Gadolinium (III) doped carbon dots as dual-mode sensor for the recognition of dopamine hydrochloride and glutamate enantiomers with logic gate operation

Wei, Shanshan; Liu, Baoqiang; Shi, Xinyuan; Cui, Shufeng; Zhang, Hongyuan; Lü, Pengju; Guo, Hui; Wang, Bin; Sun, Guoying; Jiang, Chunhuan

doi:10.1016/j.talanta.2022.123865

Cited by 15 publications

(7 citation statements)

References 58 publications

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“…Deflections do not affect the d spacing, which remains roughly 0.244 ± 0.013 nm (Figure a III ), indicating that the crystal lattice maintains a regular structure attributable to common nitrogen-containing CDs . To the best of our knowledge, most of the gadolinium-containing carbon dots reported in the literature have either amorphous or regular crystalline cores and carboxyl groups at the surface that coordinate Gd 3+ ions. , Besides, they do not display the peculiar lattice frame here observed, which therefore seems to be a unique feature of these hybrid CDs-Gd nanosystems. , It can be assumed that the structural defects observed are caused by the incorporation of Gd 3+ ions within the crystal lattice. Compared to other CDs reported in which Gd 3+ ions are chelated by surface carboxyl groups, the prevalent incorporation of Gd 3+ within the carbonaceous structure provides a huge advantage because ions are retained inside the CDs-Gd hybrids, thus avoiding toxic effects owing to uncontrolled release throughout the body …”

Section: Results and Discussionmentioning

confidence: 62%

“…38 To the best of our knowledge, most of the gadolinium-containing carbon dots reported in the literature have either amorphous or regular crystalline cores and carboxyl groups at the surface that coordinate Gd 3+ ions. 39,40 Besides, they do not display the peculiar lattice frame here observed, which therefore seems to be a unique feature of these hybrid CDs-Gd nanosystems. 41,42 It can be assumed that the structural defects observed are caused by the incorporation of Gd 3+ ions within the crystal lattice.…”

Section: Chemical Structural and Morphological Characterization Of Ga...mentioning

confidence: 64%

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Gadolinium-Doped Carbon Nanodots as Potential Anticancer Tools for Multimodal Image-Guided Photothermal Therapy and Tumor Monitoring

Mauro,

Cillari,

Gagliardo

et al. 2023

ACS Appl. Nano Mater.

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This study focuses on the synthesis and characterization of gadolinium-doped carbon nanodots (CDs-Gd) and their potential applications in multimodal imaging and precision cancer therapy. CDs-Gd were synthesized through a solvothermal decomposition method combining citric acid, GdCl 3 , and urea. The incorporation of Gd 3+ ions within the carbonaceous structure resulted in stable CDs-Gd with a peculiar architecture that retained optical and paramagnetic properties. Combined characterization techniques confirmed the presence of pH-sensitive COOH functions on the CDs-Gd surface along with the unique lattice structure induced by Gd 3+ doping. The optical properties of CDs-Gd exhibited a tunable emission spectrum displaying blue-green emission with pH-dependent behavior. Additionally, CDs-Gd exhibited contrast-enhancing properties in T 1 -weighted magnetic resonance imaging (MRI) experiments. MRI acquisitions at different Gd 3+ concentrations and pH values demonstrated the potential of CDs-Gd as contrast agents for monitoring pH changes in an aqueous environment. We found that the relaxivity of CDs-Gd at pH 5.5 (tumor, 11.3 mM −1 s −1 ) is roughly 3-fold higher than that observed at pH 7.4 (physiological, 5.0 mM −1 s −1 ) and outperformed clinical standards such as γ-butyrol (3.3 mM −1 s −1 ). Monitoring pH changes in tumor microenvironment (TME) is crucial for evaluating the effectiveness of anticancer treatments and understanding tumor progression. Furthermore, CDs-Gd demonstrated concentration-dependent photothermal conversion ability in the near-infrared (NIR) region, allowing for efficient heat generation under laser irradiation. This indicates the potential application of CDs-Gd in image-guided photothermal therapy (IG-PTT) for cancer treatment. The in vitro studies on MCF-7 (breast cancer) and 16-HBE (healthy bronchial epithelium) cell lines demonstrated that CDs-Gd exhibited high biocompatibility (cell viability >80%). However, upon NIR activation, they showed potent anticancer effects by inhibiting tumor cell proliferation and inducing apoptosis selectively in cancer cells. In conclusion, the synthesized CDs-Gd nanoparticles possess unique optical, photothermal, and MRI contrast properties, making them promising candidates for multimodal imaging-guided precision cancer therapy applications.

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Section: Results and Discussionmentioning

confidence: 62%

Section: Chemical Structural and Morphological Characterization Of Ga...mentioning

confidence: 64%

Gadolinium-Doped Carbon Nanodots as Potential Anticancer Tools for Multimodal Image-Guided Photothermal Therapy and Tumor Monitoring

Mauro,

Cillari,

Gagliardo

et al. 2023

ACS Appl. Nano Mater.

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“…Real samples of urine, human serum and energy drinks were analyzed for quantifying L-Lys and the corresponding recoveries, ranging from 86.19% to 109.65%, were considered satisfactory. Sun, Jiang and colleagues (Table 1, entry 2 [34]) obtained a dual-mode fluorescence/ colorimetric sensor with high sensitivity using gadolinium-(III)-doped CDs functionalized (non-covalently) with dopamine hydrochloride. In particular, Gd-(III)-doped CDs were synthesized by a top-down solvothermal method from a DMF solution of GdCl 3 and polyetherimide (PEI) and post-functionalized with dopamine hydrochloride (DH).…”

Section: Fluorescence and Colorimetric Chiral Sensorsmentioning

confidence: 99%

Carbon Dots in Enantioselective Sensing

Bortolami,

Curulli,

Di Matteo

et al. 2024

Sensors

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Chirality has a crucial effect on clinical, chemical and biological research since most bioactive compounds are chiral in the natural world. It is thus important to evaluate the enantiomeric ratio (or the enantiopurity) of the selected chiral analytes. To this purpose, fluorescence and electrochemical sensors, in which a chiral modifier is present, are reported in the literature. In this review, fluorescence and electrochemical sensors for enantiorecognition, in which chiral carbon dots (CDs) are used, are reported. Chiral CDs are a novel zero-dimensional carbon-based nanomaterial with a graphitic or amorphous carbon core and a chiral surface. They are nanoparticles with a high surface-to-volume ratio and good conductivity. Moreover, they have the advantages of good biocompatibility, multi-color emission, good conductivity and easy surface functionalization. Their exploitation in enantioselective sensing is the object of this review, in which several examples of fluorescent and electrochemical sensors, containing chiral CDs, are analyzed and discussed. A brief introduction to the most common synthetic procedures of chiral CDs is also reported, evidencing strengths and weaknesses. Finally, consideration concerning the potential challenges and future opportunities for the application of chiral CDs to the enantioselective sensing world are outlined.

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“…The peaks at 2924 cm À1 and 1384 cm À1 were attributed to the C-H anti-symmetric stretching vibration and bending vibration. 34 The bands at 1660 cm À1 and 1300 cm À1 derived from the CQO and C-N stretching vibration, indicating the existence of -CONH-bonds in both Ce-Gd@CDs and Ce-Gd@CDs-GOx nanozymes. These hydrophilic functional groups were beneficial to improve the water solubility of nanozymes.…”

Section: Preparation and Characterization Of Ce-gd@cds And Ce-gd@cds-...mentioning

confidence: 99%

A double rare earth doped CD nanoplatform for nanocatalytic/starving-like synergistic therapy with GSH-depletion and enhanced reactive oxygen species generation

et al. 2023

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Gadolinium (III) doped carbon dots as dual-mode sensor for the recognition of dopamine hydrochloride and glutamate enantiomers with logic gate operation

Cited by 15 publications

References 58 publications

Gadolinium-Doped Carbon Nanodots as Potential Anticancer Tools for Multimodal Image-Guided Photothermal Therapy and Tumor Monitoring

Gadolinium-Doped Carbon Nanodots as Potential Anticancer Tools for Multimodal Image-Guided Photothermal Therapy and Tumor Monitoring

Carbon Dots in Enantioselective Sensing

A double rare earth doped CD nanoplatform for nanocatalytic/starving-like synergistic therapy with GSH-depletion and enhanced reactive oxygen species generation

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