Gains and Losses: Resilience to Social Defeat Stress in Adolescent Female Mice

Pantoja-Urbán, Andrea Harée; Richer, Samuel; Mittermaier, Amelie; Giroux, Michel; Nouel, Dominique; Hernández, Giovanni; Flores, Cecilia

doi:10.1016/j.biopsych.2023.06.014

Cited by 8 publications

(1 citation statement)

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“…While this may seem contradictory to previous work, few studies exploring the effects of post-weaning social isolation stress have tested the animal's social interaction behavior during the adolescent time point. Further this is consistent with work demonstrating increased "resilience" to stress during adolescence can manifest as alterations later in adulthood [29].…”

Section: Post-weaning Social Isolation Stress Does Not Impact Social ...supporting

confidence: 90%

Post-weaning social isolation alters sociability in a sex-specific manner

Myers,

Birmingham,

Rhoads

et al. 2024

Preprint

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Adolescence is a critical period for brain development in humans and stress exposure during this time can have lasting effects on behavior and brain development. Social isolation and loneliness are particularly salient stressors that lead to detrimental mental health outcomes particularly in females, although most of the preclinical work on social isolation has been done in male animals. Our lab has developed a model of post-weaning adolescent social isolation that leads to increased drug reward sensitivity and altered neuronal structure in limbic brain regions. The current study utilized this model to determine the impact of adolescent social isolation on a three-chamber social interaction task both during adolescence and adulthood. We found that while post-weaning isolation does not alter social interaction during adolescence (PND45), it has sex-specific effects on social interaction in adulthood (PND60), potentiating social interaction in male mice and decreasing it in female mice. As early life stress can activate microglia leading to alterations in neuronal pruning, we next examined the impact of inhibiting microglial activation with daily minocycline administration during the first three weeks of social isolation on these changes in social interaction. During adolescence, minocycline dampened social interaction in male mice, while having no effect in females. In contrast, during adulthood, minocycline did not alter the impact of adolescent social isolation in males, with socially isolated males exhibiting higher levels of social interaction compared to their group housed counterparts. In females, adolescent minocycline treatment reversed the effect of social isolation leading to increased social interaction in the social isolation group, mimicking what is seen in naïve males. Taken together, adolescent social isolation leads to sex-specific effects on social interaction in adulthood and adolescent minocycline treatment alters the effects of social isolation in females, but not males.

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Section: Post-weaning Social Isolation Stress Does Not Impact Social ...supporting

confidence: 90%