Gait Disturbances are Associated with Increased Cognitive Impairment and Cerebrospinal Fluid Tau Levels in a Memory Clinic Cohort

Muurling, Marijn; Rhodius-Meester, Hanneke F.M.; Pärkkä, Juha; Gils, Mark van; Frederiksen, Kristian Steen; Bruun, Marie; Hasselbalch, Steen G.; Herukka, Sanna Kaisa; Hallikainen, Merja; Teunissen, Charlotte E.; Visser, Pieter Jelle; Scheltens, Philip; Flier, Wiesje M. van der; Mattila, Jussi; Lötjönen, Jyrki; Boer, Casper de

doi:10.3233/jad-200225

Cited by 16 publications

(33 citation statements)

References 37 publications

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“…The participants were older people aged 60 years and older (average age 71.4) who did not require assistance to perform motor or cognitive tests. The initial cognitive state of the participants included: 25.0% (3 studies) only "with MCI" (Gillain et al, 2016;Montero-Odasso et al, 2017;Åhman et al, 2020a); 25.0% (3 studies) "without dementia" (Beauchet et al, 2017;Ceïde et al, 2018;Donoghue et al, 2018); 16.7% (2 studies) "without cognitive impairment" (Rosso et al, 2019;Osuka et al, 2020a); and 33.3% (4 studies) "cognitively healthy" (CH) people and with "some degree of cognitive impairment" (Deshpande et al, 2009;Nielsen et al, 2018;De Cock et al, 2019;Muurling et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

Dual-Task Gait as a Predictive Tool for Cognitive Impairment in Older Adults: A Systematic Review

Ramírez

Gutiérrez

2021

Front. Aging Neurosci.

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The use of the dual-task model as a cognitive-motor interface has been extensively investigated in cross-sectional studies as a training task in cognitive impairment. However, few existing longitudinal studies prove the usefulness of this tool as a clinical marker of cognitive impairment in older people. What is the evidence in prospective studies about dual-task gait as a predictor of cognitive impairment in older adults? This study aims to review and discuss the current state of knowledge in prospective studies on the use of dual-task gait as a predictive tool for cognitive impairment in older adults. The methodology used was a systematic review, according to the PRISMA criteria for the search, summarize and report. A search in 3 databases (Pubmed, Web of Science, and Scopus) was carried out until April 2021. The search terms used were: “(gait OR walking) AND (cognitive decline) AND (dual-task) AND (follow-up OR longitudinal OR long-term OR prospective OR cohort OR predict).” We included prospective research articles with older people with cognitive evaluation at the beginning and the end of the follow-up and dual-task gait paradigm as initial evaluation associated with the presentation of cognitive impairment prediction using any dual-task gait parameters. After exclusion criteria, 12 studies were reviewed. The results indicate that eight studies consider dual-task gait parameters a useful cognitive-motor tool, finding that some of the evaluated parameters of dual-task gait significantly correlate with cognitive impairment over time. The most promising DT parameters associated with cognitive impairment prediction seem to be gait speed, speed cost, DT time, numbers of words during DT, among others. In sum, this study reviews the variety of dual-task gait parameters and their relevance as a simple tool for early cognitive impairment screening, opening a diagnostic window for the screening of cognitive impairment in older people.

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Section: Resultsmentioning

confidence: 99%

Dual-Task Gait as a Predictive Tool for Cognitive Impairment in Older Adults: A Systematic Review

Ramírez

Gutiérrez

2021

Front. Aging Neurosci.

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“…Pathologic tau also has been linked to gait disturbance (Muurling et al, 2020), but additional studies are needed to fully understand the connections between tauopathies and gait dysfunction . Like humans, slow gait in vervets was associated with lower CSF Aβ 1-42 and higher brain concentrations of Aβ 1-42 (Latimer et al, 2019).…”

Section: Neuropathologic Changes and Physical Declinementioning

confidence: 99%

“…In adults aged 50–69 years, slow gait was associated with PET measures of Aβ accumulation in multiple brain regions, particularly the temporal lobe (Wennberg, Savica & Hagen, Roberts, et al, 2017). Pathologic tau also has been linked to gait disturbance (Muurling et al, 2020), but additional studies are needed to fully understand the connections between tauopathies and gait dysfunction (Wennberg et al, 2017). Like humans, slow gait in vervets was associated with lower CSF Aβ 1–42 and higher brain concentrations of Aβ 1–42 (Latimer et al, 2019).…”

Section: Aging‐related Physical Declinementioning

confidence: 99%

Aging‐related Alzheimer's disease‐like neuropathology and functional decline in captive vervet monkeys (Chlorocebus aethiops sabaeus)

Frye

Craft

Latimer

et al. 2021

American J Primatol

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Age-related neurodegeneration characteristic of late-onset Alzheimer's disease (LOAD) begins in middle age, well before symptoms. Translational models to identify modifiable risk factors are needed to understand etiology and identify therapeutic targets. Here, we outline the evidence supporting the vervet monkey (Chlorocebus aethiops sabaeus) as a model of aging-related AD-like neuropathology and associated phenotypes including cognitive function, physical function, glucose handling, intestinal physiology, and CSF, blood, and neuroimaging biomarkers. This review provides the most comprehensive multisystem description of aging in vervets to date. This review synthesizes a large body of evidence that suggests that aging vervets exhibit a coordinated suite of traits consistent with early AD and provide a powerful, naturally occurring model for LOAD. Notably, relationships are identified between AD-like neuropathology and modifiable risk factors. Gaps in knowledge and key limitations are provided to shape future studies to illuminate mechanisms underlying divergent neurocognitive aging trajectories and to develop interventions that increase resilience to aging-associated chronic disease, particularly, LOAD.

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“…Quantitative tests have revealed gait dysfunction in subjects with amnestic and non-amnestic mild cognitive impairment (MCI) subtypes compared with healthy controls ( Verghese et al, 2008 ). Furthermore, cognitive impairment has been found to affect spatiotemporal parameters of gait under dual-task performance ( Montero-Odasso et al, 2014 ; Muurling et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Gait Kinematic and Kinetic Characteristics of Older Adults With Mild Cognitive Impairment and Subjective Cognitive Decline: A Cross-Sectional Study

Zhong

Ali

Gao

et al. 2021

Front. Aging Neurosci.

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BackgroundOlder adults with mild cognitive impairment (MCI) have slower gait speed and poor gait performance under dual-task conditions. However, gait kinematic and kinetic characteristics in older adults with MCI or subjective cognitive decline (SCD) remain unknown. This study was designed to explore the difference in gait kinematics and kinetics during level walking among older people with MCI, SCD, and normal cognition (NC).MethodsThis cross-sectional study recruited 181 participants from July to December 2019; only 82 met the inclusion criteria and consented to participate and only 79 completed gait analysis. Kinematic and kinetic data were obtained using three-dimensional motion capture system during level walking, and joint movements of the lower limbs in the sagittal plane were analyzed by Visual 3D software. Differences in gait kinematics and kinetics among the groups were analyzed using multivariate analysis of covariance (MANCOVA) with Bonferroni post-hoc analysis. After adjusting for multiple comparisons, the significance level was p < 0.002 for MANCOVA and p < 0.0008 for post-hoc analysis.ResultsTwenty-two participants were MCI [mean ± standard deviation (SD) age, 71.23 ± 6.65 years], 33 were SCD (age, 72.73 ± 5.25 years), and 24 were NC (age, 71.96 ± 5.30 years). MANCOVA adjusted for age, gender, body mass index (BMI), gait speed, years of education, diabetes mellitus, and Geriatric Depression Scale (GDS) revealed a significant multivariate effect of group in knee peak extension angle (F = 8.77, p < 0.0001) and knee heel strike angle (F = 8.07, p = 0.001) on the right side. Post-hoc comparisons with Bonferroni correction showed a significant increase of 5.91° in knee peak extension angle (p < 0.0001) and a noticeable decrease of 6.21°in knee heel strike angle (p = 0.001) in MCI compared with NC on the right side. However, no significant intergroup difference was found in gait kinetics, including dorsiflexion, plantar flexion, knee flexion, knee extension, hip flexion, and hip extension(p > 0.002).ConclusionAn increase of right knee peak extension angle and a decrease of right knee heel strike angle during level walking were found among older adults with MCI compared to those with NC.

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Gait Disturbances are Associated with Increased Cognitive Impairment and Cerebrospinal Fluid Tau Levels in a Memory Clinic Cohort

Cited by 16 publications

References 37 publications

Dual-Task Gait as a Predictive Tool for Cognitive Impairment in Older Adults: A Systematic Review

Dual-Task Gait as a Predictive Tool for Cognitive Impairment in Older Adults: A Systematic Review

Aging‐related Alzheimer's disease‐like neuropathology and functional decline in captive vervet monkeys (Chlorocebus aethiops sabaeus)

Gait Kinematic and Kinetic Characteristics of Older Adults With Mild Cognitive Impairment and Subjective Cognitive Decline: A Cross-Sectional Study

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