann, R.; Schneider, M; Pauly, Thomas H.; Sittek, H.; Peters, P. E.

doi:10.1007/bf00355334

Cited by 159 publications

(58 citation statements)

References 13 publications

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“…10,23,24 Yellow marrow usually shows less enhancement than red marrow 14 and it is generally recognised that fatty marrow has some of the lowest enhancement values amongst normal tissues. 25 The scaphoid lies peripherally in the appendicular skeleton and, in adults, its marrow is overwhelmingly fatty rather than haemopoeitic.…”

Section: Discussionmentioning

confidence: 99%

Scaphoid blood flow and acute fracture healing

Dawson¹,

Martel²,

Davis

2001

The Journal of Bone and Joint Surgery. British volume

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We have investigated whether assessment of blood flow to the proximal scaphoid can be used to predict nonunion in acute fractures of the scaphoid. We studied 32 fractures of the scaphoid one to two weeks after injury, by dynamic fat-suppressed T1-weighted gradient-echo MRI after the intravenous administration of gadopentetate dimeglumine (0.1 mmol/kg body-weight). Steepest slope values (SSV) and percentage enhancement values (%E) were calculated for the distal and proximal fragments and poles. All the fractures were treated by immobilisation in a cast, and union was assessed by CT at 12 weeks.Nonunion occurred in four fractures (12%), and there was no statistically significant difference between the proximal fragment SSV and %E values for the fractures which united and those with nonunion. The difference between the proximal pole SSV and %E values for the union and nonunion groups reached statistical significance (p < 0.05), but with higher enhancement parameters for the nonunion group. Our results suggest that poor proximal vascularity is not an important determinant of union in fractures of the scaphoid.

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Section: Discussionmentioning

confidence: 99%

Scaphoid blood flow and acute fracture healing

Dawson¹,

Martel²,

Davis

2001

The Journal of Bone and Joint Surgery. British volume

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“…The unique high soft tissue contrast on MR images can be further improved using gadolinium-based contrast agents to delineate inflamed synovial tissue and its relationship to joint effusion and neighbouring cartilage and bony structures [3,8,12]. Although MRI is considered to be inferior to X-radiography and/or CT in the detection of cortical destruction and endosteal/ periosteal reactions [11], it still may demonstrate bone changes not readily detectable by standard radiographic techniques [2,[5][6][7]10].…”

Section: Abstract: Magnetic Resonance Imaging -Rheumatoid Arthritis mentioning

confidence: 99%

“…The purpose of this study was to compare MRI with plain radiographs in order to evaluate the sensitivity of MRI in detecting bone destruction (marginal erosions and subchondral cysts) in a series of patients with known RA in whom one of the clinically active joints was the knee. In addition to standard MR examination, contrast-enhanced MR scans were used for qualitative assessment of the type of synovial invasion (inflammatory vs. fibrous) of the bone [3,8,12]. …”

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confidence: 99%

Magnetic resonance imaging of bone destruction in rheumatoid arthritis: comparison with radiography

et al. 1993

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Bony changes in forty-four knees of patients with clinically established rheumatoid arthritis (RA) were examined using magnetic resonance imaging (MRI) and plain film radiography. In all cases MRI was clearly superior to radiographs, demonstrating 25 marginal erosions and 42 subchondral cysts, while the number seen on radiographs was 3 and 8, respectively. These results emphasize the problems in visualizing bone erosions in large joints using plain films. MRI is the method of choice for detecting early changes in RA, not only because of its high sensitivity, but also because of the ability of contrast-enhanced MRI to provide physiological characterization of these lesions.

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“…In particular, MRI allowed differentiation of infl ammatory pannus from effusion in the knee joint when gadopentetate dimeglumin was applied for enhancement of the infl amed synovium/pannus formation [Reiser et al, 1989;König et al, 1990;Kursunoglu-Brahme et al, 1990].…”

Section: Imaging Findings In Patients With Arthritidesmentioning

confidence: 99%

Role of Magnetic Resonance Imaging in the Clinical Diagnosis of the Temporomandibular Joint

Larheim¹

2005

Cells Tissues Organs

165

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Temporomandibular joint (TMJ) abnormalities cannot be reliably assessed by a clinical examination. Magnetic resonance imaging (MRI) may depict joint abnormalities not seen with any other imaging method and thus is the best method to make a diagnostic assessment of the TMJ status. In patients with temporomandibular joint disorder (TMD) referred for diagnostic imaging the predominant TMJ finding is internal derangement related to disc displacement. This finding is significantly more frequent than in asymptomatic volunteers, and occurs in up to 80% of patients consecutively referred for TMJ imaging. Moreover, certain types of disc displacement seem to occur almost exclusively in TMD patients, namely complete disc displacements that do not reduce on mouth opening. Other intra-articular abnormalities may additionally be associated with the disc displacement, predominantly joint effusion (which means more fluid than seen in any asymptomatic volunteer) and mandibular condyle marrow abnormalities (which are not seen in volunteers). These conditions seem to be closely related. Nearly 15% of TMD patients consecutively referred for TMJ MRI will have joint effusion, of whom about 30% will show bone marrow abnormalities. In a surgically selected material of joints with histologically documented bone marrow abnormalities nearly 40% showed joint effusion. Disc displacement is mostly bilateral, but joint effusion seems to be unilateral or with a lesser amount of fluid in the contralateral joint. Abnormal bone marrow is also mostly unilateral. Many patients have unilateral pain or more pain on one side. In a regression analysis the self-reported in-patient TMJ pain side difference was positively dependent on TMJ effusion and condyle marrow abnormalities, but negatively dependent on cortical bone abnormalities. Of the joints with effusion only one fourth showed osteoarthritis. Thus, there seems to be a subgroup of TMD patients showing more severe intra-articular pathology than disc displacement alone, and mostly without osteoarthritis. It should, however, be emphasized that patients with TMJ effusion and/or abnormal bone marrow in the mandibular condyle seem to constitute only a minor portion (less than one fourth) of consecutive TMD patients referred for diagnostic TMJ imaging. The majority of patients have internal derangement related to disc displacement, but without accompanying joint abnormalities. In patients with rheumatoid arthritis and other arthritides TMJ involvement may mimick the more common TMDs. Using MRI it is possible, in most cases, to distinguish these patients from those without synovial proliferation.

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Gadolinium-DTPA in rheumatoid arthritis and related diseases: first results with dynamic magnetic resonance imaging

Cited by 159 publications

References 13 publications

Scaphoid blood flow and acute fracture healing

Scaphoid blood flow and acute fracture healing

Magnetic resonance imaging of bone destruction in rheumatoid arthritis: comparison with radiography

Role of Magnetic Resonance Imaging in the Clinical Diagnosis of the Temporomandibular Joint

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