Gadolinium silicate-coated porous silicon nanoparticles as an MRI contrast agent and drug delivery carrier

Jin, Ji Hye; Um, Hye Ji; Oh, Jung Hyub; Huh, Youngbuhm; Jung, Yuna; Kim, Dokyoung

doi:10.1016/j.matchemphys.2022.126345

Cited by 11 publications

(7 citation statements)

References 37 publications

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“…In a study that aimed to synthesize and characterize FeGdPt NPs, Chou et al [58] found that FeGdPt NPs have feasible applications in dual-modal MRI (T 1 /T 2 ) and CT imaging. More recent evidence [59] shows that coated porous silicon NPs (pSiNPs) with gadolinium ions (Gd 3+ ) can be used as an MRI contrast agent. They point out that pSiNPs-Gd showed high drug encapsulation efficacy and T 1 -weighted MR image contrast agent performance.…”

Section: Gadolinium-based Nanoparticlesmentioning

confidence: 99%

Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

2023

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In recent years, there has been an increasing interest in using nanoparticles in the medical sciences. Today, metal nanoparticles have many applications in medicine for tumor visualization, drug delivery, and early diagnosis, with different modalities such as X-ray imaging, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), etc., and treatment with radiation. This paper reviews recent findings of recent metal nanotheranostics in medical imaging and therapy. The study offers some critical insights into using different types of metal nanoparticles in medicine for cancer detection and treatment purposes. The data of this review study were gathered from multiple scientific citation websites such as Google Scholar, PubMed, Scopus, and Web of Science up through the end of January 2023. In the literature, many metal nanoparticles are used for medical applications. However, due to their high abundance, low price, and high performance for visualization and treatment, nanoparticles such as gold, bismuth, tungsten, tantalum, ytterbium, gadolinium, silver, iron, platinum, and lead have been investigated in this review study. This paper has highlighted the importance of gold, gadolinium, and iron-based metal nanoparticles in different forms for tumor visualization and treatment in medical applications due to their ease of functionalization, low toxicity, and superior biocompatibility.

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Section: Gadolinium-based Nanoparticlesmentioning

confidence: 99%

Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

2023

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“…The physiochemical properties of metal nanoparticles for specific functions play a vital role for metal NPs to act as theranostic probes for disease diagnosis and therapy. , The metal NPs have been engineered in various ways to use it for theranostic applications. The size and structural tuning of metal nanoparticles are being altered by varying synthesis conditions to obtain unique physicochemical properties for a wide range of applications. , The widely studied water-soluble Au 25 (SR) 18 metal clusters have remarkable difference in sizes and structures leading to interesting properties and functions for theranostic applications . The composition of metal NPs and their composite also affects the physicochemical properties. , In addition, the metallic NPs can also be engineered to regulate the biocompatibility and biological interactions of the material. , Water-soluble molecules such as γ-glutathione (GSH), cysteine (Cys), 6-mercaptohexanoic acid (MHA), mercaptobenzoic acid (MBA), and dihydrolipoic acid (DHLA) have been used as ligand shells of metal NCs.…”

Section: Nanoparticles Used For Theranostic Purposesmentioning

confidence: 99%

“…The size and structural tuning of metal nanoparticles are being altered by varying synthesis conditions to obtain unique physicochemical properties for a wide range of applications. 101,102 The widely studied water-soluble Au 25 (SR) 18 metal clusters have remarkable difference in sizes and structures leading to interesting properties and functions for theranostic applications. 103 The composition of metal NPs and their composite also affects the physicochemical properties.…”

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confidence: 99%

Nanomaterials as Theranostic Agents for Cancer Therapy

Bauri,

Tripathi,

Choudhury

et al. 2023

ACS Appl. Nano Mater.

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“…The most commonly used nanoparticles are silver, gold, gadolinium, and iron. [10][11][12][13] Thanks to the magnetic properties of certain elements, the possibility of using these nanoparticles in different fields is increasing. For example, magnetic nanoparticles are used as contrast agents (CA) for MRI imaging to increase the contrast and to reduce the time of analysis.…”

Section: Introductionmentioning

confidence: 99%

One Step Superparamagnetic Iron Oxide Nanoparticles by a Microwave Process: Optimization of Microwave Parameters with an Experimental Design

Girardet,

Kessler,

Migot

et al. 2024

Part & Part Syst Charact

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Superparamagnetic iron oxide nanoparticles (SPIONs) are nanoparticles used in a lot of applications such as batteries, and biomedical, … To obtain these nanoparticles, several techniques exist such as coprecipitation, thermal decomposition, sol–gel process but they have some advantages (synthesis in a water media, high crystallinity, high monodispersity) and disadvantages (using an organic solvent, large distribution of size, poor crystallinity). The goal of this work is to synthesize SPIONs for biomedical applications (for example as a contrast agent for the MRI): SPIONs should be stable in an aqueous media, monodisperse, and have good crystallinity and magnetic properties. To achieve this result, a microwave process is carried out. However, any study describes the microwave parameter on the synthesis of the nanoparticles. This work offers to determine the best conditions of the microwave to obtain ideal SPIONs for MRI. For this, an experimental design is carried out to determine these parameters thanks to different techniques of characterization (Transmission Electronic Microscopy, Dynamic Light Scattering, X‐ray diffraction, Thermogravimetric Analysis, magnetic characterizations). With the different results of these characterizations, the best conditions of the microwave are determined, and a simulation of all experiments is realized with a surface response.

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Gadolinium silicate-coated porous silicon nanoparticles as an MRI contrast agent and drug delivery carrier

Cited by 11 publications

References 37 publications

Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

Nanomaterials as Theranostic Agents for Cancer Therapy

One Step Superparamagnetic Iron Oxide Nanoparticles by a Microwave Process: Optimization of Microwave Parameters with an Experimental Design

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