Gait analysis with videogrammetry can differentiate healthy elderly, mild cognitive impairment, and Alzheimer's disease: A cross-sectional study

Silva, Felipe de Oliveira; Ferreira, José Vinícius; Plácido, Jéssica; Chagas, Daniel das Virgens; Praxedes, Jomilto; Guimarães, Carla P.; Batista, Luiz Alberto; Laks, Jérson; Deslandes, Andréa Camaz

doi:10.1016/j.exger.2019.110816

Cited by 21 publications

(16 citation statements)

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“…Although there is a clear relationship between human movement and mental health, the use of motor assessment in clinical evaluation is still rare ( Deschamps, 2018 ). In neurocognitive disorders, gait parameters ( de Oliveira Silva et al, 2019a ), dual-task ( Ferreira et al, 2019 ), handgrip strength ( Teixeira et al, 2019 ), and spatial navigation ( Zanco et al, 2018 ) have been investigated to differentiate healthy older adults, MCI and AD, as well as different stages of Dementia ( de Oliveira Silva et al, 2019b ; Placido et al, 2019 ). However, our results showed a reduced ES magnitude in motor tests, compared to cognitive and cognitive-motor parameters for distinguishing groups according to functionality.…”

Section: Discussionmentioning

confidence: 99%

Spatial navigation and dual-task performance in patients with Dementia that present partial dependence in instrumental activity of daily living

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Spatial navigation and dual-task performance in patients with Dementia that present partial dependence in instrumental activity of daily living

et al. 2020

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“…Based on these theories, DT tests have been widely used to study the cognitive-motor interference and the risk of falls in different populations, such as patients with stroke, Alzheimer's disease, Parkinson's disease, or multiple sclerosis (Mofateh et al, 2017 ; Feld et al, 2018 ; de Oliveira Silva et al, 2020 ; Penko et al, 2020 ). Some studies found that old people had greater DT costs compared to young adults, and this deficit was related to the high incidence of falls in the elderly (Lindenberger et al, 2000 ; Bock, 2008 ; Pothier et al, 2015 ; Papegaaij et al, 2017 ; Uematsu et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Cerebral Microbleeds Were Related With Poor Cognitive Performances on the Dual Task Condition in Older Adults

Yang

Qin

et al. 2022

Front. Aging Neurosci.

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Background: The dual task (DT) was commonly used to assess the risk of falls in older adults and patients with neurological disorders. However, the performance on DT conditions has not been well investigated in patients with cerebral microbleed (CMB). This study is aimed to compare the performance in DT tests between older adults with and without CMB, and to explore the association between CMB and cognitive performances of DT.Methods: This is a cross-sectional study. A total of 211 old adults participated, involving 68 CMB patients. The task protocol involved two global cognition tests, two single cognitive tests (serial 7 subtraction and semantic fluency), two single motor tasks [8-m walking and timed up and go test (TUG)], and three DT tests [walking and serial subtraction (WSS), walking and semantic fluency (WSF), and TUG and serial subtraction (TUGSS)]. The time taken to complete each task and the number of correct responses were recorded. For each DT condition, the correct response rate (CRR) and the dual-task effect (DTE) for the correct number were calculated.Results: Compared with subjects without CMB, CMB patients had worse cognitive performances on DT condition in CRR of WSS (p = 0.003), WSF (p = 0.030) and TUGSS (p = 0.006), and DTE of WSS (p = 0.017). Binary logistic regression analysis showed that the presence of CMB was an independent risk factor for the impairment group for CRR of TUGSS (OR, 2.54; 95% CI, 1.11–5.82; p = 0.027) with the adjustment for confounders, rather than CRR of WSS and WSF, or DTE of WSS. Multiple linear regression analysis showed that CRR of TUGSS decreased with the increase of CMB number grades (β, −0.144; 95% CI, −0.027, −0.002; p = 0.028).Conclusion: The present study indicated that CMBs were closely associated with poor cognitive performances on DT in the elderly. Strongest effect size was seen for CRR of TUGSS, where performance deficits increased in proportion to the degree of CMB burden.

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“…However, at high concentrations, RSV acts as a pro-oxidant and promotes cellular damage [ 4 ]. The optimal RSV dosage for maximizing the benefit of RSV to cardiovascular health without increasing toxicity requires further investigation [ 126 ].…”

Section: Potential Adverse Effects Of Rsvmentioning

confidence: 99%

Influence of Resveratrol on the Cardiovascular Health Effects of Chronic Kidney Disease

Song

Shen

Hou

et al. 2020

IJMS

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Cardiovascular disease (CVD) is closely related to chronic kidney disease (CKD), and patients with CKD have a high risk of CVD-related mortality. Traditional CVD risk factors cannot account for the higher cardiovascular risk of patients with CKD, and standard CVD interventions cannot reduce the mortality rates among patients with CKD. Nontraditional factors related to mineral and vitamin-D metabolic disorders provide some explanation for the increased CVD risk. Non-dialyzable toxins, indoxyl sulfate (IS) and p-cresol sulfate (PCS)—produced in the liver by colonic microorganisms—cause kidney and vascular dysfunction. Plasma trimethylamine-N-oxide (TMAO)—a gut microbe-dependent metabolite of dietary L-carnitine and choline—is elevated in CKD and related to vascular disease, resulting in poorer long-term survival. Therefore, the modulation of colonic flora can improve prospects for patients with CKD. Managing metabolic syndrome, anemia, and abnormal mineral metabolism is recommended for the prevention of CVD in patients with CKD. Considering nontraditional risk factors, the use of resveratrol (RSV), a nutraceutical, can be helpful for patients with CVD and CKD. This paper discusses the beneficial effects of RSV on biologic, pathophysiological and clinical responses, including improvements in intestinal epithelial integrity, modulation of the intestinal microbiota and reduction in hepatic synthesis of IS, PCS and TMAO in patients with CVD and CKD.

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Gait analysis with videogrammetry can differentiate healthy elderly, mild cognitive impairment, and Alzheimer's disease: A cross-sectional study

Cited by 21 publications

References 51 publications

Spatial navigation and dual-task performance in patients with Dementia that present partial dependence in instrumental activity of daily living

Spatial navigation and dual-task performance in patients with Dementia that present partial dependence in instrumental activity of daily living

Cerebral Microbleeds Were Related With Poor Cognitive Performances on the Dual Task Condition in Older Adults

Influence of Resveratrol on the Cardiovascular Health Effects of Chronic Kidney Disease

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