Gain of survival signaling by down-regulation of three key miRNAs in brain of calorie-restricted mice

Khanna, Amit; Muthusamy, Senthilkumar; Liang, Ruqiang; Sarojini, Harshini; Wang, Eugenia

doi:10.18632/aging.100276

Cited by 118 publications

(92 citation statements)

References 32 publications

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“…A recent report shows a decrease in expression of three miRNAs (miR-181a-1-5p, miR-30e and miR-34a) following CR in the brains of aged mice. 25 All three miRNAs are shown to target translation of the Bcl-2 mRNA, demonstrating the potential for orchestrated actions of CR-mediated differentially expression of miRNAs.…”

Section: Methodsmentioning

confidence: 92%

MicroRNA-203 regulates caveolin-1 in breast tissue during caloric restriction

et al. 2012

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Caloric restriction has been shown to increase lifespan in several organisms and to delay onset of age-related diseases. The transcriptional response to caloric restriction has been studied for mRnAs, while the microRnA signature following caloric restriction remains unexplored. here, we characterize the microRnA expression in mouse breast tissue before and after caloric restriction, reporting several changes in the microRnA expression profile. In particular, miR-203 is found to be highly induced by caloric restriction, and we demonstrate that caveolin-1 as well as p63 are direct targets of miR-203 in vivo during caloric restriction. Using tissue culture models, we suggest that this regulation is important in both mouse and human. In conclusion, we show that the microRnA response induced by caloric restriction can regulate important factors in processes such as longevity and aging and is an integral and important component of the cellular response to caloric restriction.Caloric restriction (CR) has been shown to have a positive effect on life span across several organisms [1][2][3] and is speculated to be beneficial for the treatment of age-related diseases. Delineating the genetic response to CR is crucial to understand these effects on aging and disease and specifically in breast tissue since CR has been shown to have potential therapeutic benefit in diseases of the breast. 4,5

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Section: Methodsmentioning

confidence: 92%

MicroRNA-203 regulates caveolin-1 in breast tissue during caloric restriction

et al. 2012

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“…The Bcl-2 protein resides in the outer mitochondrial wall, and acts as an anti-apoptotic factor by controlling mitochondrial permeability, thus regulating apoptosis [47]. Previous evidence of miRNA impact on cell survival mechanisms has been shown with miR-15, miR-16, miR-34a and miR-181a-1* targeting Bcl-2 mRNA and inducing apoptosis [48] [49]. Here from 10 months old to 20 months old ageing process, miR-15b, miR-195, miR-30c, miR-23a, miR-23b, miR-125a-5p, miR-125b-5p, miR-34c may bind with Bcl2 mRNA to participate in the regulation of apoptosis signal pathway (Table 3, Figure 5(C)).…”

Section: Discussionmentioning

confidence: 99%

Microarray Analysis of microRNAs Expression Profiles in Adult and Aged Mice Hippocampus

Jia¹,

Liu²,

Yu³

et al. 2017

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Purpose: To analyze the miRNA expression profiles in C57 mice ageing hippocampus in detail, and investigate the functional information of these hippocampus specific miRNAs and the related regulatory networks. Methods: Microarrays were used to analyze miRNA expression profiles in adult and aged hippocampi, and bioinformatics analysis methods, such as three public datasets (Mirbase, Miranda, and Mirdb), DAVID online tools and KEGG pathway tools were used to study in detail the target genes of the differentially expressed miRNAs. Results: 26 differentially expressed miRNAs were identified by greater than 1.5-fold change (intersection of two sets), of which 16 were up-regulated and 10 were down-regulated. DAVID Functional Annotation Cluster (FAC) analysis of the 132 predicted target genes of up-regulated miRNAs revealed confident enrichment scores for synaptic function and apoptosis etc. (Figure 1), indicating the functional significance and importance of these miRNAs during hippocampal ageing. Conclusions: Bioinformatic analyses of the differentially expressed miRNAs have identified a number of miRNAs with putative involvement in the hippocampus ageing process. This study lays a solid foundation for further studies to clarify the important regulation function of miRNAs in ageing process of brain tissue.

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“…Moreover, miR-92a was slightly down-regulated in the sera of SZ patients in comparison to controls [44]. Finally, down-regulation of miR-30 may be important for neuronal survival [45].…”

mentioning

confidence: 87%

Deregulated microRNA expression in biospecimens from patients diagnosed with schizophrenia and bipolar disorder as a disease biomarker

Delalle

Kao

Choi

2014

Translational Neuroscience

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The biological markers for schizophrenia (SZ) and bipolar disorder (BD) would represent a precious tool in evaluating the risk for the development of these common neuropsychiatric diseases and, possibly, in the prevention of either disease episodes and/or treatment efficiency monitoring. Since both SZ and BD are diseases with a significant genetic component, the research over the last decades has focused on the genes with altered function in the central nervous system (CNS) of individuals suffering from these illnesses. Recently, however, small non-coding RNA molecules (microRNAs, miRNAs, miRs) were shown to regulate the expression of human CNS genes involved in cell processes and functions negatively affected in neuropsychiatric disorders, including synaptic development and maturation, learning and memory. Differentially expressed sets of miRNAs have been reported in the tissues of SZ and BD patients in comparison to controls suggesting the emergence of a novel class of potential biomarkers. Here we review the reports on the changes in miRNA expression in postmortem brain tissue and peripheral blood in SZ and BD. We also evaluate the potential of miRNA packaged in exosomes, signaling vesicles released by neurons and glia, to contribute to the disaggregation of the molecular machinery underlying mental disorders and provide clinically useful biomarkers.

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Gain of survival signaling by down-regulation of three key miRNAs in brain of calorie-restricted mice

Cited by 118 publications

References 32 publications

MicroRNA-203 regulates caveolin-1 in breast tissue during caloric restriction

MicroRNA-203 regulates caveolin-1 in breast tissue during caloric restriction

Microarray Analysis of microRNAs Expression Profiles in Adult and Aged Mice Hippocampus

Deregulated microRNA expression in biospecimens from patients diagnosed with schizophrenia and bipolar disorder as a disease biomarker

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