Gain-Based Mechanism for 
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 Sensing Based on Random Lasing

Gaio, Michele; Caixeiro, Soraya; Marelli, Benedetto; Omenetto, Fiorenzo G.; Sapienza, Riccardo

doi:10.1103/physrevapplied.7.034005

Cited by 49 publications

(19 citation statements)

References 39 publications

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“…As the diameter of voids is decreased, the ASE threshold tends to decrease and the number of RL spots increases, indicating that random cavities with high-Q factors arise because of the shortened scatterers. It is noteworthy that we observed no RL behavior at the 1-μm SIO for which refs 24,25 reported gain enhancement, but RLs were obtained even when the diameter was reduced to 100 nm (Supplementary Fig. 5).…”

Section: Resultsmentioning

confidence: 59%

“…The third harmonic of a pulsed neodymium-doped yttrium aluminum garnet (Nd:YAG) laser at 355 nm (pulse duration of 25 ps and repetition ratio of 2 Hz) pumped the dye-doped silk film and the SIO to exhibit ASE and RL. In refs 24,25 , the authors claim that the spectra were obtained from similar structures to our SIO show RL and that they engineered the first silk-based biocompatible RL However, the narrowed spectral peak above threshold with about 10-nm full width at half maximum (FWHM) just indicated the transition to the ASE from the photoluminescence (PL, the fluorescence of a dye). Further, we confirmed that our bulk silk/dye film with no micro/nanostructures exhibited the same spectral behaviors as those reported in refs 24,25 .…”

Section: Resultsmentioning

confidence: 73%

“…In refs 24,25 , the authors claim that the spectra were obtained from similar structures to our SIO show RL and that they engineered the first silk-based biocompatible RL However, the narrowed spectral peak above threshold with about 10-nm full width at half maximum (FWHM) just indicated the transition to the ASE from the photoluminescence (PL, the fluorescence of a dye). Further, we confirmed that our bulk silk/dye film with no micro/nanostructures exhibited the same spectral behaviors as those reported in refs 24,25 . Our investigation revealed that the incorporation of micro/nanoscatterers could reduce the threshold of ASE, and the real RL could arise when the inhomogeneity of the RI distribution yielded a high-Q random cavity.

Figure 1RL and ASE using the silk protein opal.…”

Section: Resultsmentioning

confidence: 73%

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Random lasing and amplified spontaneous emission from silk inverse opals: Optical gain enhancement via protein scatterers

Umar

Min

Kim

et al. 2019

Sci Rep

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Gain amplification and coherent lasing lines through random lasing (RL) can be produced by a random distribution of scatterers in a gain medium. If these amplified light sources can be seamlessly integrated into biological systems, they can have useful bio-optical applications, such as highly accurate sensing and high-resolution imaging. In this paper, a fully biocompatible light source showing RL and amplified spontaneous emission (ASE) with a reduced threshold is reported. Random cavities were induced in a biocompatible silk protein film by incorporating an inverse opal with an inherent disorder and a biocompatible dye for optical gain into the film. By choosing the appropriate air-sphere diameters, clear RL spikes in the emission spectra that were clearly distinguished from those of the ASE were observed in the silk inverse opal (SIO) with optical gain. Additionally, the RL output exhibited spatial coherence; however, the ASE did not. The high surface-to-volume ratio and amplification of the SIO led to highly efficient chemosensing in the detection of hydrogen chloride vapor. Moreover, SIO could be miniaturized to be made suitable for injection into biological tissues and obtain RL signals. Our results, which open the way for the development of a new generation of miniaturized bio-lasers, may be considered as the first example of engineered RL with biocompatible materials.

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Section: Resultsmentioning

confidence: 59%

Section: Resultsmentioning

confidence: 73%

Figure 1RL and ASE using the silk protein opal.…”

Section: Resultsmentioning

confidence: 73%

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Random lasing and amplified spontaneous emission from silk inverse opals: Optical gain enhancement via protein scatterers

Umar

Min

Kim

et al. 2019

Sci Rep

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“…The spectral characteristics of the laser emission are strongly dependent on the scattering properties of the medium, providing new tools to investigate disordered biological materials. To date, random lasers have shown the feasibility to detect physical changes or chemical changes within biological materials . Figure a shows the sensing mechanism of a random laser, by using pH sensing as an example.…”

Section: Biological and Biomedical Sensingmentioning

confidence: 99%

“…Narrow linewidth (lasing) is observed when the pH value is neutral, while broad fluorescence emission is observed when it has alkaline pH values. Adapted with permission . Copyright 2017, American Physical Society.…”

Section: Biological and Biomedical Sensingmentioning

confidence: 99%

Biological Lasers for Biomedical Applications

Chen

Fan

2019

Advanced Optical Materials

125

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A biolaser utilizes biological materials as part of its gain medium and/or part of its cavity. It can also be a micro‐ or nanosized laser embedded/integrated within biological materials. The biolaser employs lasing emission rather than regular fluorescence as the sensing signal and therefore has a number of unique advantages that can be explored for broad applications in biosensing, labeling, tracking, contrast agent development, and bioimaging. This article reports on the progress in biolasers with focus on the work done in the past five years. In the end, the possible future directions of the biolaser are discussed.

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Random Laser Spectral Fingerprinting of Lithographed Microstructures

Capocefalo

Quintiero

Bianco

et al. 2021

Adv Materials Technologies

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Coherent random lasers (RLs) originate from the resonant amplification of the light scattered by disordered media resulting in spiky emission spectra with well‐defined spectral signatures. Here coherent RL emission is proposed as a tool for identifying the spectral fingerprint of porous micro‐structured materials obtained by soft lithography techniques. The close control of the spatial patterns and structural characteristics of the scattering elements enable us to obtain stable and unique RL spectra distinctive of each lithographed device. The spectral emission has been thoroughly analyzed with respect to the morphology of the devices in terms of surface roughness and surface volume fraction, demonstrating that the packing of the scattering particles is the main factor in determining a RL emission characterized by multiple linewidths with a high level of coherence. The findings provide novel insights for the realization of miniaturized photonic devices with selectable optical features.

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Gain-Based Mechanism for pH Sensing Based on Random Lasing

Cited by 49 publications

References 39 publications

Random lasing and amplified spontaneous emission from silk inverse opals: Optical gain enhancement via protein scatterers

Random lasing and amplified spontaneous emission from silk inverse opals: Optical gain enhancement via protein scatterers

Biological Lasers for Biomedical Applications

Random Laser Spectral Fingerprinting of Lithographed Microstructures

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