2022
DOI: 10.1111/hae.14544
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Gaining more insight into ankle pain in haemophilia: A study exploring pain, structural and functional evaluation of the ankle joint

Abstract: Introduction Ankle arthropathy is highly prevalent among people with haemophilia (PwH), even with prophylaxis, and leads to pain and disability. Mechanisms and consequences of painful symptoms related to ankle arthropathy have not been extensively studied. Methods A consecutive sample of 30 adult PwH was included (60 ankles). Ankle structure was assessed with magnetic resonance imaging (IPSG‐MRI) and ultrasound (HEAD‐US). The HJHS 2.1 assessed function of ankles and knees. Physical functioning was assessed wit… Show more

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Cited by 13 publications
(26 citation statements)
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References 45 publications
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“…In other joint conditions, studies revealed a lack of association between joint pain and structural damage 4,5 . Nevertheless, only few studies investigated this association in PwH 6 . Nowadays, the ankle remains the most painful and invalidating joint in PwH, 7 therefore investigating this particular joint is of relevance.…”
Section: Introductionmentioning
confidence: 99%
“…In other joint conditions, studies revealed a lack of association between joint pain and structural damage 4,5 . Nevertheless, only few studies investigated this association in PwH 6 . Nowadays, the ankle remains the most painful and invalidating joint in PwH, 7 therefore investigating this particular joint is of relevance.…”
Section: Introductionmentioning
confidence: 99%
“…A time window > 24 h between physical examination and ultrasound assessment introduced a high risk of bias in the ‘flow and timing’ domain in three studies 11,40,47 . Three studies scored ‘high risk of bias’ in the latter domain because examinations were not performed in all eligible joints 41,44 or not all data from the examined joints was available for analysis 12 …”
Section: Resultsmentioning
confidence: 99%
“…The reasons for excluding studies based on full text are summarized in Supplement S2. Eventually, 15 studies 11,12,15,24,29,[38][39][40][41][42][43][44][45][46][47] were included in the systematic review. The 15 included studies reported on occurrence of swelling and synovial proliferation in 2890 joints of 627 patients.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Recurrent joint bleedings result in chronic pain, which is more complicated than acute pain and adversely affects PWH. The underlying mechanism of pain in hemophilia remains to be elucidated [ 11 , 30 , 107 , 108 , 109 , 110 ]. Based on other chronic pain conditions with joint pain such as osteoarthritis (OA) or rheumatoid arthritis (RA), the possible mechanisms may include features of nociceptive and/or neuropathic pain [ 111 , 112 ].…”
Section: Oxidative Stress As a Contributor To Pain In Hemophiliamentioning
confidence: 99%